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IRF2BP1 interferon regulatory factor 2 binding protein 1 [ Homo sapiens (human) ]

Gene ID: 26145, updated on 9-Jun-2024

Summary

Official Symbol
IRF2BP1provided by HGNC
Official Full Name
interferon regulatory factor 2 binding protein 1provided by HGNC
Primary source
HGNC:HGNC:21728
See related
Ensembl:ENSG00000170604 MIM:615331; AllianceGenome:HGNC:21728
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Enables transcription corepressor activity and ubiquitin protein ligase activity. Involved in protein polyubiquitination. Acts upstream of or within negative regulation of transcription by RNA polymerase II. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Orthologs
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Genomic context

See IRF2BP1 in Genome Data Viewer
Location:
19q13.32
Exon count:
1
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (45883608..45886141, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (48711051..48713583, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (46386866..46389399, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14823 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10800 Neighboring gene symplekin scaffold protein Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:46329961-46330728 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:46365430-46366068 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14824 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10801 Neighboring gene HNF4 motif-containing MPRA enhancer 173 Neighboring gene forkhead box A3 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:46385156-46385708 Neighboring gene HNF1 motif-containing MPRA enhancer 100 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:46386261-46386812 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:46386813-46387364 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10802 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10803 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14826 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14827 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14828 Neighboring gene Myb related transcription factor, partner of profilin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14829 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10804 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14830 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10805 Neighboring gene nanos C2HC-type zinc finger 2

Genomic regions, transcripts, and products

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General protein information

Preferred Names
interferon regulatory factor 2-binding protein 1
Names
IRF-2-binding protein 1
probable E3 ubiquitin-protein ligase IRF2BP1
probable RING-type E3 ubiquitin transferase IRF2BP1
NP_056464.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015649.3NP_056464.1  interferon regulatory factor 2-binding protein 1

    See identical proteins and their annotated locations for NP_056464.1

    Status: VALIDATED

    Source sequence(s)
    AY278022, DA791039
    Consensus CDS
    CCDS12678.1
    UniProtKB/Swiss-Prot
    Q53EL7, Q6DC95, Q8IU81, Q9BRZ9, Q9Y4P4
    UniProtKB/TrEMBL
    B2RCD8
    Related
    ENSP00000307265.3, ENST00000302165.5
    Conserved Domains (3) summary
    cd16715
    Location:501556
    vRING-HC_IRF2BP1; variant of RING finger, HC subclass, found in interferon regulatory factor 2-binding protein 1 (IRF-2BP1)
    pfam11261
    Location:859
    IRF-2BP1_2; Interferon regulatory factor 2-binding protein zinc finger
    NF033930
    Location:330422
    pneumo_PspA; pneumococcal surface protein A

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

    Range
    45883608..45886141 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060943.1 Alternate T2T-CHM13v2.0

    Range
    48711051..48713583 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)