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TRPC4AP transient receptor potential cation channel subfamily C member 4 associated protein [ Homo sapiens (human) ]

Gene ID: 26133, updated on 27-Nov-2024

Summary

Official Symbol
TRPC4APprovided by HGNC
Official Full Name
transient receptor potential cation channel subfamily C member 4 associated proteinprovided by HGNC
Primary source
HGNC:HGNC:16181
See related
Ensembl:ENSG00000100991 MIM:608430; AllianceGenome:HGNC:16181
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRUSS; TRRP4AP; PPP1R158; C20orf188
Summary
Enables phosphatase binding activity and ubiquitin-like ligase-substrate adaptor activity. Involved in protein ubiquitination and ubiquitin-dependent protein catabolic process via the C-end degron rule pathway. Part of Cul4A-RING E3 ubiquitin ligase complex. Is active in Cul4-RING E3 ubiquitin ligase complex. [provided by Alliance of Genome Resources, Nov 2024]
Expression
Ubiquitous expression in placenta (RPKM 20.6), spleen (RPKM 19.3) and 25 other tissues See more
Orthologs
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Genomic context

See TRPC4AP in Genome Data Viewer
Location:
20q11.22
Exon count:
22
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (35002404..35092807, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (36717007..36813143, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (33590207..33680610, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17770 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17771 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:33554901-33555058 Neighboring gene glutathione synthetase Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:33568001-33568552 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:33571861-33572412 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:33573515-33574066 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:33574067-33574618 Neighboring gene myosin heavy chain 7B Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:33586565-33587064 Neighboring gene microRNA 499a Neighboring gene microRNA 499b Neighboring gene MPRA-validated peak4198 silencer Neighboring gene RNA, U6 small nuclear 407, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17772 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17773 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr20:33678296-33678855 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12852 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12853 Neighboring gene MMP24-AS1-EDEM2 readthrough Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:33689161-33689662 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:33689663-33690162 Neighboring gene small nucleolar RNA SNORD56 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr20:33721175-33722374 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:33734321-33734924 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17774 Neighboring gene ER degradation enhancing alpha-mannosidase like protein 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:33761988-33762690 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:33763393-33764095 Neighboring gene protein C receptor Neighboring gene RNA, 5S ribosomal pseudogene 483

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables calcium channel activity TAS
Traceable Author Statement
more info
 
enables phosphatase binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables phosphatase binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin-like ligase-substrate adaptor activity IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
part_of Cul4-RING E3 ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of Cul4A-RING E3 ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
 
part_of Cul4A-RING E3 ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in perinuclear region of cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
short transient receptor potential channel 4-associated protein
Names
TNF-receptor ubiquitous scaffolding/signaling protein
TRP4-associated protein
protein phosphatase 1, regulatory subunit 158
trpc4-associated protein
tumor necrosis factor receptor-associated ubiquitous scaffolding and signaling protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015638.3NP_056453.1  short transient receptor potential channel 4-associated protein isoform a

    See identical proteins and their annotated locations for NP_056453.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    BC008836, BC013144, BI488542, BM149369, BM723903, CF125531
    Consensus CDS
    CCDS13246.1
    UniProtKB/Swiss-Prot
    E1P5Q0, E1P5Q1, Q8TEL6, Q96H82, Q9BVB8, Q9H429, Q9UFS6
    UniProtKB/TrEMBL
    B2RDK8
    Related
    ENSP00000252015.2, ENST00000252015.3
    Conserved Domains (1) summary
    pfam12463
    Location:407713
    DUF3689; Protein of unknown function (DUF3689)
  2. NM_199368.2NP_955400.1  short transient receptor potential channel 4-associated protein isoform b

    See identical proteins and their annotated locations for NP_955400.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1, resulting in an isoform (b) which has the same N- and C-termini but which is shorter compared to isoform a.
    Source sequence(s)
    BC008836, BC013144, BI488542, BM149369, BM723903, CF125531
    Consensus CDS
    CCDS46591.1
    UniProtKB/TrEMBL
    B2RDK8
    Related
    ENSP00000400614.1, ENST00000451813.6
    Conserved Domains (1) summary
    pfam12463
    Location:399705
    DUF3689; Protein of unknown function (DUF3689)

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

    Range
    35002404..35092807 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047440096.1XP_047296052.1  short transient receptor potential channel 4-associated protein isoform X2

  2. XM_047440095.1XP_047296051.1  short transient receptor potential channel 4-associated protein isoform X1

    UniProtKB/Swiss-Prot
    E1P5Q0, E1P5Q1, Q8TEL6, Q96H82, Q9BVB8, Q9H429, Q9UFS6
  3. XM_047440102.1XP_047296058.1  short transient receptor potential channel 4-associated protein isoform X9

    UniProtKB/TrEMBL
    B4DW48
  4. XM_047440101.1XP_047296057.1  short transient receptor potential channel 4-associated protein isoform X8

  5. XM_047440098.1XP_047296054.1  short transient receptor potential channel 4-associated protein isoform X5

  6. XM_047440097.1XP_047296053.1  short transient receptor potential channel 4-associated protein isoform X4

  7. XM_017027799.3XP_016883288.1  short transient receptor potential channel 4-associated protein isoform X3

    UniProtKB/TrEMBL
    B2RDK8
  8. XM_047440099.1XP_047296055.1  short transient receptor potential channel 4-associated protein isoform X6

  9. XM_047440100.1XP_047296056.1  short transient receptor potential channel 4-associated protein isoform X7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060944.1 Alternate T2T-CHM13v2.0

    Range
    36717007..36813143 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054323338.1XP_054179313.1  short transient receptor potential channel 4-associated protein isoform X2

  2. XM_054323337.1XP_054179312.1  short transient receptor potential channel 4-associated protein isoform X1

    UniProtKB/Swiss-Prot
    E1P5Q0, E1P5Q1, Q8TEL6, Q96H82, Q9BVB8, Q9H429, Q9UFS6
  3. XM_054323345.1XP_054179320.1  short transient receptor potential channel 4-associated protein isoform X9

    UniProtKB/TrEMBL
    B4DW48
  4. XM_054323344.1XP_054179319.1  short transient receptor potential channel 4-associated protein isoform X8

  5. XM_054323341.1XP_054179316.1  short transient receptor potential channel 4-associated protein isoform X5

  6. XM_054323340.1XP_054179315.1  short transient receptor potential channel 4-associated protein isoform X4

  7. XM_054323339.1XP_054179314.1  short transient receptor potential channel 4-associated protein isoform X3

  8. XM_054323342.1XP_054179317.1  short transient receptor potential channel 4-associated protein isoform X6

  9. XM_054323343.1XP_054179318.1  short transient receptor potential channel 4-associated protein isoform X7

RNA

  1. XR_008485250.1 RNA Sequence