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STEAP2 STEAP2 metalloreductase [ Homo sapiens (human) ]

Gene ID: 261729, updated on 11-Jul-2021

Summary

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Official Symbol
STEAP2provided by HGNC
Official Full Name
STEAP2 metalloreductaseprovided by HGNC
Primary source
HGNC:HGNC:17885
See related
Ensembl:ENSG00000157214 MIM:605094
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
STMP; IPCA1; PUMPCn; STAMP1; PCANAP1
Summary
This gene is a member of the STEAP family and encodes a multi-pass membrane protein that localizes to the Golgi complex, the plasma membrane, and the vesicular tubular structures in the cytosol. A highly similar protein in mouse has both ferrireductase and cupric reductase activity, and stimulates the cellular uptake of both iron and copper in vitro. Increased transcriptional expression of the human gene is associated with prostate cancer progression. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Expression
Biased expression in prostate (RPKM 47.3), gall bladder (RPKM 4.2) and 6 other tissues See more
Orthologs
mouse all
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Genomic context

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See STEAP2 in Genome Data Viewer
Location:
7q21.13
Exon count:
9
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (90211740..90243408)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (89841054..89866997)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene STEAP2 antisense RNA 1 Neighboring gene DPY19L2 pseudogene 4 Neighboring gene STEAP family member 1 Neighboring gene uncharacterized LOC107986819 Neighboring gene cilia and flagella associated protein 69 Neighboring gene uncharacterized LOC107986715 Neighboring gene uncharacterized LOC101927446 Neighboring gene family with sequence similarity 237 member B

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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Related articles in PubMed

  1. STEAP2 is down-regulated in breast cancer tissue and suppresses PI3K/AKT signaling and breast cancer cell invasion in vitro and in vivo. Yang Q, et al. Cancer Biol Ther, 2020. PMID 31696760, Free PMC Article
  2. STEAP2 Knockdown Reduces the Invasive Potential of Prostate Cancer Cells. Burnell SEA, et al. Sci Rep, 2018 Apr 19. PMID 29674723, Free PMC Article
  3. A role for STEAP2 in prostate cancer progression. Whiteland H, et al. Clin Exp Metastasis, 2014 Dec. PMID 25248617
  4. STAMP1 is both a proliferative and an antiapoptotic factor in prostate cancer. Wang L, et al. Cancer Res, 2010 Jul 15. PMID 20587517
  5. Membrane cholesterol modulates STEAP2 conformation during dynamic intracellular trafficking processes leading to broad subcellular distribution. Hasegawa H, et al. Exp Cell Res, 2018 Sep 15. PMID 29940176

See all (22) citations in PubMed

See citations in PubMed for homologs of this gene provided by HomoloGene

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. STEAP2 is down-regulated in breast cancer tissue and suppresses PI3K/AKT signaling and breast cancer cell invasion in vitro and in vivo.
    Title: STEAP2 is down-regulated in breast cancer tissue and suppresses PI3K/AKT signaling and breast cancer cell invasion in vitro and in vivo.
  2. The Tumor Suppressive Roles and Prognostic Values of STEAP Family Members in Breast Cancer.
    Title: The Tumor Suppressive Roles and Prognostic Values of STEAP Family Members in Breast Cancer.
  3. STEAP2 drives aggressive prostate cancer traits by promoting proliferation, migration and invasion and significantly influencing the transcriptional profile of ten genes underlying the metastatic cascade.
    Title: STEAP2 Knockdown Reduces the Invasive Potential of Prostate Cancer Cells.
  4. The conformational modulation of STEAP2 by the local membrane cholesterol content can therefore serve as a potential mechanism to modulate STEAP2 function in a compartment-restricted manner
    Title: Membrane cholesterol modulates STEAP2 conformation during dynamic intracellular trafficking processes leading to broad subcellular distribution.
  5. Over-expression of STEAP2 is associated with prostate cancer progression.
    Title: A role for STEAP2 in prostate cancer progression.
  6. Data suggest that STAMP1 is required for prostate cancer growth.
    Title: STAMP1 is both a proliferative and an antiapoptotic factor in prostate cancer.
  7. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  8. STEAPs may represent novel markers of mesenchymal stem cells in man as well as mice.
    Title: Six-transmembrane epithelial antigen of the prostate (STEAP1 and STEAP2)-differentially expressed by murine and human mesenchymal stem cells.
  9. STEAP2 is involved in the development of prostate cancer. As a cell-surface antigen, it is a potential diagnostic or therapeutic target in prostate cancer.
    Title: Cloning and characterization of a novel six-transmembrane protein STEAP2, expressed in normal and malignant prostate.
  10. cloning and characterization of STAMP1, which is expressed in both normal prostate and prostate neoplasms
    Title: Molecular cloning and characterization of STAMP1, a highly prostate-specific six transmembrane protein that is overexpressed in prostate cancer.
Submit: New GeneRIF Correction See all GeneRIFs (12)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Genotypes

