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PTPN20 protein tyrosine phosphatase non-receptor type 20 [ Homo sapiens (human) ]

Gene ID: 26095, updated on 21-Dec-2019

Summary

Official Symbol
PTPN20provided by HGNC
Official Full Name
protein tyrosine phosphatase non-receptor type 20provided by HGNC
Primary source
HGNC:HGNC:23423
See related
Ensembl:ENSG00000204179 MIM:610630; MIM:610631
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CT126; PTPN20A; PTPN20B; bA42B19.1; bA142I17.1
Summary
The product of this gene belongs to the family of classical tyrosine-specific protein tyrosine phosphatases. Many protein tyrosine phosphatases have been shown to regulate fundamental cellular processes. The encoded protein appears to be targeted to sites of actin polymerization. A pseudogene of this gene has been defined on chromosome 10. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2014]
Expression
Broad expression in testis (RPKM 2.2), adrenal (RPKM 1.4) and 18 other tissues See more
Orthologs

Genomic context

See PTPN20 in Genome Data Viewer
Location:
10q11.22
Exon count:
17
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (46911372..47003829)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (48737042..48827942, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene FERM and PDZ domain containing 2 pseudogene Neighboring gene FERM and PDZ domain containing 2B, pseudogene Neighboring gene uncharacterized LOC105378291 Neighboring gene uncharacterized LOC101929216 Neighboring gene growth differentiation factor 10

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0187, MGC142033, DKFZp566K0524, DKFZp781P23155

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein tyrosine phosphatase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cellular response to cytokine stimulus TAS
Traceable Author Statement
more info
 
peptidyl-tyrosine dephosphorylation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
centriolar satellite IDA
Inferred from Direct Assay
more info
 
cytoplasm IEA
Inferred from Electronic Annotation
more info
 
microtubule IEA
Inferred from Electronic Annotation
more info
 
nucleoplasm TAS
Traceable Author Statement
more info
 

General protein information

Preferred Names
tyrosine-protein phosphatase non-receptor type 20
Names
protein tyrosine phosphatase, non-receptor type 20A
protein tyrosine phosphatase, non-receptor type 20B
NP_001035816.1
NP_001035817.1
NP_001035818.1
NP_001035819.1
NP_001035820.1
NP_001035821.1
NP_001035822.1
NP_001035823.1
NP_001035824.1
NP_001307610.1
NP_001307611.1
NP_001307612.1
NP_001307613.1
NP_001307614.1
NP_001307615.1
NP_001307617.1
NP_001307618.1
NP_001307619.1
NP_001307620.1
NP_001339450.1
NP_001339451.1
NP_001339452.1
NP_001339453.1
NP_001339454.1
NP_001339455.1
NP_001339456.1
NP_001339457.1
NP_001339458.1
NP_001339459.1
NP_001339460.1
NP_001339461.1
NP_001339462.1
NP_001339463.1
NP_001339464.1
NP_001339465.1
NP_001339466.1
NP_001339467.1
NP_001339468.1
NP_001339469.1
NP_001339470.1
NP_001339471.1
NP_001339472.1
NP_001339473.1
NP_001339474.1
NP_001339475.1
NP_001339476.1
NP_001339477.1
NP_001339478.1
NP_001339479.1
NP_001339480.1
NP_001339481.1
NP_001339482.1
NP_001339483.1
NP_001339484.1
NP_056420.3
XP_011537907.1
XP_011537908.1
XP_011537909.1
XP_011537912.1
XP_016871531.1
XP_016871532.1
XP_016871534.1
XP_016871535.1
XP_016871536.1
XP_016871537.1
XP_016871542.1
XP_016871544.1
XP_016871551.1
XP_016871553.1
XP_024303702.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001042357.4NP_001035816.1  tyrosine-protein phosphatase non-receptor type 20 isoform 1

    See identical proteins and their annotated locations for NP_001035816.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
    Source sequence(s)
    AL050040, AL358791, AY704146, BC036539, BC093750, BX648913
    Consensus CDS
    CCDS73110.1
    UniProtKB/Swiss-Prot
    Q4JDL3
    UniProtKB/TrEMBL
    Q9Y406
    Related
    ENSP00000363459.3, ENST00000374339.4
    Conserved Domains (2) summary
    smart00194
    Location:159411
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:185411
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  2. NM_001042358.4NP_001035817.1  tyrosine-protein phosphatase non-receptor type 20 isoform 3

