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NOC2L NOC2 like nucleolar associated transcriptional repressor [ Homo sapiens (human) ]

Gene ID: 26155, updated on 1-Jun-2020

Summary

Official Symbol
NOC2Lprovided by HGNC
Official Full Name
NOC2 like nucleolar associated transcriptional repressorprovided by HGNC
Primary source
HGNC:HGNC:24517
See related
Ensembl:ENSG00000188976 MIM:610770
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
NIR; NET7; NET15; PPP1R112
Summary
Histone modification by histone acetyltransferases (HAT) and histone deacetylases (HDAC) can control major aspects of transcriptional regulation. NOC2L represents a novel HDAC-independent inhibitor of histone acetyltransferase (INHAT) (Hublitz et al., 2005 [PubMed 16322561]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in testis (RPKM 23.1), skin (RPKM 20.4) and 25 other tissues See more
Orthologs

Genomic context

See NOC2L in Genome Data Viewer
Location:
1p36.33
Exon count:
19
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (944203..959256, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (879583..894679, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2593 Neighboring gene collagen alpha-1(III) chain-like Neighboring gene sterile alpha motif domain containing 11 Neighboring gene kelch like family member 17 Neighboring gene pleckstrin homology domain containing N1 Neighboring gene PPARGC1 and ESRR induced regulator, muscle 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ35172, DKFZp564C186

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
chromatin binding IDA
Inferred from Direct Assay
more info
PubMed 
histone binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
histone binding IDA
Inferred from Direct Assay
more info
PubMed 
nucleosome binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
repressing transcription factor binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
repressing transcription factor binding IDA
Inferred from Direct Assay
more info
PubMed 
transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
apoptotic process IEA
Inferred from Electronic Annotation
more info
 
cellular response to UV IDA
Inferred from Direct Assay
more info
PubMed 
chromatin assembly IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of B cell apoptotic process IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of histone acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of histone acetylation IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of intrinsic apoptotic signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
regulation of signal transduction by p53 class mediator TAS
Traceable Author Statement
more info
 
ribosomal large subunit biogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
Noc1p-Noc2p complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Noc2p-Noc3p complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm TAS
Traceable Author Statement
more info
 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
nucleolar complex protein 2 homolog
Names
NOC2-like protein
NOC2L nucleolar associated transcriptional repressor
novel INHAT (inhibitor of histone acetyltransferase) repressor
novel INHAT repressor
nucleolar complex associated 2 homolog
protein NOC2 homolog
protein phosphatase 1, regulatory subunit 12

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015658.4NP_056473.3  nucleolar complex protein 2 homolog

    Status: VALIDATED

    Source sequence(s)
    AL645608
    Consensus CDS
    CCDS3.1
    Related
    ENSP00000317992.6, ENST00000327044.7
    Conserved Domains (1) summary
    pfam03715
    Location:327622
    Noc2; Noc2p family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    944203..959256 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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