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OR2F1 olfactory receptor family 2 subfamily F member 1 [ Homo sapiens (human) ]

Gene ID: 26211, updated on 17-Jun-2024


Official Symbol
OR2F1provided by HGNC
Official Full Name
olfactory receptor family 2 subfamily F member 1provided by HGNC
Primary source
See related
Ensembl:ENSG00000213215 MIM:608497; AllianceGenome:HGNC:8246
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
OLF3; 7M1-2; OR2F3; OR2F4; OR2F5; OR2F3P; OR14-60; OR7-139; OR7-140
Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. This olfactory receptor gene is a segregating pseudogene, where some individuals have an allele that encodes a functional olfactory receptor, while other individuals have an allele encoding a protein that is predicted to be non-functional. [provided by RefSeq, Jun 2015]
Annotation information
Note: Genetic polymorphisms result in both protein coding and non-coding alleles of this gene.
Low expression observed in reference dataset See more
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Genomic context

See OR2F1 in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (143954844..143964360)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (145235198..145244714)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (143651937..143661453)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene TRPM8 channel associated factor 1 Neighboring gene uncharacterized LOC105375549 Neighboring gene H3K27ac hESC enhancer GRCh37_chr7:143598237-143598774 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18728 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:143602842-143603342 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:143603883-143604439 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr7:143632675-143633174 Neighboring gene olfactory receptor family 2 subfamily F member 2 Neighboring gene CAPZA1 pseudogene 5 Neighboring gene olfactory receptor family 2 subfamily Q member 1 pseudogene

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Pathways from PubChem

General gene information


Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables G protein-coupled receptor activity IEA
Inferred from Electronic Annotation
more info
enables olfactory receptor activity IBA
Inferred from Biological aspect of Ancestor
more info
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
involved_in detection of chemical stimulus involved in sensory perception of smell IBA
Inferred from Biological aspect of Ancestor
more info
involved_in signal transduction NAS
Non-traceable Author Statement
more info
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
located_in plasma membrane TAS
Traceable Author Statement
more info

General protein information

Preferred Names
olfactory receptor 2F1
olfactory receptor 2F3
olfactory receptor 2F4
olfactory receptor 2F5
olfactory receptor OR7-7
olfactory receptor, family 2, subfamily F, member 3
olfactory receptor, family 2, subfamily F, member 4
olfactory receptor, family 2, subfamily F, member 5
olfactory receptor-like protein OLF3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_012369.3NP_036501.2  olfactory receptor 2F1

    See identical proteins and their annotated locations for NP_036501.2

    Status: VALIDATED

    Source sequence(s)
    A4D2G1, Q13607, Q6IFP7, Q96R49, Q9UDX1
    A0A126GV98, A0A126GWI5
    ENSP00000493004.1, ENST00000641412.1
    Conserved Domains (2) summary
    7tm_1; 7 transmembrane receptor (rhodopsin family)
    7tm_4; Olfactory receptor

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly


  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    GenBank, FASTA, Sequence Viewer (Graphics)

Reference GRCh38.p14 PATCHES


  1. NW_018654714.1 Reference GRCh38.p14 PATCHES

    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0


  1. NC_060931.1 Alternate T2T-CHM13v2.0

    GenBank, FASTA, Sequence Viewer (Graphics)