    See identical proteins and their annotated locations for NP_001035817.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR and in the 5' coding region, compared to variant 1. The resulting protein (isoform 3) contains a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AL358791, AY704141, AY753191, BC036539
    Consensus CDS
    CCDS73105.1
    UniProtKB/Swiss-Prot
    Q4JDL3
    Related
    ENSP00000424283.1, ENST00000511769.5
    Conserved Domains (1) summary
    smart00194
    Location:150402
    PTPc; Protein tyrosine phosphatase, catalytic domain
  3. NM_001042359.3NP_001035818.1  tyrosine-protein phosphatase non-receptor type 20 isoform 4

    See identical proteins and their annotated locations for NP_001035818.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR and in the 5' coding region, compared to variant 1. It also lacks an in-frame segment of the coding region, compared to variant 1. The resulting protein (isoform 4) is shorter and contains a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AY704141, AY753191, BC036539
    Consensus CDS
    CCDS73107.1
    UniProtKB/Swiss-Prot
    Q4JDL3
    Related
    ENSP00000425912.1, ENST00000513156.5
    Conserved Domains (1) summary
    pfam00102
    Location:142260
    Y_phosphatase; Protein-tyrosine phosphatase
  4. NM_001042360.3NP_001035819.1  tyrosine-protein phosphatase non-receptor type 20 isoform 5

    See identical proteins and their annotated locations for NP_001035819.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR and in the 5' coding region, compared to variant 1. The resulting protein (isoform 5) contains a distinct N-terminus, compared to isoform 1.
    Source sequence(s)
    AY704141, AY753191, BC036539
    Consensus CDS
    CCDS73109.1
    UniProtKB/Swiss-Prot
    Q4JDL3
    Related
    ENSP00000379077.2, ENST00000395727.6
    Conserved Domains (1) summary
    cd00047
    Location:4219
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  5. NM_001042361.4NP_001035820.1  tyrosine-protein phosphatase non-receptor type 20 isoform 6

    See identical proteins and their annotated locations for NP_001035820.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) has multiple coding region differences, compared to variant 1, one of which results in a frameshift. The resulting protein (isoform 6) contains distinct N- and C-termini, compared to isoform 1.
    Source sequence(s)
    AL358791, AY704141, AY753191, BC036539
    Consensus CDS
    CCDS73106.1
    UniProtKB/Swiss-Prot
    Q4JDL3
    Related
    ENSP00000425362.1, ENST00000509774.5
    Conserved Domains (1) summary
    cl27757
    Location:150188
    Y_phosphatase; Protein-tyrosine phosphatase
  6. NM_001042362.3NP_001035821.1  tyrosine-protein phosphatase non-receptor type 20 isoform 7

    See identical proteins and their annotated locations for NP_001035821.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7) has multiple coding region differences, compared to variant 1, one of which results in a frameshift. The resulting protein (isoform 7) contains distinct N- and C-termini, compared to isoform 1.
    Source sequence(s)
    AY704141, AY753191, BC036539
    Consensus CDS
    CCDS73108.1
    UniProtKB/Swiss-Prot
    Q4JDL3
    Related
    ENSP00000427676.1, ENST00000503851.5
  7. NM_001042363.4NP_001035822.1  tyrosine-protein phosphatase non-receptor type 20 isoform 8

    See identical proteins and their annotated locations for NP_001035822.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start site compared to variant 1. The encoded isoform (8) has a shorter N-terminus compared to isoform 1. Variants 8, 11, and 12 all encode the same isoform (8).
    Source sequence(s)
    AL050040, AL358791, AY704141, BC036539, BX648913
    Consensus CDS
    CCDS73114.1
    UniProtKB/Swiss-Prot
    Q4JDL3
    UniProtKB/TrEMBL
    Q9Y406
    Related
    ENSP00000363335.2, ENST00000374218.6
    Conserved Domains (1) summary
    smart00194
    Location:78330
    PTPc; Protein tyrosine phosphatase, catalytic domain
  8. NM_001042364.4NP_001035823.1  tyrosine-protein phosphatase non-receptor type 20 isoform 9

    See identical proteins and their annotated locations for NP_001035823.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9) differs in the 5' UTR and has multiple coding region differences, compared to variant 1, one of which results in a frameshift. These differences cause translation initiation at a downstream AUG and a protein (isoform 9) with a distinct C-terminus, compared to isoform 1. Variants 9, 32, and 33 all encode the same isoform (9).
    Source sequence(s)
    AL050040, AL358791, BC036539, BX648913
    Consensus CDS
    CCDS73115.1
    UniProtKB/Swiss-Prot
    Q4JDL3
    UniProtKB/TrEMBL
    Q9Y406
    Related
    ENSP00000379075.3, ENST00000395725.7
    Conserved Domains (1) summary
    cl27757
    Location:78116
    Y_phosphatase; Protein-tyrosine phosphatase
  9. NM_001042365.3NP_001035824.1  tyrosine-protein phosphatase non-receptor type 20 isoform 10

