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STEAP2 STEAP2 metalloreductase [ Homo sapiens (human) ]

Gene ID: 261729, updated on 17-Jun-2019

Summary

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Official Symbol
STEAP2provided by HGNC
Official Full Name
STEAP2 metalloreductaseprovided by HGNC
Primary source
HGNC:HGNC:17885
See related
Ensembl:ENSG00000157214 MIM:605094
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STMP; IPCA1; PUMPCn; STAMP1; PCANAP1
Summary
This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Expression
Biased expression in prostate (RPKM 47.3), gall bladder (RPKM 4.2) and 6 other tissues See more
Orthologs
mouse all

Genomic context

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See STEAP2 in Genome Data Viewer
Location:
7q21.13
Exon count:
9
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (90211740..90243408)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (89841000..89866992)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene STEAP2 antisense RNA 1 Neighboring gene DPY19L2 pseudogene 4 Neighboring gene STEAP family member 1 Neighboring gene uncharacterized LOC107986819 Neighboring gene cilia and flagella associated protein 69 Neighboring gene uncharacterized LOC107986715 Neighboring gene uncharacterized LOC101927446 Neighboring gene family with sequence similarity 237 member B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. A role for STEAP2 in prostate cancer progression. Whiteland H, et al. Clin Exp Metastasis, 2014 Dec. PMID 25248617
  2. STAMP1 is both a proliferative and an antiapoptotic factor in prostate cancer. Wang L, et al. Cancer Res, 2010 Jul 15. PMID 20587517
  3. Molecular cloning and characterization of STAMP2, an androgen-regulated six transmembrane protein that is overexpressed in prostate cancer. Korkmaz CG, et al. Oncogene, 2005 Jul 21. PMID 15897894
  4. ACRATA: a novel electron transfer domain associated to apoptosis and cancer. Sanchez-Pulido L, et al. BMC Cancer, 2004 Dec 29. PMID 15623366, Free PMC Article
  5. Prediction of gene function by genome-scale expression analysis: prostate cancer-associated genes. Walker MG, et al. Genome Res, 1999 Dec. PMID 10613842, Free PMC Article

See all (16) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

  1. Over-expression of STEAP2 is associated with prostate cancer progression.
    Title: A role for STEAP2 in prostate cancer progression.
  2. Data suggest that STAMP1 is required for prostate cancer growth.
    Title: STAMP1 is both a proliferative and an antiapoptotic factor in prostate cancer.
  3. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  4. STEAPs may represent novel markers of mesenchymal stem cells in man as well as mice.
    Title: Six-transmembrane epithelial antigen of the prostate (STEAP1 and STEAP2)-differentially expressed by murine and human mesenchymal stem cells.
  5. STEAP2 is involved in the development of prostate cancer. As a cell-surface antigen, it is a potential diagnostic or therapeutic target in prostate cancer.
    Title: Cloning and characterization of a novel six-transmembrane protein STEAP2, expressed in normal and malignant prostate.
  6. cloning and characterization of STAMP1, which is expressed in both normal prostate and prostate neoplasms
    Title: Molecular cloning and characterization of STAMP1, a highly prostate-specific six transmembrane protein that is overexpressed in prostate cancer.
  7. The murine ortholog, Steap2, is a ferrireductase, cupric reductase, and stimulates cellular uptake of both iron and copper in vitro.
    Title: The Steap proteins are metalloreductases.
  8. Expression of STAMP2, a gene highly similar to STAMP1 (STEAP2), in prostate cancer cells significantly increases cell growth and colony formation suggesting that STAMP2 may have a role in cell proliferation.
    Title: Molecular cloning and characterization of STAMP2, an androgen-regulated six transmembrane protein that is overexpressed in prostate cancer.
Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Pathways from BioSystems

