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IRF2BP1 interferon regulatory factor 2 binding protein 1 [ Homo sapiens (human) ]

Gene ID: 26145, updated on 1-Jun-2020

Summary

Official Symbol
IRF2BP1provided by HGNC
Official Full Name
interferon regulatory factor 2 binding protein 1provided by HGNC
Primary source
HGNC:HGNC:21728
See related
Ensembl:ENSG00000170604 MIM:615331
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Orthologs

Genomic context

See IRF2BP1 in Genome Data Viewer
Location:
19q13.32
Exon count:
1
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (45883608..45886141, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (46386866..46389376, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene HNF4 motif-containing MPRA enhancer 173 Neighboring gene HNF1 motif-containing MPRA enhancer 100 Neighboring gene Myb related transcription factor, partner of profilin Neighboring gene nanos C2HC-type zinc finger 2

Genomic regions, transcripts, and products

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp434M154

Gene Ontology Provided by GOA

Function Evidence Code Pubs
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
transcription corepressor activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription factor binding IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin protein ligase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
protein polyubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nucleoplasm IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
interferon regulatory factor 2-binding protein 1
Names
IRF-2-binding protein 1
probable E3 ubiquitin-protein ligase IRF2BP1
probable RING-type E3 ubiquitin transferase IRF2BP1
NP_056464.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015649.3NP_056464.1  interferon regulatory factor 2-binding protein 1

    See identical proteins and their annotated locations for NP_056464.1

    Status: VALIDATED

    Source sequence(s)
    AY278022, DA791039
    Consensus CDS
    CCDS12678.1
    UniProtKB/Swiss-Prot
    Q8IU81
    Related
    ENSP00000307265.3, ENST00000302165.5
    Conserved Domains (3) summary
    pfam11261
    Location:859
    IRF-2BP1_2; Interferon regulatory factor 2-binding protein zinc finger
    cd16715
    Location:501556
    vRING-HC_IRF2BP1; variant of RING finger, HC subclass, found in interferon regulatory factor 2-binding protein 1 (IRF-2BP1)
    cl26386
    Location:342463
    DNA_pol3_gamma3; DNA polymerase III subunits gamma and tau domain III

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    45883608..45886141 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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