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SERBP1 SERPINE1 mRNA binding protein 1 [ Homo sapiens (human) ]

Gene ID: 26135, updated on 5-Jul-2020

Summary

Official Symbol
SERBP1provided by HGNC
Official Full Name
SERPINE1 mRNA binding protein 1provided by HGNC
Primary source
HGNC:HGNC:17860
See related
Ensembl:ENSG00000142864 MIM:607378
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CGI-55; CHD3IP; HABP4L; PAIRBP1; PAI-RBP1
Expression
Ubiquitous expression in esophagus (RPKM 40.3), thyroid (RPKM 34.9) and 25 other tissues See more
Orthologs

Genomic context

See SERBP1 in Genome Data Viewer
Location:
1p31.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (67407810..67430402, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (67873493..67896123, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene DNAJB6 pseudogene 4 Neighboring gene interleukin 12 receptor subunit beta 2 Neighboring gene uncharacterized LOC105378779 Neighboring gene RNA, U6 small nuclear 387, pseudogene Neighboring gene long intergenic non-protein coding RNA 1702 Neighboring gene RNA, U6 small nuclear 1031, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
A genome-wide scan of Ashkenazi Jewish Crohn's disease suggests novel susceptibility loci.
NHGRI GWA Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ90489, DKFZp564M2423

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
SUMO binding IDA
Inferred from Direct Assay
more info
PubMed 
cadherin binding HDA PubMed 
mRNA 3'-UTR binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mRNA 3'-UTR binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
PML body organization IDA
Inferred from Direct Assay
more info
PubMed 
regulation of apoptotic process IEA
Inferred from Electronic Annotation
more info
 
regulation of mRNA stability NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
extracellular exosome HDA PubMed 
membrane HDA PubMed 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
plasminogen activator inhibitor 1 RNA-binding protein
Names
PAI-1 mRNA binding protein
PAI1 RNA-binding protein 1
chromodomain helicase DNA binding protein 3 interacting protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001018067.2NP_001018077.1  plasminogen activator inhibitor 1 RNA-binding protein isoform 1

    See identical proteins and their annotated locations for NP_001018077.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AK074970, AL358512, AL590559, BC008045
    Consensus CDS
    CCDS30746.1
    UniProtKB/Swiss-Prot
    Q8NC51
    Related
    ENSP00000360034.2, ENST00000370995.6
    Conserved Domains (2) summary
    pfam04774
    Location:189313
    HABP4_PAI-RBP1; Hyaluronan / mRNA binding family
    pfam16174
    Location:5122
    IHABP4_N; Intracellular hyaluronan-binding protein 4 N-terminal
  2. NM_001018068.2NP_001018078.1  plasminogen activator inhibitor 1 RNA-binding protein isoform 2

    See identical proteins and their annotated locations for NP_001018078.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate, in-frame splice site in the coding region, compared to variant 1. It encodes isoform 2, which is shorter than isoform 1.
    Source sequence(s)
    AL358512, AL590559, BC020555
    Consensus CDS
    CCDS30748.1
    UniProtKB/Swiss-Prot
    Q8NC51
    Related
    ENSP00000360029.5, ENST00000370990.5
    Conserved Domains (2) summary
    pfam04774
    Location:189307
    HABP4_PAI-RBP1; Hyaluronan / mRNA binding family
    pfam16174
    Location:5122
    IHABP4_N; Intracellular hyaluronan-binding protein 4 N-terminal
  3. NM_001018069.2NP_001018079.1  plasminogen activator inhibitor 1 RNA-binding protein isoform 3

    See identical proteins and their annotated locations for NP_001018079.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) uses an alternate, in-frame splice site in the coding region, compared to variant 1. It encodes isoform 3, which is shorter than isoform 1.
    Source sequence(s)
    AF151813, AL358512, AL590559
    Consensus CDS
    CCDS30747.1
    UniProtKB/Swiss-Prot
    Q8NC51
    Related
    ENSP00000354591.6, ENST00000361219.10
    Conserved Domains (2) summary
    pfam04774
    Location:189298
    HABP4_PAI-RBP1; Hyaluronan / mRNA binding family
    pfam16174
    Location:5122
    IHABP4_N; Intracellular hyaluronan-binding protein 4 N-terminal
  4. NM_015640.4NP_056455.3  plasminogen activator inhibitor 1 RNA-binding protein isoform 4

    See identical proteins and their annotated locations for NP_056455.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) uses alternate, in-frame splice sites in the coding region, compared to variant 1. It encodes isoform 4, which is shorter than isoform 1.
    Source sequence(s)
    AK074970, AL358512, BI464676, BX647139
    Consensus CDS
    CCDS639.1
    UniProtKB/Swiss-Prot
    Q8NC51
    UniProtKB/TrEMBL
    Q5VU21, Q63HR1
    Related
    ENSP00000360033.4, ENST00000370994.8
    Conserved Domains (2) summary
    pfam04774
    Location:189292
    HABP4_PAI-RBP1; Hyaluronan / mRNA binding family
    pfam16174
    Location:5122
    IHABP4_N; Intracellular hyaluronan-binding protein 4 N-terminal

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    67407810..67430402 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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