STEAP2 STEAP2 metalloreductase [Homo sapiens (human)] - Gene

Summary

Official Symbol: STEAP2provided by HGNC
Official Full Name: STEAP2 metalloreductaseprovided by HGNC
Primary source: HGNC:HGNC:17885
See related: Ensembl:ENSG00000157214 MIM:605094; AllianceGenome:HGNC:17885
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: STMP; IPCA1; PUMPCn; STAMP1; PCANAP1
Summary: This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Expression: Biased expression in prostate (RPKM 47.3), gall bladder (RPKM 4.2) and 6 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 7q21.13

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
110	current	GRCh38.p14 (GCF_000001405.40)	7	NC_000007.14 (90211740..90243408)
110	current	T2T-CHM13v2.0 (GCF_009914755.1)	7	NC_060931.1 (91460045..91485989)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	7	NC_000007.13 (89841054..89866997)

Chromosome 7 - NC_000007.14 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

STEAP2 promotes osteosarcoma progression by inducing epithelial-mesenchymal transition via the PI3K/AKT/mTOR signaling pathway and is regulated by EFEMP2.
Title: STEAP2 promotes osteosarcoma progression by inducing epithelial-mesenchymal transition via the PI3K/AKT/mTOR signaling pathway and is regulated by EFEMP2.
METTL3-mediated m6A modification of STEAP2 mRNA inhibits papillary thyroid cancer progress by blocking the Hedgehog signaling pathway and epithelial-to-mesenchymal transition.
Title: METTL3-mediated m6A modification of STEAP2 mRNA inhibits papillary thyroid cancer progress by blocking the Hedgehog signaling pathway and epithelial-to-mesenchymal transition.
Predictive potential of STEAP family for survival, immune microenvironment and therapy response in glioma.
Title: Predictive potential of STEAP family for survival, immune microenvironment and therapy response in glioma.
STEAP2 is down-regulated in breast cancer tissue and suppresses PI3K/AKT signaling and breast cancer cell invasion in vitro and in vivo.
Title: STEAP2 is down-regulated in breast cancer tissue and suppresses PI3K/AKT signaling and breast cancer cell invasion in vitro and in vivo.
The Tumor Suppressive Roles and Prognostic Values of STEAP Family Members in Breast Cancer.
Title: The Tumor Suppressive Roles and Prognostic Values of STEAP Family Members in Breast Cancer.
STEAP2 drives aggressive prostate cancer traits by promoting proliferation, migration and invasion and significantly influencing the transcriptional profile of ten genes underlying the metastatic cascade.
Title: STEAP2 Knockdown Reduces the Invasive Potential of Prostate Cancer Cells.
The conformational modulation of STEAP2 by the local membrane cholesterol content can therefore serve as a potential mechanism to modulate STEAP2 function in a compartment-restricted manner
Title: Membrane cholesterol modulates STEAP2 conformation during dynamic intracellular trafficking processes leading to broad subcellular distribution.
Over-expression of STEAP2 is associated with prostate cancer progression.
Title: A role for STEAP2 in prostate cancer progression.
Data suggest that STAMP1 is required for prostate cancer growth.
Title: STAMP1 is both a proliferative and an antiapoptotic factor in prostate cancer.
Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ECD11319 (e-PCR)
- UniSTS:292355

