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GAS6 growth arrest specific 6 [ Homo sapiens (human) ]

Gene ID: 2621, updated on 3-Jun-2018
Official Symbol
GAS6provided by HGNC
Official Full Name
growth arrest specific 6provided by HGNC
Primary source
HGNC:HGNC:4168
See related
Ensembl:ENSG00000183087 MIM:600441; Vega:OTTHUMG00000017395
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AXSF; AXLLG
Summary
This gene encodes a gamma-carboxyglutamic acid (Gla)-containing protein thought to be involved in the stimulation of cell proliferation. This gene is frequently overexpressed in many cancers and has been implicated as an adverse prognostic marker. Elevated protein levels are additionally associated with a variety of disease states, including venous thromboembolic disease, systemic lupus erythematosus, chronic renal failure, and preeclampsia. [provided by RefSeq, Aug 2014]
Expression
Ubiquitous expression in lung (RPKM 64.9), endometrium (RPKM 57.7) and 24 other tissues See more
Orthologs
See GAS6 in Genome Data Viewer
Location:
13q34
Exon count:
15
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 13 NC_000013.11 (113820549..113864103, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (114523522..114567046, complement)

Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene basic salivary proline-rich protein 4-like Neighboring gene long intergenic non-protein coding RNA 552 Neighboring gene transmembrane protein 255B Neighboring gene uncharacterized LOC105370380 Neighboring gene GAS6 antisense RNA 1 Neighboring gene GAS6 divergent transcript Neighboring gene long intergenic non-protein coding RNA 454

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • FLJ34709, DKFZp666G247

Gene Ontology Provided by GOA

Function Evidence Code Pubs
calcium ion binding IEA
Inferred from Electronic Annotation
more info
 
cysteine-type endopeptidase inhibitor activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
molecular adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
phosphatidylserine binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein tyrosine kinase activator activity IDA
Inferred from Direct Assay
more info
PubMed 
receptor ligand activity IDA
Inferred from Direct Assay
more info
PubMed 
receptor tyrosine kinase binding IPI
Inferred from Physical Interaction
more info
PubMed 
signaling receptor binding IDA
Inferred from Direct Assay
more info
PubMed 
signaling receptor binding IPI
Inferred from Physical Interaction
more info
PubMed 
voltage-gated calcium channel activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
B cell chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
ER to Golgi vesicle-mediated transport TAS
Traceable Author Statement
more info
 
activation of protein kinase B activity ISS
Inferred from Sequence or Structural Similarity
more info
 
animal organ regeneration IEA
Inferred from Electronic Annotation
more info
 
apoptotic cell clearance IDA
Inferred from Direct Assay
more info
PubMed 
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
calcium ion transmembrane transport IDA
Inferred from Direct Assay
more info
PubMed 
cell adhesion TAS
Traceable Author Statement
more info
PubMed 
cell cycle arrest TAS
Traceable Author Statement
more info
PubMed 
cell migration TAS
Traceable Author Statement
more info
PubMed 
cell proliferation TAS
Traceable Author Statement
more info
PubMed 
cell-substrate adhesion IEA
Inferred from Electronic Annotation
more info
 
cellular protein metabolic process TAS
Traceable Author Statement
more info
 
cellular response to drug IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to glucose stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
cellular response to growth factor stimulus IEA
Inferred from Electronic Annotation
more info
 
cellular response to interferon-alpha IDA
Inferred from Direct Assay
more info
PubMed 
cellular response to starvation IEA
Inferred from Electronic Annotation
more info
 
cellular response to vitamin K IDA
Inferred from Direct Assay
more info
PubMed 
dendritic cell differentiation IEP
Inferred from Expression Pattern
more info
PubMed 
enzyme linked receptor protein signaling pathway IEA
Inferred from Electronic Annotation
more info
 
extracellular matrix assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
fusion of virus membrane with host plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
hematopoietic stem cell migration to bone marrow IDA
Inferred from Direct Assay
more info
PubMed 
leukocyte migration TAS
Traceable Author Statement
more info
 