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables cupric reductase activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables ferric-chelate reductase (NADPH) activity IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Golgi to plasma membrane transport IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in copper ion import IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
involved_in copper ion import across plasma membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in endocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in iron ion import across plasma membrane IEA
Inferred from Electronic Annotation
more info
  
involved_in regulated exocytosis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in response to hormone IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in early endosome IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in endosome IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in endosome membrane IEA
Inferred from Electronic Annotation
more info
  
located_in integral component of Golgi membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
 PubMed 
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in trans-Golgi network transport vesicle IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
metalloreductase STEAP2
Names
STEAP family member 2, metalloreductase
SixTransMembrane Protein of Prostate 1
prostate cancer-associated protein 1
protein up-regulated in metastatic prostate cancer
protein upregulated in metastatic prostate cancer
six transmembrane epithelial antigen of the prostate 2
six-transmembrane epithelial antigen of prostate 2
NP_001035755.1
NP_001035756.1
NP_001231873.1
NP_001231874.1
NP_001231875.1
NP_694544.2
XP_006715984.1
XP_016867442.1
XP_016867443.1
XP_016867444.1
XP_016867445.1
XP_016867446.1
XP_016867447.1

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001040665.2 → NP_001035755.1  metalloreductase STEAP2 isoform a

    See identical proteins and their annotated locations for NP_001035755.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 4 encode the same isoform.
    Source sequence(s)
    AC002064, AK092666, AY008443, AY008444
    Consensus CDS
    CCDS5615.1
    UniProtKB/Swiss-Prot
    Q8NFT2
    UniProtKB/TrEMBL
    B3KS24, Q6YPB2
    Related
    ENSP00000378120.2, ENST00000394622.6
    Conserved Domains (3) summary
    COG2085
    Location:32 → 217
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:262 → 405
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam03807
    Location:34 → 119
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent

  2. NM_001040666.2 → NP_001035756.1  metalloreductase STEAP2 isoform b

    See identical proteins and their annotated locations for NP_001035756.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, 3' UTR, and 3' coding region compared to variant 1, resulting in a protein (isoform b) that is shorter and has a unique C-terminus, compared to isoform a.
    Source sequence(s)
    AC002064, AF526382, AK092666, AY008443
    Consensus CDS
    CCDS43612.1
    UniProtKB/Swiss-Prot
    Q8NFT2
    UniProtKB/TrEMBL
    B3KS24, Q6YPB2
    Related
    ENSP00000378125.2, ENST00000394629.2
    Conserved Domains (3) summary
    COG2085
    Location:32 → 217
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:262 → 405
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam03807
    Location:34 → 119
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent

  3. NM_001244944.2 → NP_001231873.1  metalloreductase STEAP2 isoform a

    See identical proteins and their annotated locations for NP_001231873.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 4 encode the same isoform.
    Source sequence(s)
    AC002064
    Consensus CDS
    CCDS5615.1
    UniProtKB/Swiss-Prot
    Q8NFT2
    Related
    ENSP00000378119.2, ENST00000394621.7
    Conserved Domains (3) summary
    COG2085
    Location:32 → 217
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:262 → 405
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam03807
    Location:34 → 119
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent