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  • Copper homeostasis, organism-specific biosystem (from WikiPathways)
    Copper homeostasis, organism-specific biosystemCopper is a redox-active transition metal and an essential trace element for life. It is a catalytic cofactor for numerous enzymes involved in critical biological processes (eg. detoxyfication by oxy...
  • Iron uptake and transport, organism-specific biosystem (from REACTOME)
    Iron uptake and transport, organism-specific biosystemThe transport of iron between cells is mediated by transferrin. However, iron can also enter and leave cells not only by itself, but also in the form of heme and siderophores. When entering the cell ...
  • Mineral absorption, organism-specific biosystem (from KEGG)
    Mineral absorption, organism-specific biosystemMinerals are one of the five fundamental groups of nutrients needed to sustain life. Of the minerals, calcium plays innumerable roles in our bodies, serving as a main component of bone as well as an ...
  • Mineral absorption, conserved biosystem (from KEGG)
    Mineral absorption, conserved biosystemMinerals are one of the five fundamental groups of nutrients needed to sustain life. Of the minerals, calcium plays innumerable roles in our bodies, serving as a main component of bone as well as an ...
  • Transferrin endocytosis and recycling, organism-specific biosystem (from REACTOME)
    Transferrin endocytosis and recycling, organism-specific biosystemEndocytosis of iron loaded transferrin/receptor complex leads, after acidification of the endosome, to the separation of iron and its diffusion out of the vesicle. The endosome is not fused with a ly...
  • Transmembrane transport of small molecules, organism-specific biosystem (from REACTOME)
    Transmembrane transport of small molecules, organism-specific biosystem
    Transmembrane transport of small molecules

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cupric reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
ferric-chelate reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
Golgi to plasma membrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
copper ion import IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
ferric iron import across cell outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
iron ion homeostasis IEA
Inferred from Electronic Annotation
more info
  
oxidation-reduction process IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
regulated exocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
response to hormone IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
endosome IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
endosome membrane IEA
Inferred from Electronic Annotation
more info
  
integral component of Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
trans-Golgi network transport vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
metalloreductase STEAP2
Names
STEAP family member 2, metalloreductase
SixTransMembrane Protein of Prostate 1
prostate cancer-associated protein 1
protein up-regulated in metastatic prostate cancer
protein upregulated in metastatic prostate cancer
six transmembrane epithelial antigen of the prostate 2
six-transmembrane epithelial antigen of prostate 2
NP_001035755.1
NP_001035756.1
NP_001231873.1
NP_001231874.1
NP_001231875.1
NP_694544.2
XP_006715984.1
XP_016867442.1
XP_016867443.1
XP_016867444.1
XP_016867445.1
XP_016867446.1
XP_016867447.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040665.2 → NP_001035755.1  metalloreductase STEAP2 isoform a

    See identical proteins and their annotated locations for NP_001035755.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 4 encode the same isoform.
    Source sequence(s)
    AC002064, AK092666, AY008443, AY008444
    Consensus CDS
    CCDS5615.1
    UniProtKB/Swiss-Prot
    Q8NFT2
    UniProtKB/TrEMBL
    B3KS24, Q6YPB2
    Related
    ENSP00000378120.2, ENST00000394622.6
    Conserved Domains (3) summary
    COG2085
    Location:32 → 217
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:262 → 405
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam03807
    Location:34 → 119
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent

  2. NM_001040666.1 → NP_001035756.1  metalloreductase STEAP2 isoform b

    See identical proteins and their annotated locations for NP_001035756.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, 3' UTR, and 3' coding region compared to variant 1, resulting in a protein (isoform b) that is shorter and has a unique C-terminus, compared to isoform a.
    Source sequence(s)
    AF526382, AK092666, AY008443
    Consensus CDS
    CCDS43612.1
    UniProtKB/Swiss-Prot
    Q8NFT2
    UniProtKB/TrEMBL
    B3KS24, Q6YPB2
    Related
    ENSP00000378125.2, ENST00000394629.2
    Conserved Domains (3) summary
    COG2085
    Location:32 → 217
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:262 → 405
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam03807
    Location:34 → 119
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent

  3. NM_001244944.2 → NP_001231873.1  metalloreductase STEAP2 isoform a

    See identical proteins and their annotated locations for NP_001231873.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 4 encode the same isoform.
    Source sequence(s)
    AC002064
    Consensus CDS
    CCDS5615.1
    UniProtKB/Swiss-Prot
    Q8NFT2
    Related
    ENSP00000378119.2, ENST00000394621.7
    Conserved Domains (3) summary
    COG2085
    Location:32 → 217
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:262 → 405
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam03807
    Location:34 → 119
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent

