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GIMAP2 GTPase, IMAP family member 2 [ Homo sapiens (human) ]

Gene ID: 26157, updated on 11-Jun-2021

Summary

Official Symbol
GIMAP2provided by HGNC
Official Full Name
GTPase, IMAP family member 2provided by HGNC
Primary source
HGNC:HGNC:21789
See related
Ensembl:ENSG00000106560 MIM:608085
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
IAN12; IMAP2; HIMAP2
Summary
This gene encodes a protein belonging to the GTP-binding superfamily and to the immuno-associated nucleotide (IAN) subfamily of nucleotide-binding proteins. In humans, the IAN subfamily genes are located in a cluster at 7q36.1. [provided by RefSeq, Jul 2008]
Expression
Broad expression in lymph node (RPKM 31.9), spleen (RPKM 29.6) and 22 other tissues See more
Orthologs
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Genomic context

See GIMAP2 in Genome Data Viewer
Location:
7q36.1
Exon count:
3
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 7 NC_000007.14 (150685706..150693641)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (150382794..150390729)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene GTPase, IMAP family member 6 Neighboring gene eukaryotic translation initiation factor 2A pseudogene 3 Neighboring gene GIMAP1-GIMAP5 readthrough Neighboring gene GTPase, IMAP family member 1 Neighboring gene GTPase, IMAP family member 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of smoking behaviours in patients with COPD.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: GIMAP1

Homology

Clone Names

  • MGC24275, DKFZp586D0824

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
 
enables identical protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in lipid droplet IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
GTPase IMAP family member 2
Names
immune-associated nucleotide-binding protein 12
immunity associated protein 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015660.3NP_056475.1  GTPase IMAP family member 2

    See identical proteins and their annotated locations for NP_056475.1

    Status: REVIEWED

    Source sequence(s)
    BC032345, BG687383
    Consensus CDS
    CCDS5905.1
    UniProtKB/Swiss-Prot
    Q9UG22
    UniProtKB/TrEMBL
    A0A090N8H4
    Related
    ENSP00000223293.5, ENST00000223293.10
    Conserved Domains (1) summary
    cd01852
    Location:23224
    AIG1; AvrRpt2-Induced Gene 1 (AIG1)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p13 Primary Assembly

    Range
    150685706..150693641
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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