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TRPC4AP transient receptor potential cation channel subfamily C member 4 associated protein [ Homo sapiens (human) ]

Gene ID: 26133, updated on 9-Feb-2020

Summary

Official Symbol
TRPC4APprovided by HGNC
Official Full Name
transient receptor potential cation channel subfamily C member 4 associated proteinprovided by HGNC
Primary source
HGNC:HGNC:16181
See related
Ensembl:ENSG00000100991 MIM:608430
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TRUSS; TRRP4AP; PPP1R158; C20orf188
Expression
Ubiquitous expression in placenta (RPKM 20.6), spleen (RPKM 19.3) and 25 other tissues See more
Orthologs

Genomic context

See TRPC4AP in Genome Data Viewer
Location:
20q11.22
Exon count:
22
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (35002404..35092835, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (33590207..33680618, complement)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene glutathione synthetase Neighboring gene uncharacterized LOC107985393 Neighboring gene myosin heavy chain 7B Neighboring gene microRNA 499a Neighboring gene microRNA 499b Neighboring gene RNA, U6 small nuclear 407, pseudogene Neighboring gene MMP24-AS1-EDEM2 readthrough Neighboring gene ER degradation enhancing alpha-mannosidase like protein 2 Neighboring gene protein C receptor Neighboring gene RNA, 5S ribosomal pseudogene 483

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

NHGRI GWAS Catalog

Description
Genetic associations for activated partial thromboplastin time and prothrombin time, their gene expression profiles, and risk of coronary artery disease.
NHGRI GWA Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
phosphatase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
phosphatase binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
calcium ion transmembrane transport TAS
Traceable Author Statement
more info
 
hair follicle maturation IEA
Inferred from Electronic Annotation
more info
 
protein ubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-dependent protein catabolic process IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
Cul4A-RING E3 ubiquitin ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Cul4A-RING E3 ubiquitin ligase complex IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
short transient receptor potential channel 4-associated protein
Names
TNF-receptor ubiquitous scaffolding/signaling protein
TRP4-associated protein
protein phosphatase 1, regulatory subunit 158
trpc4-associated protein
tumor necrosis factor receptor-associated ubiquitous scaffolding and signaling protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015638.3NP_056453.1  short transient receptor potential channel 4-associated protein isoform a

    See identical proteins and their annotated locations for NP_056453.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
    Source sequence(s)
    BC008836, BC013144, BI488542, BM149369, BM723903, CF125531
    Consensus CDS
    CCDS13246.1
    UniProtKB/Swiss-Prot
    Q8TEL6
    Related
    ENSP00000252015.2, ENST00000252015.3
    Conserved Domains (1) summary
    pfam12463
    Location:407713
    DUF3689; Protein of unknown function (DUF3689)
  2. NM_199368.1NP_955400.1  short transient receptor potential channel 4-associated protein isoform b

    See identical proteins and their annotated locations for NP_955400.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site compared to variant 1, resulting in an isoform (b) which has the same N- and C-termini but which is shorter compared to isoform a.
    Source sequence(s)
    BC008836, BC013144, BI488542, BM149369, BM723903, CF125531
    Consensus CDS
    CCDS46591.1
    UniProtKB/Swiss-Prot
    Q8TEL6
    Related
    ENSP00000400614.1, ENST00000451813.6
    Conserved Domains (1) summary
    pfam12463
    Location:399705
    DUF3689; Protein of unknown function (DUF3689)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    35002404..35092835 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017027800.2XP_016883289.1  short transient receptor potential channel 4-associated protein isoform X2

  2. XM_024451868.1XP_024307636.1  short transient receptor potential channel 4-associated protein isoform X3

    Conserved Domains (1) summary
    pfam12463
    Location:9315
    DUF3689; Protein of unknown function (DUF3689)
  3. XM_017027801.1XP_016883290.1  short transient receptor potential channel 4-associated protein isoform X3

    UniProtKB/TrEMBL
    B4DW48
    Conserved Domains (1) summary
    pfam12463
    Location:9315
    DUF3689; Protein of unknown function (DUF3689)
  4. XM_017027799.2XP_016883288.1  short transient receptor potential channel 4-associated protein isoform X1

RNA

  1. XR_001754235.2 RNA Sequence

  2. XR_936517.3 RNA Sequence

  3. XR_001754236.2 RNA Sequence

  4. XR_001754237.2 RNA Sequence

  5. XR_002958468.1 RNA Sequence

  6. XR_001754238.2 RNA Sequence

  7. XR_002958469.1 RNA Sequence

  8. XR_002958470.1 RNA Sequence

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