  4. NM_001244945.2 → NP_001231874.1  metalloreductase STEAP2 isoform b

    See identical proteins and their annotated locations for NP_001231874.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 3' UTR, and 3' coding region compared to variant 1, resulting in a protein (isoform b) that is shorter and has a unique C-terminus, compared to isoform a.
    Source sequence(s)
    AC002064
    Consensus CDS
    CCDS43612.1
    UniProtKB/TrEMBL
    Q6YPB2
    Related
    ENSP00000378123.1, ENST00000394626.5
    Conserved Domains (3) summary
    COG2085
    Location:32 → 217
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:262 → 405
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam03807
    Location:34 → 119
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent

  5. NM_001244946.2 → NP_001231875.1  metalloreductase STEAP2 isoform c

    See identical proteins and their annotated locations for NP_001231875.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, 3' UTR, and 3' coding region compared to variant 1, resulting in a protein (isoform c) that is shorter and has a unique C-terminus, compared to isoform a.
    Source sequence(s)
    AC002064
    Consensus CDS
    CCDS59064.1
    UniProtKB/Swiss-Prot
    Q8NFT2
    Related
    ENSP00000378128.1, ENST00000394632.5
    Conserved Domains (3) summary
    COG2085
    Location:32 → 217
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:262 → 401
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam03807
    Location:34 → 119
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent

  6. NM_152999.4 → NP_694544.2  metalloreductase STEAP2 isoform a

    See identical proteins and their annotated locations for NP_694544.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1, 2 and 4 encode the same isoform.
    Source sequence(s)
    AC002064, AF455138, AK092666, AY008443, DR005432
    Consensus CDS
    CCDS5615.1
    UniProtKB/Swiss-Prot
    Q8NFT2
    UniProtKB/TrEMBL
    B3KS24, Q6YPB2
    Related
    ENSP00000287908.3, ENST00000287908.7
    Conserved Domains (3) summary
    COG2085
    Location:32 → 217
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:262 → 405
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam03807
    Location:34 → 119
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    90211740..90243408
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006715921.4 → XP_006715984.1  metalloreductase STEAP2 isoform X1

    See identical proteins and their annotated locations for XP_006715984.1

    UniProtKB/Swiss-Prot
    Q8NFT2
    Conserved Domains (3) summary
    COG2085
    Location:32 → 217
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:262 → 405
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam03807
    Location:34 → 119
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent

  2. XM_017011956.2 → XP_016867445.1  metalloreductase STEAP2 isoform X3

    UniProtKB/TrEMBL
    Q6YPB2
    Conserved Domains (3) summary
    COG2085
    Location:32 → 217
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:262 → 405
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam03807
    Location:34 → 119
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent

  3. XM_017011953.2 → XP_016867442.1  metalloreductase STEAP2 isoform X1

    UniProtKB/Swiss-Prot
    Q8NFT2
    Conserved Domains (3) summary
    COG2085
    Location:32 → 217
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:262 → 405
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam03807
    Location:34 → 119
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent

  4. XM_017011954.2 → XP_016867443.1  metalloreductase STEAP2 isoform X1

    UniProtKB/Swiss-Prot
    Q8NFT2
    Conserved Domains (3) summary
    COG2085
    Location:32 → 217
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:262 → 405
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam03807
    Location:34 → 119
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent

  5. XM_017011955.1 → XP_016867444.1  metalloreductase STEAP2 isoform X2

  6. XM_017011957.1 → XP_016867446.1  metalloreductase STEAP2 isoform X3

    UniProtKB/TrEMBL
    Q6YPB2
    Conserved Domains (3) summary
    COG2085
    Location:32 → 217
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:262 → 405
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam03807
    Location:34 → 119
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent

  7. XM_017011958.2 → XP_016867447.1  metalloreductase STEAP2 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NFT2.3 GenPept UniProtKB/Swiss-Prot:Q8NFT2

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