D11S2921 (e-PCR)
- UniSTS:152074

REN106317 (e-PCR)
- UniSTS:431114

REN106325 (e-PCR)
- UniSTS:431122

REN106326 (e-PCR)
- UniSTS:431123

ECD03353 (e-PCR)
- UniSTS:284438

REN106078 (e-PCR)
- UniSTS:430875

ECD13148 (e-PCR)
- UniSTS:294179

ECD15981 (e-PCR)
- UniSTS:296996

REN106348 (e-PCR)
- UniSTS:431145

REN106349 (e-PCR)
- UniSTS:431146

REN106350 (e-PCR)
- UniSTS:431147

REN106351 (e-PCR)
- UniSTS:431148

REN106352 (e-PCR)
- UniSTS:431149

REN106353 (e-PCR)
- UniSTS:431150

REN106354 (e-PCR)
- UniSTS:431151

REN106355 (e-PCR)
- UniSTS:431152

REN106356 (e-PCR)
- UniSTS:431153

D8S2278 (e-PCR)
- UniSTS:473906

REN106357 (e-PCR)
- UniSTS:431154

D8S2279 (e-PCR)
- UniSTS:473907

REN106358 (e-PCR)
- UniSTS:431155

REN106359 (e-PCR)
- UniSTS:431156

REN106360 (e-PCR)
- UniSTS:431157

REN106361 (e-PCR)
- UniSTS:431158

REN106362 (e-PCR)
- UniSTS:431159

REN106363 (e-PCR)
- UniSTS:431160

REN106364 (e-PCR)
- UniSTS:431161

REN106365 (e-PCR)
- UniSTS:431162

REN106366 (e-PCR)
- UniSTS:431163

REN106367 (e-PCR)
- UniSTS:431164

REN106368 (e-PCR)
- UniSTS:431165

REN106369 (e-PCR)
- UniSTS:431166

stSG614476 (e-PCR)
- UniSTS:450367

ECD23983 (e-PCR)
- UniSTS:304967

stSG614487 (e-PCR)
- UniSTS:450377

stSG614488 (e-PCR)
- UniSTS:450378

stSG614489 (e-PCR)
- UniSTS:450379

stSG614490 (e-PCR)
- UniSTS:450380

ECD02372 (e-PCR)
- UniSTS:283471

ECD11140 (e-PCR)
- UniSTS:292176

L18426 (e-PCR)
- UniSTS:34648

ECD17831 (e-PCR)
- UniSTS:298843

SHGC-52882 (e-PCR)
- UniSTS:60763

ECD02659 (e-PCR)
- UniSTS:283753

ECD23509 (e-PCR)
- UniSTS:304493

D1S1423 (e-PCR)
- UniSTS:149619

ECD00623 (e-PCR)
- UniSTS:281732

ECD17106 (e-PCR)
- UniSTS:298119

ECD24311 (e-PCR)
- UniSTS:305295

ECD10433 (e-PCR)
- UniSTS:291472

ECD06575 (e-PCR)
- UniSTS:287635

NoName (e-PCR)
- UniSTS:482462

RH79249 (e-PCR)
- UniSTS:26271

ECD09426 (e-PCR)
- UniSTS:290469

ECD04274 (e-PCR)
- UniSTS:285352

ECD16895 (e-PCR)
- UniSTS:297909

ECD16896 (e-PCR)
- UniSTS:297910

ECD17677 (e-PCR)
- UniSTS:298689

ECD23598 (e-PCR)
- UniSTS:304582

ECD02493 (e-PCR)
- UniSTS:283591

ECD02494 (e-PCR)
- UniSTS:283592

ECD01471 (e-PCR)
- UniSTS:282574

REN106272 (e-PCR)
- UniSTS:431069

REN106273 (e-PCR)
- UniSTS:431070

ECD03815 (e-PCR)
- UniSTS:284895

REN106274 (e-PCR)
- UniSTS:431071

REN106275 (e-PCR)
- UniSTS:431072

REN106276 (e-PCR)
- UniSTS:431073

ECD06424 (e-PCR)
- UniSTS:287484

Homology

Homologs of the STEAP2 gene: The STEAP2 gene is conserved in chimpanzee, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Orthologs from Annotation Pipeline: 436 organisms have orthologs with human gene STEAP2
Orthologs

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables cupric reductase activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables ferric-chelate reductase (NADPH) activity	IBA Inferred from Biological aspect of Ancestor more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in Golgi to plasma membrane transport	IDA Inferred from Direct Assay more info	PubMed
involved_in copper ion import	IBA Inferred from Biological aspect of Ancestor more info	PubMed
involved_in copper ion import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in endocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in iron ion import across plasma membrane	IEA Inferred from Electronic Annotation more info
involved_in regulated exocytosis	IDA Inferred from Direct Assay more info	PubMed
involved_in response to hormone	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi membrane	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in endosome	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in endosome membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info	PubMed
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network transport vesicle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: metalloreductase STEAP2

Names: STEAP family member 2, metalloreductase; SixTransMembrane Protein of Prostate 1; prostate cancer-associated protein 1; protein up-regulated in metastatic prostate cancer; protein upregulated in metastatic prostate cancer; six transmembrane epithelial antigen of the prostate 2; six-transmembrane epithelial antigen of prostate 2

NP_001035755.1

EC 1.16.1.-

NP_001035756.1

EC 1.16.1.-

NP_001231873.1

EC 1.16.1.-

NP_001231874.1

EC 1.16.1.-

NP_001231875.1

EC 1.16.1.-

NP_694544.2

EC 1.16.1.-

XP_006715984.1

EC 1.16.1.-

XP_016867442.1

EC 1.16.1.-

XP_016867443.1

EC 1.16.1.-

XP_016867444.1

EC 1.16.1.-

XP_016867445.1

EC 1.16.1.-

XP_016867446.1

EC 1.16.1.-

XP_016867447.1

EC 1.16.1.-

XP_047276128.1

EC 1.16.1.-

XP_047276129.1

EC 1.16.1.-

XP_047276130.1

EC 1.16.1.-

XP_047276131.1

EC 1.16.1.-

XP_047276132.1

EC 1.16.1.-

XP_047276133.1

EC 1.16.1.-

XP_047276134.1

EC 1.16.1.-

XP_047276135.1

EC 1.16.1.-

XP_047276136.1

EC 1.16.1.-

XP_047276137.1

EC 1.16.1.-

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001040665.2 → NP_001035755.1 metalloreductase STEAP2 isoform a

See identical proteins and their annotated locations for NP_001035755.1

Status: REVIEWED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 4 encode the same isoform.

