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TES testin LIM domain protein [ Homo sapiens (human) ]

Gene ID: 26136, updated on 9-Dec-2018

Summary

Official Symbol
TESprovided by HGNC
Official Full Name
testin LIM domain proteinprovided by HGNC
Primary source
HGNC:HGNC:14620
See related
Ensembl:ENSG00000135269 MIM:606085
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TESS; TESS-2
Summary
Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a commom fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a testosterone-responsive gene encoding a Sertoli cell secretory protein containing three LIM domains. LIM domains are double zinc-finger motifs that mediate protein-protein interactions between transcription factors, cytoskeletal proteins and signaling proteins. This protein is a negative regulator of cell growth and may act as a tumor suppressor. This scaffold protein may also play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Multiple protein isoforms are encoded by transcript variants of this gene.[provided by RefSeq, Mar 2011]
Expression
Ubiquitous expression in urinary bladder (RPKM 42.6), thyroid (RPKM 41.1) and 23 other tissues See more
Orthologs

Genomic context

See TES in Genome Data Viewer
Location:
7q31.2
Exon count:
8
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (116210493..116258786)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (115850547..115898840)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene VISTA enhancer hs1798 Neighboring gene transcription factor EC Neighboring gene uncharacterized LOC102724434 Neighboring gene uncharacterized LOC105375463 Neighboring gene VISTA enhancer hs2071

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC1146, DKFZp586B2022

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
cadherin binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
zinc ion binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
negative regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
cell junction IDA
Inferred from Direct Assay
more info
 
cytosol IDA
Inferred from Direct Assay
more info
 
focal adhesion HDA PubMed 
focal adhesion IDA
Inferred from Direct Assay
more info
 
nucleus HDA PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
testin
Names
testis derived transcript (3 LIM domains)

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015641.4NP_056456.1  testin isoform 1

    See identical proteins and their annotated locations for NP_056456.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform.
    Source sequence(s)
    AF245356, DC341259
    Consensus CDS
    CCDS5763.1
    UniProtKB/Swiss-Prot
    Q9UGI8
    UniProtKB/TrEMBL
    A4D0U5
    Related
    ENSP00000350937.4, ENST00000358204.8
    Conserved Domains (4) summary
    cd09413
    Location:236293
    LIM1_Testin; The first LIM domain of Testin
    cd09416
    Location:299354
    LIM2_Testin; The second LIM domain of Testin
    cd09419
    Location:361419
    LIM3_Testin; The third LIM domain of Testin
    cd09829
    Location:109196
    PET_testin; The PET domain of Testin
  2. NM_152829.2NP_690042.1  testin isoform 2

    See identical proteins and their annotated locations for NP_690042.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame exon in the 5' UTR and uses a downstream start codon, compared to variant 1. Thus isoform 2 is nine amino acids shorter than isoform 1.
    Source sequence(s)
    AF245357, AK310995
    Consensus CDS
    CCDS5764.1
    UniProtKB/Swiss-Prot
    Q9UGI8
    Related
    ENSP00000377121.2, ENST00000393481.6
    Conserved Domains (4) summary
    cd09413
    Location:227284
    LIM1_Testin; The first LIM domain of Testin
    cd09416
    Location:290345
    LIM2_Testin; The second LIM domain of Testin
    cd09419
    Location:352410
    LIM3_Testin; The third LIM domain of Testin
    cd09829
    Location:100187
    PET_testin; The PET domain of Testin

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

    Range
    116210493..116258786
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005250258.1XP_005250315.1  testin isoform X1

    See identical proteins and their annotated locations for XP_005250315.1

    Conserved Domains (4) summary
    cd09413
    Location:151208
    LIM1_Testin; The first LIM domain of Testin
    cd09416
    Location:214269
    LIM2_Testin; The second LIM domain of Testin
    cd09419
    Location:276334
    LIM3_Testin; The third LIM domain of Testin
    cd09829
    Location:24111
    PET_testin; The PET domain of Testin
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