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TES testin LIM domain protein [ Homo sapiens (human) ]

Gene ID: 26136, updated on 3-Mar-2026
Official Symbol
TESprovided by HGNC
Official Full Name
testin LIM domain proteinprovided by HGNC
Primary source
HGNC:HGNC:14620
See related
Ensembl:ENSG00000135269 MIM:606085; AllianceGenome:HGNC:14620
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TESS; TESS-2
Summary
Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a common fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a testosterone-responsive gene encoding a Sertoli cell secretory protein containing three LIM domains. LIM domains are double zinc-finger motifs that mediate protein-protein interactions between transcription factors, cytoskeletal proteins and signaling proteins. This protein is a negative regulator of cell growth and may act as a tumor suppressor. This scaffold protein may also play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Multiple protein isoforms are encoded by transcript variants of this gene.[provided by RefSeq, Aug 2023]
Expression
Ubiquitous expression in urinary bladder (RPKM 42.6), thyroid (RPKM 41.1) and 23 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See TES in Genome Data Viewer
Location:
7q31.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (116210539..116258783)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (117525529..117573770)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (115850593..115898837)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724407 Neighboring gene VISTA enhancer hs1798 Neighboring gene transcription factor EC Neighboring gene Sharpr-MPRA regulatory region 6568 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:115807196-115807710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:115825203-115826194 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:115826195-115827184 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26526 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18555 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:115850475-115850737 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18553 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26527 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26528 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26529 Neighboring gene uncharacterized LOC124901730 Neighboring gene uncharacterized LOC102724434 Neighboring gene uncharacterized LOC105375463 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26530 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26531 Neighboring gene Sharpr-MPRA regulatory region 1934 Neighboring gene uncharacterized LOC124900233

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. Testin is tightly associated with testicular cell membrane upon its secretion by sertoli cells whose steady-state mRNA level in the testis correlates with the turnover and integrity of inter-testicular cell junctions. Grima J, et al. J Biol Chem, 1997 Mar 7. PMID 9045675
  2. Frequent hypermethylation and loss of heterozygosity of the testis derived transcript gene in ovarian cancer. Qiu H, et al. Cancer Sci, 2010 May. PMID 20180808, Free PMC Article
  3. Comparative gene expression analysis between coronary arteries and internal mammary arteries identifies a role for the TES gene in endothelial cell functions relevant to coronary artery disease. Archacki SR, et al. Hum Mol Genet, 2012 Mar 15. PMID 22156939
  4. Downregulation of TESTIN and its association with cancer history and a tendency toward poor survival in head and neck squamous cell carcinoma. Gunduz E, et al. Arch Otolaryngol Head Neck Surg, 2009 Mar. PMID 19289703
  5. [Expression and clinical significance of TESTIN in primary gastric cancer]. Huang W, et al. Ai Zheng, 2008 Sep. PMID 18799041