Source sequence(s)

AC002064, AK092666, AY008443, AY008444

Consensus CDS

CCDS5615.1

UniProtKB/Swiss-Prot

Q8IUE7, Q8NFT2

UniProtKB/TrEMBL

B3KS24, Q6YPB2

Related

ENSP00000378120.2, ENST00000394622.6

Conserved Domains (3) summary

COG2085
Location:32 → 217

COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]

pfam01794
Location:262 → 405

Ferric_reduct; Ferric reductase like transmembrane component

pfam03807
Location:34 → 119

F420_oxidored; NADP oxidoreductase coenzyme F420-dependent
NM_001040666.2 → NP_001035756.1 metalloreductase STEAP2 isoform b

See identical proteins and their annotated locations for NP_001035756.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, 3' UTR, and 3' coding region compared to variant 1, resulting in a protein (isoform b) that is shorter and has a unique C-terminus, compared to isoform a.

Source sequence(s)

AC002064, AF526382, AK092666, AY008443

Consensus CDS

CCDS43612.1

UniProtKB/Swiss-Prot

Q8NFT2

UniProtKB/TrEMBL

B3KS24, Q6YPB2

Related

ENSP00000378125.2, ENST00000394629.2

Conserved Domains (3) summary

COG2085
Location:32 → 217

COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]

pfam01794
Location:262 → 405

Ferric_reduct; Ferric reductase like transmembrane component

pfam03807
Location:34 → 119

F420_oxidored; NADP oxidoreductase coenzyme F420-dependent
NM_001244944.2 → NP_001231873.1 metalloreductase STEAP2 isoform a

See identical proteins and their annotated locations for NP_001231873.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 4 encode the same isoform.

Source sequence(s)

AC002064

Consensus CDS

CCDS5615.1

UniProtKB/Swiss-Prot

Q8IUE7, Q8NFT2

Related

ENSP00000378119.2, ENST00000394621.7

Conserved Domains (3) summary

COG2085
Location:32 → 217

COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]

pfam01794
Location:262 → 405

Ferric_reduct; Ferric reductase like transmembrane component

pfam03807
Location:34 → 119

F420_oxidored; NADP oxidoreductase coenzyme F420-dependent
NM_001244945.2 → NP_001231874.1 metalloreductase STEAP2 isoform b

See identical proteins and their annotated locations for NP_001231874.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) differs in the 3' UTR, and 3' coding region compared to variant 1, resulting in a protein (isoform b) that is shorter and has a unique C-terminus, compared to isoform a.

Source sequence(s)

AC002064

Consensus CDS

CCDS43612.1

UniProtKB/TrEMBL

Q6YPB2

Related

ENSP00000378123.1, ENST00000394626.5

Conserved Domains (3) summary

COG2085
Location:32 → 217

COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]

pfam01794
Location:262 → 405

Ferric_reduct; Ferric reductase like transmembrane component

pfam03807
Location:34 → 119

F420_oxidored; NADP oxidoreductase coenzyme F420-dependent
NM_001244946.2 → NP_001231875.1 metalloreductase STEAP2 isoform c

See identical proteins and their annotated locations for NP_001231875.1

Status: REVIEWED

Description

Transcript Variant: This variant (6) differs in the 5' UTR, 3' UTR, and 3' coding region compared to variant 1, resulting in a protein (isoform c) that is shorter and has a unique C-terminus, compared to isoform a.

Source sequence(s)

AC002064

Consensus CDS

CCDS59064.1

UniProtKB/Swiss-Prot

Q8NFT2

Related

ENSP00000378128.1, ENST00000394632.5

Conserved Domains (3) summary

COG2085
Location:32 → 217

COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]

pfam01794
Location:262 → 401

Ferric_reduct; Ferric reductase like transmembrane component

pfam03807
Location:34 → 119

F420_oxidored; NADP oxidoreductase coenzyme F420-dependent
NM_152999.4 → NP_694544.2 metalloreductase STEAP2 isoform a

See identical proteins and their annotated locations for NP_694544.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1, 2 and 4 encode the same isoform.

