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OR2F1 olfactory receptor family 2 subfamily F member 1 [ Homo sapiens (human) ]

Gene ID: 26211, updated on 11-Jun-2021

Summary

Official Symbol
OR2F1provided by HGNC
Official Full Name
olfactory receptor family 2 subfamily F member 1provided by HGNC
Primary source
HGNC:HGNC:8246
See related
Ensembl:ENSG00000213215 MIM:608497
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OLF3; 7M1-2; OR2F3; OR2F4; OR2F5; OR2F3P; OR14-60; OR7-139; OR7-140
Summary
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]
Expression
Low expression observed in reference dataset See more
Orthologs
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Genomic context

See OR2F1 in Genome Data Viewer
Location:
7q35
Exon count:
5
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (143907152..143964360)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (143651937..143661453)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC112267988 Neighboring gene TRPM8 channel associated factor 1 Neighboring gene uncharacterized LOC105375549 Neighboring gene olfactory receptor family 2 subfamily F member 2 Neighboring gene CAPZA1 pseudogene 5 Neighboring gene olfactory receptor family 2 subfamily Q member 1 pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
 
enables olfactory receptor activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in detection of chemical stimulus involved in sensory perception of smell IEA
Inferred from Electronic Annotation
more info
 
involved_in signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
olfactory receptor 2F1
Names
olfactory receptor 2F3
olfactory receptor 2F4
olfactory receptor 2F5
olfactory receptor OR7-7
olfactory receptor, family 2, subfamily F, member 3
olfactory receptor, family 2, subfamily F, member 4
olfactory receptor, family 2, subfamily F, member 5
olfactory receptor-like protein OLF3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012369.3NP_036501.2  olfactory receptor 2F1

    See identical proteins and their annotated locations for NP_036501.2

    Status: VALIDATED

    Source sequence(s)
    AC004853
    UniProtKB/Swiss-Prot
    Q13607
    UniProtKB/TrEMBL
    A0A126GV98
    Related
    ENSP00000493004.1, ENST00000641412.1
    Conserved Domains (2) summary
    pfam00001
    Location:41290
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:31305
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    143907152..143964360
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011516020.2XP_011514322.1  olfactory receptor 2F1 isoform X1

    See identical proteins and their annotated locations for XP_011514322.1

    UniProtKB/Swiss-Prot
    Q13607
    UniProtKB/TrEMBL
    A0A126GV98
    Related
    ENSP00000485483.1, ENST00000624504.1
    Conserved Domains (2) summary
    pfam00001
    Location:41290
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:31305
    7tm_4; Olfactory receptor
  2. XM_011516019.3XP_011514321.1  olfactory receptor 2F1 isoform X1

    See identical proteins and their annotated locations for XP_011514321.1

    UniProtKB/Swiss-Prot
    Q13607
    UniProtKB/TrEMBL
    A0A126GV98
    Conserved Domains (2) summary
    pfam00001
    Location:41290
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    cl21561
    Location:31305
    7tm_4; Olfactory receptor

Reference GRCh38.p13 PATCHES

Genomic

  1. NW_018654714.1 Reference GRCh38.p13 PATCHES

    Range
    499074..508590
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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