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LRIT1 leucine rich repeat, Ig-like and transmembrane domains 1 [ Homo sapiens (human) ]

Gene ID: 26103, updated on 22-Sep-2022

Summary

Official Symbol
LRIT1provided by HGNC
Official Full Name
leucine rich repeat, Ig-like and transmembrane domains 1provided by HGNC
Primary source
HGNC:HGNC:23404
See related
Ensembl:ENSG00000148602 MIM:616103; AllianceGenome:HGNC:23404
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PAL; LRRC21; FIGLER9
Summary
Predicted to be integral component of endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Restricted expression toward testis (RPKM 2.4) See more
Orthologs
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Genomic context

See LRIT1 in Genome Data Viewer
Location:
10q23.1
Exon count:
5
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (84231520..84241546, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (85110046..85120066, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (85991276..86001302, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene cadherin related family member 1 Neighboring gene leucine rich repeat, Ig-like and transmembrane domains 2 Neighboring gene retinal G protein coupled receptor Neighboring gene long intergenic non-protein coding RNA 858

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp434K091

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables molecular_function ND
No biological Data available
more info
 
Process Evidence Code Pubs
involved_in biological_process ND
No biological Data available
more info
 
Component Evidence Code Pubs
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in endoplasmic reticulum membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1
Names
fibronectin type III, immunoglobulin and leucine rich repeat domains 9
leucine rich repeat containing 21
leucine-rich repeat, immunoglobulin-like and transmembrane domains 1
leucine-rich repeat-containing protein 21
photoreceptor-associated LRR superfamily protein
retina-specific protein PAL

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015613.3NP_056428.1  leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1 precursor

    See identical proteins and their annotated locations for NP_056428.1

    Status: VALIDATED

    Source sequence(s)
    AB031547, AC022389
    Consensus CDS
    CCDS7373.1
    UniProtKB/Swiss-Prot
    Q9P2V4, Q9Y4N7
    Related
    ENSP00000361177.3, ENST00000372105.4
    Conserved Domains (7) summary
    smart00060
    Location:431498
    FN3; Fibronectin type 3 domain
    smart00410
    Location:267345
    IG_like; Immunoglobulin like
    sd00031
    Location:6184
    LRR_1; leucine-rich repeat [structural motif]
    pfam12799
    Location:131171
    LRR_4; Leucine Rich repeats (2 copies)
    pfam13855
    Location:131202
    LRR_8; Leucine rich repeat
    cl11960
    Location:267345
    Ig; Immunoglobulin domain
    cl15307
    Location:201240
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    Range
    84231520..84241546 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539626.3XP_011537928.1  leucine-rich repeat, immunoglobulin-like domain and transmembrane domain-containing protein 1 isoform X1

    Conserved Domains (4) summary
    smart00060
    Location:236303
    FN3; Fibronectin type 3 domain
    smart00410
    Location:72150
    IG_like; Immunoglobulin like
    cl11960
    Location:72150
    Ig; Immunoglobulin domain
    cl15307
    Location:645
    TPKR_C2; Tyrosine-protein kinase receptor C2 Ig-like domain

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060934.1 Alternate T2T-CHM13v2.0

    Range
    85110046..85120066 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)