Source sequence(s)

AC002064, AF455138, AK092666, AY008443, DR005432

Consensus CDS

CCDS5615.1

UniProtKB/Swiss-Prot

Q8IUE7, Q8NFT2

UniProtKB/TrEMBL

B3KS24, Q6YPB2

Related

ENSP00000287908.3, ENST00000287908.7

Conserved Domains (3) summary

COG2085
Location:32 → 217

COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]

pfam01794
Location:262 → 405

Ferric_reduct; Ferric reductase like transmembrane component

pfam03807
Location:34 → 119

F420_oxidored; NADP oxidoreductase coenzyme F420-dependent

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000007.14 Reference GRCh38.p14 Primary Assembly

Range

90211740..90243408

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_047420172.1 → XP_047276128.1 metalloreductase STEAP2 isoform X1

UniProtKB/Swiss-Prot

Q8IUE7
XM_047420175.1 → XP_047276131.1 metalloreductase STEAP2 isoform X1

UniProtKB/Swiss-Prot

Q8IUE7
XM_047420180.1 → XP_047276136.1 metalloreductase STEAP2 isoform X3

UniProtKB/TrEMBL

Q6YPB2
XM_006715921.5 → XP_006715984.1 metalloreductase STEAP2 isoform X1

See identical proteins and their annotated locations for XP_006715984.1

UniProtKB/Swiss-Prot

Q8IUE7, Q8NFT2

Conserved Domains (3) summary

COG2085
Location:32 → 217

COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]

pfam01794
Location:262 → 405

Ferric_reduct; Ferric reductase like transmembrane component

pfam03807
Location:34 → 119

F420_oxidored; NADP oxidoreductase coenzyme F420-dependent
XM_017011956.3 → XP_016867445.1 metalloreductase STEAP2 isoform X3

UniProtKB/TrEMBL

Q6YPB2

Conserved Domains (3) summary

COG2085
Location:32 → 217

COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]

pfam01794
Location:262 → 405

Ferric_reduct; Ferric reductase like transmembrane component

pfam03807
Location:34 → 119

F420_oxidored; NADP oxidoreductase coenzyme F420-dependent
XM_017011957.2 → XP_016867446.1 metalloreductase STEAP2 isoform X3

UniProtKB/TrEMBL

Q6YPB2

Conserved Domains (3) summary

COG2085
Location:32 → 217

COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]

pfam01794
Location:262 → 405

Ferric_reduct; Ferric reductase like transmembrane component

pfam03807
Location:34 → 119

F420_oxidored; NADP oxidoreductase coenzyme F420-dependent
XM_047420174.1 → XP_047276130.1 metalloreductase STEAP2 isoform X1

UniProtKB/Swiss-Prot

Q8IUE7
XM_047420173.1 → XP_047276129.1 metalloreductase STEAP2 isoform X1

UniProtKB/Swiss-Prot

Q8IUE7
XM_017011953.3 → XP_016867442.1 metalloreductase STEAP2 isoform X1

UniProtKB/Swiss-Prot

Q8IUE7, Q8NFT2

Conserved Domains (3) summary

COG2085
Location:32 → 217

COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]

pfam01794
Location:262 → 405

Ferric_reduct; Ferric reductase like transmembrane component

pfam03807
Location:34 → 119

F420_oxidored; NADP oxidoreductase coenzyme F420-dependent
XM_017011954.3 → XP_016867443.1 metalloreductase STEAP2 isoform X1

UniProtKB/Swiss-Prot

Q8IUE7, Q8NFT2

Conserved Domains (3) summary

COG2085
Location:32 → 217

COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]

pfam01794
Location:262 → 405

Ferric_reduct; Ferric reductase like transmembrane component

pfam03807
Location:34 → 119

F420_oxidored; NADP oxidoreductase coenzyme F420-dependent
XM_047420178.1 → XP_047276134.1 metalloreductase STEAP2 isoform X2
XM_047420177.1 → XP_047276133.1 metalloreductase STEAP2 isoform X2
XM_017011955.2 → XP_016867444.1 metalloreductase STEAP2 isoform X2
XM_047420176.1 → XP_047276132.1 metalloreductase STEAP2 isoform X2
XM_047420179.1 → XP_047276135.1 metalloreductase STEAP2 isoform X2
XM_047420181.1 → XP_047276137.1 metalloreductase STEAP2 isoform X3

UniProtKB/TrEMBL

Q6YPB2
XM_017011958.3 → XP_016867447.1 metalloreductase STEAP2 isoform X4