macrophage cytokine production IEA
Inferred from Electronic Annotation
more info
 
negative regulation of DNA-binding transcription factor activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of biomineral tissue development IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of cysteine-type endopeptidase activity involved in apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of dendritic cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of endothelial cell apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of fibroblast apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of interferon-gamma production IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of interleukin-1 secretion IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of interleukin-6 production IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of interleukin-6 secretion IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of oligodendrocyte apoptotic process IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of protein import into nucleus, translocation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of renal albumin absorption ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of tumor necrosis factor production IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of tumor necrosis factor-mediated signaling pathway IDA
Inferred from Direct Assay
more info
PubMed 
neuron migration IEA
Inferred from Electronic Annotation
more info
 
peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
phagocytosis IDA
Inferred from Direct Assay
more info
PubMed 
platelet activation TAS
Traceable Author Statement
more info
PubMed 
platelet aggregation TAS
Traceable Author Statement
more info
PubMed 
platelet degranulation TAS
Traceable Author Statement
more info
 
positive regulation of ERK1 and ERK2 cascade IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of TOR signaling ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cytokine-mediated signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of dendritic cell chemotaxis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of fibroblast proliferation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene expression IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of glomerular filtration ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of natural killer cell differentiation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of peptidyl-serine phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of phagocytosis IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein export from nucleus IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein kinase B signaling IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of protein phosphorylation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of protein tyrosine kinase activity IDA
Inferred from Direct Assay
more info
PubMed 
post-translational protein modification TAS
Traceable Author Statement
more info
 
protein kinase B signaling IDA
Inferred from Direct Assay
more info
PubMed 
protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
protein phosphorylation IDA
Inferred from Direct Assay
more info
PubMed 
receptor-mediated virion attachment to host cell IDA
Inferred from Direct Assay
more info
PubMed 
regulation of growth IEA
Inferred from Electronic Annotation
more info
 
regulation of signaling receptor activity IEA
Inferred from Electronic Annotation
more info
 
signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
signal transduction TAS
Traceable Author Statement
more info
PubMed 
viral entry into host cell IDA
Inferred from Direct Assay
more info
PubMed 
viral genome replication IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Golgi lumen TAS
Traceable Author Statement
more info
 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
endoplasmic reticulum lumen TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
extracellular region TAS
Traceable Author Statement
more info
 
extracellular space IDA
Inferred from Direct Assay
more info
PubMed 
platelet alpha granule lumen TAS
Traceable Author Statement
more info
 
Preferred Names
growth arrest-specific protein 6
Names
AXL receptor tyrosine kinase ligand
AXL stimulatory factor

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_029703.1 RefSeqGene

    Range
    4971..48525
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_000820.3NP_000811.1  growth arrest-specific protein 6 precursor

    See identical proteins and their annotated locations for NP_000811.1

    Status: REVIEWED

    Source sequence(s)
    AA045119, BC038984, BX380508, HY038614
    Consensus CDS
    CCDS45072.1
    UniProtKB/Swiss-Prot
    Q14393
    Related
    ENSP00000331831.6, OTTHUMP00000018777, ENST00000327773.6, OTTHUMT00000045946
    Conserved Domains (7) summary
    smart00069
    Location:4092
    GLA; Domain containing Gla (gamma-carboxyglutamate) residues
    smart00179
    Location:197227
    EGF_CA; Calcium-binding EGF-like domain
    cd00054
    Location:118153
    EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
    cd00110
    Location:298450
    LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...
    pfam02210
    Location:513651
    Laminin_G_2; Laminin G domain
    pfam12662
    Location:218241
    cEGF; Complement Clr-like EGF-like
    pfam14670
    Location:160195
    FXa_inhibition; Coagulation Factor Xa inhibitory site

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000013.11 Reference GRCh38.p12 Primary Assembly

    Range
    113820549..113864103 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001143945.1: Suppressed sequence

    Description
    NM_001143945.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
  2. NM_001143946.1: Suppressed sequence

    Description
    NM_001143946.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
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