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ZNF337 zinc finger protein 337 [ Homo sapiens (human) ]

Gene ID: 26152, updated on 11-Jun-2021

Summary

Official Symbol
ZNF337provided by HGNC
Official Full Name
zinc finger protein 337provided by HGNC
Primary source
HGNC:HGNC:15809
See related
Ensembl:ENSG00000130684
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This gene encodes a zinc finger domain containing protein. The function of this protein has yet to be determined. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]
Expression
Ubiquitous expression in ovary (RPKM 5.9), endometrium (RPKM 5.8) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF337 in Genome Data Viewer
Location:
20p11.21
Exon count:
6
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (25673195..25696879, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (25653831..25677489, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ZNF337 antisense RNA 1 Neighboring gene RNA, 7SL, cytoplasmic 594, pseudogene Neighboring gene mediator complex subunit 28 pseudogene 7 Neighboring gene uncharacterized LOC107985400 Neighboring gene vomeronasal 1 receptor 108 pseudogene Neighboring gene uncharacterized LOC105372582

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in negative regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_034058.1 RefSeqGene

    Range
    5052..28710
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001290261.2NP_001277190.1  zinc finger protein 337

    See identical proteins and their annotated locations for NP_001277190.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK125455, AL031673, BC021298, BX113975
    Consensus CDS
    CCDS13174.1
    UniProtKB/Swiss-Prot
    Q9Y3M9
    UniProtKB/TrEMBL
    Q6ZUQ0
    Related
    ENSP00000365619.1, ENST00000376436.5
    Conserved Domains (7) summary
    smart00349
    Location:1271
    KRAB; krueppel associated box
    COG5048
    Location:234626
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:350370
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:348370
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:1251
    KRAB; KRAB box
    pfam13465
    Location:530554
    zf-H2C2_2; Zinc-finger double domain
    pfam13834
    Location:600633
    DUF4193; Domain of unknown function (DUF4193)
  2. NM_015655.4NP_056470.1  zinc finger protein 337

    See identical proteins and their annotated locations for NP_056470.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK291235, AL031673, BC021298, BP201424, BX113975
    Consensus CDS
    CCDS13174.1
    UniProtKB/Swiss-Prot
    Q9Y3M9
    UniProtKB/TrEMBL
    A8K5C0
    Related
    ENSP00000252979.5, ENST00000252979.6
    Conserved Domains (7) summary
    smart00349
    Location:1271
    KRAB; krueppel associated box
    COG5048
    Location:234626
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:350370
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:348370
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:1251
    KRAB; KRAB box
    pfam13465
    Location:530554
    zf-H2C2_2; Zinc-finger double domain
    pfam13834
    Location:600633
    DUF4193; Domain of unknown function (DUF4193)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    25673195..25696879 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027804.1XP_016883293.1  zinc finger protein 337 isoform X3

  2. XM_017027803.2XP_016883292.1  zinc finger protein 337 isoform X2

    UniProtKB/Swiss-Prot
    Q9Y3M9
    Conserved Domains (7) summary
    smart00349
    Location:1252
    KRAB; krueppel associated box
    COG5048
    Location:202594
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:318338
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:316338
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:1251
    KRAB; KRAB box
    pfam13465
    Location:358383
    zf-H2C2_2; Zinc-finger double domain
    pfam13834
    Location:568601
    DUF4193; Domain of unknown function (DUF4193)
  3. XM_006723558.4XP_006723621.1  zinc finger protein 337 isoform X1

    See identical proteins and their annotated locations for XP_006723621.1

    UniProtKB/Swiss-Prot
    Q9Y3M9
    Conserved Domains (7) summary
    smart00349
    Location:1271
    KRAB; krueppel associated box
    COG5048
    Location:234626
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:350370
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:348370
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:1251
    KRAB; KRAB box
    pfam13465
    Location:530554
    zf-H2C2_2; Zinc-finger double domain
    pfam13834
    Location:600633
    DUF4193; Domain of unknown function (DUF4193)
  4. XM_005260702.3XP_005260759.1  zinc finger protein 337 isoform X2

    See identical proteins and their annotated locations for XP_005260759.1

    UniProtKB/Swiss-Prot
    Q9Y3M9
    Conserved Domains (7) summary
    smart00349
    Location:1252
    KRAB; krueppel associated box
    COG5048
    Location:202594
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:318338
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:316338
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:1251
    KRAB; KRAB box
    pfam13465
    Location:358383
    zf-H2C2_2; Zinc-finger double domain
    pfam13834
    Location:568601
    DUF4193; Domain of unknown function (DUF4193)
  5. XM_011529219.2XP_011527521.1  zinc finger protein 337 isoform X1

    See identical proteins and their annotated locations for XP_011527521.1

    UniProtKB/Swiss-Prot
    Q9Y3M9
    Conserved Domains (7) summary
    smart00349
    Location:1271
    KRAB; krueppel associated box
    COG5048
    Location:234626
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:350370
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:348370
    zf-C2H2; Zinc finger, C2H2 type
    pfam01352
    Location:1251
    KRAB; KRAB box
    pfam13465
    Location:530554
    zf-H2C2_2; Zinc-finger double domain
    pfam13834
    Location:600633
    DUF4193; Domain of unknown function (DUF4193)
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