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TES testin LIM domain protein [ Homo sapiens (human) ]

Gene ID: 26136, updated on 10-Dec-2024

Summary

Official Symbol
TESprovided by HGNC
Official Full Name
testin LIM domain proteinprovided by HGNC
Primary source
HGNC:HGNC:14620
See related
Ensembl:ENSG00000135269 MIM:606085; AllianceGenome:HGNC:14620
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TESS; TESS-2
Summary
Cancer-associated chromosomal changes often involve regions containing fragile sites. This gene maps to a common fragile site on chromosome 7q31.2 designated FRA7G. This gene is similar to mouse Testin, a testosterone-responsive gene encoding a Sertoli cell secretory protein containing three LIM domains. LIM domains are double zinc-finger motifs that mediate protein-protein interactions between transcription factors, cytoskeletal proteins and signaling proteins. This protein is a negative regulator of cell growth and may act as a tumor suppressor. This scaffold protein may also play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Multiple protein isoforms are encoded by transcript variants of this gene.[provided by RefSeq, Aug 2023]
Expression
Ubiquitous expression in urinary bladder (RPKM 42.6), thyroid (RPKM 41.1) and 23 other tissues See more
Orthologs
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Genomic context

See TES in Genome Data Viewer
Location:
7q31.2
Exon count:
8
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (116210539..116258783)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (117525529..117573770)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (115850593..115898837)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC102724407 Neighboring gene VISTA enhancer hs1798 Neighboring gene transcription factor EC Neighboring gene Sharpr-MPRA regulatory region 6568 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr7:115807196-115807710 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:115825203-115826194 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:115826195-115827184 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26526 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18555 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:115850475-115850737 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18553 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26527 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26528 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26529 Neighboring gene uncharacterized LOC124901730 Neighboring gene uncharacterized LOC102724434 Neighboring gene uncharacterized LOC105375463 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26530 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26531 Neighboring gene Sharpr-MPRA regulatory region 1934 Neighboring gene uncharacterized LOC124900233

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC1146, DKFZp586B2022

General protein information

Preferred Names
testin
Names
testis derived transcript (3 LIM domains)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015641.4NP_056456.1  testin isoform 1

    See identical proteins and their annotated locations for NP_056456.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform.
    Source sequence(s)
    AF245356, DC341259
    Consensus CDS
    CCDS5763.1
    UniProtKB/Swiss-Prot
    A4D0U6, Q9GZQ1, Q9HAJ9, Q9UGI8
    UniProtKB/TrEMBL
    A4D0U5, B2RDR4
    Related
    ENSP00000350937.4, ENST00000358204.9
    Conserved Domains (4) summary
    cd09413
    Location:236293
    LIM1_Testin; The first LIM domain of Testin
    cd09416
    Location:299354
    LIM2_Testin; The second LIM domain of Testin
    cd09419
    Location:361419
    LIM3_Testin; The third LIM domain of Testin
    cd09829
    Location:109196
    PET_testin; The PET domain of Testin
  2. NM_152829.3NP_690042.1  testin isoform 2

    See identical proteins and their annotated locations for NP_690042.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) contains an alternate in-frame exon in the 5' UTR and uses a downstream start codon, compared to variant 1. Thus isoform 2 is nine amino acids shorter than isoform 1.
    Source sequence(s)
    AF245357, AK310995
    Consensus CDS
    CCDS5764.1
    UniProtKB/TrEMBL
    B2RDR4
    Related
    ENSP00000377121.2, ENST00000393481.6
    Conserved Domains (4) summary
    cd09413
    Location:227284
    LIM1_Testin; The first LIM domain of Testin
    cd09416
    Location:290345
    LIM2_Testin; The second LIM domain of Testin
    cd09419
    Location:352410
    LIM3_Testin; The third LIM domain of Testin
    cd09829
    Location:100187
    PET_testin; The PET domain of Testin

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

    Range
    116210539..116258783
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060931.1 Alternate T2T-CHM13v2.0

    Range
    117525529..117573770
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)