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KIF26A kinesin family member 26A [ Homo sapiens (human) ]

Gene ID: 26153, updated on 10-Dec-2024

Summary

Official Symbol
KIF26Aprovided by HGNC
Official Full Name
kinesin family member 26Aprovided by HGNC
Primary source
HGNC:HGNC:20226
See related
Ensembl:ENSG00000066735 MIM:613231; AllianceGenome:HGNC:20226
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CDCBM11
Summary
Predicted to enable microtubule binding activity. Involved in cerebral cortex development; regulation of neuron migration; and regulation of neuron projection development. Predicted to be located in cytosol. Implicated in complex cortical dysplasia with other brain malformations. [provided by Alliance of Genome Resources, Dec 2024]
Expression
Broad expression in fat (RPKM 3.9), spleen (RPKM 2.2) and 20 other tissues See more
Orthologs
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Genomic context

See KIF26A in Genome Data Viewer
Location:
14q32.33
Exon count:
15
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (104138587..104180894)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (98375914..98418495)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (104604924..104647231)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene asparaginase Neighboring gene microRNA 203a Neighboring gene microRNA 203b Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:104600835-104601334 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:104601943-104602516 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:104602803-104603514 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:104603515-104604226 Neighboring gene KIF26A divergent transcript Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:104614982-104615497 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:104617559-104618072 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:104620618-104621118 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:104621119-104621619 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:104635187-104635899 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:104638041-104638754 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:104645533-104646067 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:104655181-104656014 Neighboring gene uncharacterized LOC124903393 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:104688883-104689775 Neighboring gene long intergenic non-protein coding RNA 2691 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:104703975-104704476 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:104705328-104706173 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:104706174-104707018 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:104736421-104737106 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:104737107-104737791 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:104745688-104745903

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • FLJ22753, KIAA1236, DKFZp434N178

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
NOT enables ATP hydrolysis activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables microtubule binding ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT enables microtubule motor activity ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cerebral cortex development IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in enteric nervous system development ISS
Inferred from Sequence or Structural Similarity
more info
 
NOT involved_in microtubule-based movement ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in negative regulation of signal transduction ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cell growth by extracellular stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of neuron migration IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of neuron projection development IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in microtubule IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
kinesin-like protein KIF26A
Names
KIF26A variant protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015656.2NP_056471.1  kinesin-like protein KIF26A

    See identical proteins and their annotated locations for NP_056471.1

    Status: VALIDATED

    Source sequence(s)
    AL359399
    Consensus CDS
    CCDS45171.1
    UniProtKB/Swiss-Prot
    Q8TAZ7, Q96GK3, Q9UFL3, Q9ULI4
    UniProtKB/TrEMBL
    B0I1R4
    Related
    ENSP00000388241.2, ENST00000423312.7
    Conserved Domains (4) summary
    smart00129
    Location:372731
    KISc; Kinesin motor, catalytic domain. ATPase
    COG3416
    Location:15521673
    COG3416; Uncharacterized protein [Function unknown]
    PRK07764
    Location:8441285
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd00106
    Location:371723
    KISc; Kinesin motor domain

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

    Range
    104138587..104180894
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536641.3XP_011534943.1  kinesin-like protein KIF26A isoform X1

    UniProtKB/TrEMBL
    C9JFF0
    Conserved Domains (4) summary
    smart00129
    Location:63422
    KISc; Kinesin motor, catalytic domain. ATPase
    COG3416
    Location:12431364
    COG3416; Uncharacterized protein [Function unknown]
    PRK07764
    Location:535969
    PRK07764; DNA polymerase III subunits gamma and tau; Validated
    cd00106
    Location:62414
    KISc; Kinesin motor domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060938.1 Alternate T2T-CHM13v2.0

    Range
    98375914..98418495
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054375846.1XP_054231821.1  kinesin-like protein KIF26A isoform X1

    UniProtKB/TrEMBL
    C9JFF0