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ZNF658 zinc finger protein 658 [ Homo sapiens (human) ]

Gene ID: 26149, updated on 17-Apr-2020

Summary

Official Symbol
ZNF658provided by HGNC
Official Full Name
zinc finger protein 658provided by HGNC
Primary source
HGNC:HGNC:25226
See related
Ensembl:ENSG00000274349 MIM:616290
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Ubiquitous expression in skin (RPKM 2.5), thyroid (RPKM 2.1) and 25 other tissues See more
Orthologs

Genomic context

See ZNF658 in Genome Data Viewer
Location:
9q21.11
Exon count:
9
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (66900725..66932141)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (40771188..40792112, complement)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene CNTNAP3 pseudogene 9 Neighboring gene S-phase kinase associated protein 1 pseudogene Neighboring gene family with sequence similarity 74 member A3 Neighboring gene SPATA31 subfamily A member 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of zinc finger protein 658 (ZNF658) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ32813, MGC35232, DKFZp572C163

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
cellular response to zinc ion IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
ribosome biogenesis IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001317916.1NP_001304845.1  zinc finger protein 658

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the functional protein. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK292150, AL110217, AL353770, BX664608, DA103495
    Consensus CDS
    CCDS75846.1
    UniProtKB/Swiss-Prot
    Q5TYW1
    UniProtKB/TrEMBL
    A8K7Y5
    Related
    ENSP00000482540.1, ENST00000612867.4
    Conserved Domains (5) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:6281044
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:940960
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:10091033
    zf-H2C2_2; Zinc-finger double domain
  2. NM_033160.6NP_149350.3  zinc finger protein 658

    See identical proteins and their annotated locations for NP_149350.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein.
    Source sequence(s)
    AK057375, AL110217, AL353770, BX664608, DA103495
    Consensus CDS
    CCDS75846.1
    UniProtKB/Swiss-Prot
    Q5TYW1
    Related
    ENSP00000482447.1, ENST00000621410.4
    Conserved Domains (5) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:6281044
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:940960
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:10091033
    zf-H2C2_2; Zinc-finger double domain

RNA

  1. NR_134255.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) lacks a 5' exon and contains two alternate exons in the 3' terminus, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AL353770, BC031626, BX664608
    Related
    ENST00000622180.4

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    66900725..66932141
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005272515.5XP_005272572.1  zinc finger protein 658 isoform X1

    See identical proteins and their annotated locations for XP_005272572.1

    UniProtKB/Swiss-Prot
    Q5TYW1
    Conserved Domains (5) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:6281044
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:940960
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:10091033
    zf-H2C2_2; Zinc-finger double domain
  2. XM_017014614.1XP_016870103.1  zinc finger protein 658 isoform X1

    UniProtKB/Swiss-Prot
    Q5TYW1
    Conserved Domains (5) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:6281044
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:940960
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:10091033
    zf-H2C2_2; Zinc-finger double domain
  3. XM_011545679.3XP_011543981.1  zinc finger protein 658 isoform X1

    See identical proteins and their annotated locations for XP_011543981.1

    UniProtKB/Swiss-Prot
    Q5TYW1
    Conserved Domains (5) summary
    smart00349
    Location:868
    KRAB; krueppel associated box
    COG5048
    Location:6281044
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:940960
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam01352
    Location:847
    KRAB; KRAB box
    pfam13465
    Location:10091033
    zf-H2C2_2; Zinc-finger double domain
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