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ZNF658 zinc finger protein 658 [ Homo sapiens (human) ]

Gene ID: 26149, updated on 17-Sep-2024

Summary

Official Symbol
ZNF658provided by HGNC
Official Full Name
zinc finger protein 658provided by HGNC
Primary source
HGNC:HGNC:25226
See related
Ensembl:ENSG00000274349 MIM:616290; AllianceGenome:HGNC:25226
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables transcription cis-regulatory region binding activity. Involved in cellular response to zinc ion; negative regulation of transcription, DNA-templated; and ribosome biogenesis. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in skin (RPKM 2.5), thyroid (RPKM 2.1) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF658 in Genome Data Viewer
Location:
9q21.11
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (66900725..66932141)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (78672849..78704251)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (40760700..40792116, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene CNTNAP3 pseudogene 9 Neighboring gene S-phase kinase associated protein 1 pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:40713401-40713901 Neighboring gene family with sequence similarity 74 member A3 Neighboring gene SPATA31 subfamily A member 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of zinc finger protein 658 (ZNF658) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317916.2NP_001304845.1  zinc finger protein 658

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK292150, AL110217, AL353770, BX664608, DA103495
    Consensus CDS
    CCDS75846.1
    UniProtKB/Swiss-Prot
    Q5TYW1, Q6PIP3, Q96M55, Q9H9S6, Q9UG02
    Related
    ENSP00000482540.1, ENST00000612867.4
    Conserved Domains (5) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:6281044
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:940960
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:10091033
    zf-H2C2_2; Zinc-finger double domain
  2. NM_033160.7NP_149350.3  zinc finger protein 658

    See identical proteins and their annotated locations for NP_149350.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK057375, AL110217, AL353770, BX664608, DA103495
    Consensus CDS
    CCDS75846.1
    UniProtKB/Swiss-Prot
    Q5TYW1, Q6PIP3, Q96M55, Q9H9S6, Q9UG02
    Related
    ENSP00000482447.1, ENST00000621410.5
    Conserved Domains (5) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:6281044
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:940960
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:10091033
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_134255.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks a 5' exon and contains two alternate exons in the 3' terminus, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL353770, BC031626, BX664608
    Related
    ENST00000622180.4

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

    Range
    66900725..66932141
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047423212.1XP_047279168.1  zinc finger protein 658 isoform X1

    UniProtKB/Swiss-Prot
    Q5TYW1, Q6PIP3, Q96M55, Q9H9S6, Q9UG02
  2. XM_005272515.6XP_005272572.1  zinc finger protein 658 isoform X1

    See identical proteins and their annotated locations for XP_005272572.1

    UniProtKB/Swiss-Prot
    Q5TYW1, Q6PIP3, Q96M55, Q9H9S6, Q9UG02
    Conserved Domains (5) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:6281044
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:940960
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:10091033
    zf-H2C2_2; Zinc-finger double domain
  3. XM_011545679.4XP_011543981.1  zinc finger protein 658 isoform X1

    See identical proteins and their annotated locations for XP_011543981.1

    UniProtKB/Swiss-Prot
    Q5TYW1, Q6PIP3, Q96M55, Q9H9S6, Q9UG02
    Conserved Domains (5) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:6281044
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:940960
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:10091033
    zf-H2C2_2; Zinc-finger double domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060933.1 Alternate T2T-CHM13v2.0

    Range
    78672849..78704251
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054362706.1XP_054218681.1  zinc finger protein 658 isoform X1

    UniProtKB/Swiss-Prot
    Q5TYW1, Q6PIP3, Q96M55, Q9H9S6, Q9UG02
  2. XM_054362704.1XP_054218679.1  zinc finger protein 658 isoform X1

    UniProtKB/Swiss-Prot
    Q5TYW1, Q6PIP3, Q96M55, Q9H9S6, Q9UG02
  3. XM_054362705.1XP_054218680.1  zinc finger protein 658 isoform X1

    UniProtKB/Swiss-Prot
    Q5TYW1, Q6PIP3, Q96M55, Q9H9S6, Q9UG02