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TIPRL TOR signaling pathway regulator [ Homo sapiens (human) ]

Gene ID: 261726, updated on 24-Nov-2020

Summary

Official Symbol
TIPRLprovided by HGNC
Official Full Name
TOR signaling pathway regulatorprovided by HGNC
Primary source
HGNC:HGNC:30231
See related
Ensembl:ENSG00000143155 MIM:611807
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TIP; TIP41; TIPRL1
Summary
TIPRL is an inhibitory regulator of protein phosphatase-2A (PP2A) (see PPP2CA; MIM 176915), PP4 (see PPP4C; MIM 602035), and PP6 (see PPP6C; MIM 612725) (McConnell et al., 2007 [PubMed 17384681]).[supplied by OMIM, Nov 2010]
Expression
Ubiquitous expression in endometrium (RPKM 11.7), brain (RPKM 11.6) and 25 other tissues See more
Orthologs

Genomic context

See TIPRL in Genome Data Viewer
Location:
1q24.2
Exon count:
8
Annotation release Status Assembly Chr Location
109.20201120 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (168178962..168202109)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (168148171..168171352)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene DDB1 and CUL4 associated factor 6 Neighboring gene glycine cleavage system protein H pseudogene 5 Neighboring gene G protein-coupled receptor 161 Neighboring gene cytochrome c oxidase subunit NDUFA4 pseudogene Neighboring gene ribosomal protein L34 pseudogene 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC3794

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
DNA damage checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
TOR signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of phosphoprotein phosphatase activity IDA
Inferred from Direct Assay
more info
PubMed 
regulation of phosphoprotein phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
TIP41-like protein
Names
TIP41, TOR signaling pathway regulator-like
putative MAPK-activating protein PM10
type 2A-interacting protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001031800.3NP_001026970.1  TIP41-like protein isoform 2

    See identical proteins and their annotated locations for NP_001026970.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks several exons, and uses an alternate 3'-terminal exon, compared to variant 1. This results in a novel 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AK313520, BC009506
    Consensus CDS
    CCDS30935.1
    UniProtKB/Swiss-Prot
    O75663
    Related
    ENSP00000356804.3, ENST00000367830.3
    Conserved Domains (1) summary
    pfam04176
    Location:56172
    TIP41; TIP41-like family
  2. NM_152902.5NP_690866.1  TIP41-like protein isoform 1

    See identical proteins and their annotated locations for NP_690866.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK313520, AL021397
    Consensus CDS
    CCDS1270.1
    UniProtKB/Swiss-Prot
    O75663
    Related
    ENSP00000356807.2, ENST00000367833.7
    Conserved Domains (1) summary
    pfam04176
    Location:50218
    TIP41; TIP41-like family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20201120

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    168178962..168202109
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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