  4. NM_001244945.2 → NP_001231874.1  metalloreductase STEAP2 isoform b

    See identical proteins and their annotated locations for NP_001231874.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 3' UTR, and 3' coding region compared to variant 1, resulting in a protein (isoform b) that is shorter and has a unique C-terminus, compared to isoform a.
    Source sequence(s)
    AC002064
    Consensus CDS
    CCDS43612.1
    UniProtKB/TrEMBL
    Q6YPB2
    Related
    ENSP00000378123.1, ENST00000394626.5
    Conserved Domains (3) summary
    COG2085
    Location:32 → 217
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:262 → 405
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam03807
    Location:34 → 119
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent

  5. NM_001244946.2 → NP_001231875.1  metalloreductase STEAP2 isoform c

    See identical proteins and their annotated locations for NP_001231875.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, 3' UTR, and 3' coding region compared to variant 1, resulting in a protein (isoform c) that is shorter and has a unique C-terminus, compared to isoform a.
    Source sequence(s)
    AC002064
    Consensus CDS
    CCDS59064.1
    UniProtKB/Swiss-Prot
    Q8NFT2
    Related
    ENSP00000378128.1, ENST00000394632.5
    Conserved Domains (3) summary
    COG2085
    Location:32 → 217
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:262 → 401
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam03807
    Location:34 → 119
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent

  6. NM_152999.4 → NP_694544.2  metalloreductase STEAP2 isoform a

    See identical proteins and their annotated locations for NP_694544.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a). Variants 1, 2 and 4 encode the same isoform.
    Source sequence(s)
    AC002064, AF455138, AK092666, AY008443, DR005432
    Consensus CDS
    CCDS5615.1
    UniProtKB/Swiss-Prot
    Q8NFT2
    UniProtKB/TrEMBL
    B3KS24, Q6YPB2
    Related
    ENSP00000287908.3, ENST00000287908.7
    Conserved Domains (3) summary
    COG2085
    Location:32 → 217
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:262 → 405
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam03807
    Location:34 → 119
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    90211740..90243408
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006715921.4 → XP_006715984.1  metalloreductase STEAP2 isoform X1

    See identical proteins and their annotated locations for XP_006715984.1

    UniProtKB/Swiss-Prot
    Q8NFT2
    Conserved Domains (3) summary
    COG2085
    Location:32 → 217
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:262 → 405
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam03807
    Location:34 → 119
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent

  2. XM_017011956.2 → XP_016867445.1  metalloreductase STEAP2 isoform X3

    UniProtKB/TrEMBL
    Q6YPB2
    Conserved Domains (3) summary
    COG2085
    Location:32 → 217
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:262 → 405
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam03807
    Location:34 → 119
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent

  3. XM_017011953.2 → XP_016867442.1  metalloreductase STEAP2 isoform X1

    UniProtKB/Swiss-Prot
    Q8NFT2
    Conserved Domains (3) summary
    COG2085
    Location:32 → 217
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:262 → 405
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam03807
    Location:34 → 119
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent

  4. XM_017011954.2 → XP_016867443.1  metalloreductase STEAP2 isoform X1

    UniProtKB/Swiss-Prot
    Q8NFT2
    Conserved Domains (3) summary
    COG2085
    Location:32 → 217
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:262 → 405
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam03807
    Location:34 → 119
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent

  5. XM_017011955.1 → XP_016867444.1  metalloreductase STEAP2 isoform X2

  6. XM_017011957.1 → XP_016867446.1  metalloreductase STEAP2 isoform X3

    UniProtKB/TrEMBL
    Q6YPB2
    Conserved Domains (3) summary
    COG2085
    Location:32 → 217
    COG2085; Predicted dinucleotide-binding enzyme [General function prediction only]
    pfam01794
    Location:262 → 405
    Ferric_reduct; Ferric reductase like transmembrane component
    pfam03807
    Location:34 → 119
    F420_oxidored; NADP oxidoreductase coenzyme F420-dependent

  7. XM_017011958.2 → XP_016867447.1  metalloreductase STEAP2 isoform X4

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8NFT2.3 GenPept UniProtKB/Swiss-Prot:Q8NFT2

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