See all (116) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. The value of lung function assessment and Testin expression detection in clinicopathological features and prognosis of NSCLC patients.
    Title: The value of lung function assessment and Testin expression detection in clinicopathological features and prognosis of NSCLC patients.
  2. Stress fiber strain recognition by the LIM protein testin is cryptic and mediated by RhoA.
    Title: Stress fiber strain recognition by the LIM protein testin is cryptic and mediated by RhoA.
  3. Chitinase 3-Like 1, Nestin, and Testin Proteins as Novel Biomarkers of Potential Clinical Use in Colorectal Cancer: A Review.
    Title: Chitinase 3-Like 1, Nestin, and Testin Proteins as Novel Biomarkers of Potential Clinical Use in Colorectal Cancer: A Review.
  4. Expression of testin is downregulated in the hearts of patients with dilated cardiomyopathy.
    Title: Testin protects against cardiac hypertrophy by targeting a calcineurin-dependent signalling pathway.
  5. TES-mediated upregulation of the transcription factor DDIT3 is involved in CFP suppression of breast cancer cell growth
    Title: CFP suppresses breast cancer cell growth by TES-mediated upregulation of the transcription factor DDIT3.
  6. These findings provide a better understanding of the development and progression of gastric cancer (GC) and indicate that TES may be used as a potential prognostic marker and therapeutic target for GC patients.
    Title: TES functions as a Mena-dependent tumor suppressor in gastric cancer carcinogenesis and metastasis.
  7. Testin and filamin-C downregulation by acetylated Siah2 increases invasiveness of Helicobacter pylori-infected gastric cancer cells.
    Title: Testin and filamin-C downregulation by acetylated Siah2 increases invasiveness of Helicobacter pylori-infected gastric cancer cells.
  8. validated two new TES cocomplex partners: TGFB1I1 and a short form of the glucocorticoid receptor. TES and TGFB1I1 are shown to oppositely affect cell spreading providing biological validity for their copresence in complexes since they act in similar processes
    Title: Expanding the Interactome of TES by Exploiting TES Modules with Different Subcellular Localizations.
  9. these data indicate that TES functions as a necessary suppressor of colorectal cancer progression by activating p38-MAPK signaling pathways.
    Title: TES inhibits colorectal cancer progression through activation of p38.
  10. testin region (amino acids 52-233) harbouring the PET domain interacts with the C-terminal LIM1-2 domains
    Title: The PET and LIM1-2 domains of testin contribute to intramolecular and homodimeric interactions.
Submit: New GeneRIF Correction See all GeneRIFs (34)

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC1146, DKFZp586B2022

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables cadherin binding HDA PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables zinc ion binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in negative regulation of cell population proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
  
located_in focal adhesion HDA PubMed 
located_in focal adhesion IDA
Inferred from Direct Assay
more info
  
located_in focal adhesion IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus HDA PubMed 
part_of protein-containing complex IDA
Inferred from Direct Assay
more info
 PubMed 
Preferred Names
testin
Names
testis derived transcript (3 LIM domains)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015641.4 → NP_056456.1  testin isoform 1

    See identical proteins and their annotated locations for NP_056456.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform.
    Source sequence(s)
    AF245356, DC341259
    Consensus CDS
    CCDS5763.1
    UniProtKB/Swiss-Prot
    A4D0U6, Q9GZQ1, Q9HAJ9, Q9UGI8
    UniProtKB/TrEMBL
    A4D0U5, B2RDR4
    Related
    ENSP00000350937.4, ENST00000358204.9
    Conserved Domains (4) summary
    cd09413
    Location:236 → 293
    LIM1_Testin; The first LIM domain of Testin
    cd09416
    Location:299 → 354
    LIM2_Testin; The second LIM domain of Testin
    cd09419
    Location:361 → 419
    LIM3_Testin; The third LIM domain of Testin
    cd09829
    Location:109 → 196
    PET_testin; The PET domain of Testin

  2. NM_152829.3 → NP_690042.1  testin isoform 2

    See identical proteins and their annotated locations for NP_690042.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame exon in the 5' UTR and uses a downstream start codon, compared to variant 1. Thus isoform 2 is nine amino acids shorter than isoform 1.
    Source sequence(s)
    AF245357, AK310995
    Consensus CDS
    CCDS5764.1
    UniProtKB/TrEMBL
    B2RDR4
    Related
    ENSP00000377121.2, ENST00000393481.6
    Conserved Domains (4) summary
    cd09413
    Location:227 → 284
    LIM1_Testin; The first LIM domain of Testin
    cd09416
    Location:290 → 345
    LIM2_Testin; The second LIM domain of Testin
    cd09419
    Location:352 → 410
    LIM3_Testin; The third LIM domain of Testin
    cd09829
    Location:100 → 187
    PET_testin; The PET domain of Testin

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    116210539..116258783
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    117525529..117573770
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9UGI8.1 GenPept UniProtKB/Swiss-Prot:Q9UGI8

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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