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LRRC29 leucine rich repeat containing 29 [ Homo sapiens (human) ]

Gene ID: 26231, updated on 23-Nov-2021

Summary

Official Symbol
LRRC29provided by HGNC
Official Full Name
leucine rich repeat containing 29provided by HGNC
Primary source
HGNC:HGNC:13605
See related
Ensembl:ENSG00000125122
Gene type
pseudo
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
FBL9; FBXL9
Summary
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains 9 tandem leucine-rich repeats. Two transcript variants encoding the same protein have been found for this gene. Other variants may occur, but their full-length natures have not been characterized. [provided by RefSeq, Jul 2008]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See LRRC29 in Genome Data Viewer
Location:
16q22.1
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (67207139..67227025, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (67241042..67260928, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene E2F transcription factor 4 Neighboring gene engulfment and cell motility 3 Neighboring gene microRNA 328 Neighboring gene transmembrane protein 208 Neighboring gene formin homology 2 domain containing 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Other Names

  • F-box and leucine-rich repeat protein 9
  • F-box protein FBL9
  • F-box/LRR-repeat protein 9
  • leucine-rich repeat-containing protein 29

Clone Names

  • FLJ57407

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

RNA

  1. NR_172488.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC040160
  2. NR_172489.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC040160
  3. NR_172490.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC040160

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    67207139..67227025 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001004055.2: Suppressed sequence

    Description
    NM_001004055.2: This RefSeq was removed because currently there is support for the transcript but not for the protein.
  2. NM_001365158.1: Suppressed sequence

    Description
    NM_001365158.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
  3. NM_001365159.1: Suppressed sequence

    Description
    NM_001365159.1: This RefSeq was removed because currently there is support for the transcript but not for the protein.
  4. NM_012163.3: Suppressed sequence

    Description
    NM_012163.3: This RefSeq was removed because currently there is support for the transcript but not for the protein.
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