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GAS1 growth arrest specific 1 [ Homo sapiens (human) ]

Gene ID: 2619, updated on 11-Jun-2021

Summary

Official Symbol
GAS1provided by HGNC
Official Full Name
growth arrest specific 1provided by HGNC
Primary source
HGNC:HGNC:4165
See related
Ensembl:ENSG00000180447 MIM:139185
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Growth arrest-specific 1 plays a role in growth suppression. GAS1 blocks entry to S phase and prevents cycling of normal and transformed cells. Gas1 is a putative tumor suppressor gene. [provided by RefSeq, Jul 2008]
Orthologs
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Genomic context

See GAS1 in Genome Data Viewer
Location:
9q21.33
Exon count:
1
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (86944362..86947506, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (89559277..89562421, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105376123 Neighboring gene long intergenic non-protein coding RNA 2834 Neighboring gene GAS1 adjacent regulatory RNA Neighboring gene long intergenic non-protein coding RNA 2893 Neighboring gene cell division cycle 20 pseudogene 1

Genomic regions, transcripts, and products

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide detection of allele specific copy number variation associated with insulin resistance in African Americans from the HyperGEN study.
GeneReviews: Not available

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Envelope surface glycoprotein gp120 env The mRNA expression levels for alpha-tubulin, TRADD, IFN-gamma R2, GAS1, MADD, NF-kappaB, I-kappa B, 14-3-3 protein, APaf1, PARP, IGF-1 receptor, RB1, Rb2/p130, ARC, and caspase 6 are upregulated in human neuronal cells after treatment with HIV-1 gp120 PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
 
involved_in cell fate commitment ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cellular response to vascular endothelial growth factor stimulus IEP
Inferred from Expression Pattern
more info
PubMed 
involved_in developmental growth ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in negative regulation of mitotic cell cycle IDA
Inferred from Direct Assay
more info
PubMed 
acts_upstream_of_or_within negative regulation of mitotic cell cycle IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of protein processing IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of ER to Golgi vesicle-mediated transport IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of apoptotic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of smoothened signaling pathway ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in anchored component of plasma membrane ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in integral component of membrane NAS
Non-traceable Author Statement
more info
PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
growth arrest-specific protein 1
Names
GAS-1
Growth arrest-specific gene-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_032760.1 RefSeqGene

    Range
    4684..7828
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_002048.3NP_002039.2  growth arrest-specific protein 1 precursor

    See identical proteins and their annotated locations for NP_002039.2

    Status: REVIEWED

    Source sequence(s)
    AL158149, BC132682, BM661942, L13698
    Consensus CDS
    CCDS6674.1
    UniProtKB/Swiss-Prot
    P54826
    Related
    ENSP00000298743.7, ENST00000298743.9
    Conserved Domains (1) summary
    smart00907
    Location:48143
    GDNF; GDNF/GAS1 domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    86944362..86947506 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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