    See identical proteins and their annotated locations for NP_001035824.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR and has multiple coding region differences, compared to variant 1, one of which results in a frameshift. These differences cause translation initiation at a downstream AUG and a protein (isoform 10) with a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL050040, BC036539, BX648913
    Consensus CDS
    CCDS73116.1
    UniProtKB/TrEMBL
    Q4JDK3, Q9Y406
    Related
    ENSP00000363462.3, ENST00000374342.6
  10. NM_001320681.1NP_001307610.1  tyrosine-protein phosphatase non-receptor type 20 isoform 8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start site compared to variant 1. The encoded isoform (8) has a shorter N-terminus compared to isoform 1. Variants 8, 11, and 12 all encode the same isoform (8).
    Source sequence(s)
    AL050040, AL358791, AY704141, BC036539, BX648913
    Consensus CDS
    CCDS73114.1
    UniProtKB/Swiss-Prot
    Q4JDL3
    UniProtKB/TrEMBL
    Q9Y406
    Related
    ENSP00000379071.2, ENST00000395721.6
    Conserved Domains (1) summary
    smart00194
    Location:78330
    PTPc; Protein tyrosine phosphatase, catalytic domain
  11. NM_001320682.1NP_001307611.1  tyrosine-protein phosphatase non-receptor type 20 isoform 11

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13) differs in the 5' UTR and lacks portions of the 5' and 3' coding regions, resulting in a frameshift compared to variant 1. The encoded isoform (11) is shorter than isoform 1. Variants 13-15, 47, and 48 all encode the same isoform (11).
    Source sequence(s)
    BC036539, BC143394, BX648913, CR933668
    UniProtKB/Swiss-Prot
    Q4JDL3
    UniProtKB/TrEMBL
    Q5H9Q9
    Conserved Domains (1) summary
    cl27757
    Location:5183
    Y_phosphatase; Protein-tyrosine phosphatase
  12. NM_001320683.1NP_001307612.1  tyrosine-protein phosphatase non-receptor type 20 isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17) differs in the 5' UTR and lacks two alternate exons in the coding region, resulting in a frameshift compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1. Both variants 2 and 17 encode the same isoform (2).
    Source sequence(s)
    AL358791, AY704147, AY753191, BC036539, BC093750
    Consensus CDS
    CCDS73111.1
    UniProtKB/Swiss-Prot
    Q4JDL3
    Related
    ENSP00000425012.1, ENST00000509599.5
    Conserved Domains (1) summary
    smart00194
    Location:159197
    PTPc; Protein tyrosine phosphatase, catalytic domain
  13. NM_001320684.1NP_001307613.1  tyrosine-protein phosphatase non-receptor type 20 isoform 13

    Status: REVIEWED

    Description
    Transcript Variant: This variant (18) differs in the 5' UTR and lacks three alternate in-frame exons in the coding region compared to variant 1. The encoded isoform (13) is shorter than isoform 1.
    Source sequence(s)
    AY704148, AY753191, BC036539, BC143394
    Consensus CDS
    CCDS81454.1
    UniProtKB/Swiss-Prot
    Q4JDL3
    Related
    ENSP00000420995.1, ENST00000502705.5
    Conserved Domains (1) summary
    cl21483
    Location:158197
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  14. NM_001320685.1NP_001307614.1  tyrosine-protein phosphatase non-receptor type 20 isoform 14

    Status: REVIEWED

    Description
    Transcript Variant: This variant (19) differs in the 5' UTR and lacks one alternate exon in the 5' coding region, resulting in a frameshift compared to variant 1. The encoded isoform (14) is shorter and has a distinct N-terminus compared to isoform 1. Variants 19 and 21 both encode the same isoform (14).
    Source sequence(s)
    AL358791, AY704150, AY753191, BC036539, BX005072
    UniProtKB/Swiss-Prot
    Q4JDL3
    Conserved Domains (1) summary
    smart00194
    Location:131383
    PTPc; Protein tyrosine phosphatase, catalytic domain
  15. NM_001320686.1NP_001307615.1  tyrosine-protein phosphatase non-receptor type 20 isoform 8

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start site compared to variant 1. The encoded isoform (8) has a shorter N-terminus compared to isoform 1. Variants 8, 11, and 12 all encode the same isoform (8).
    Source sequence(s)
    AL358791, AY704152, AY753191, BC036539
    Consensus CDS
    CCDS73114.1
    UniProtKB/Swiss-Prot
    Q4JDL3
    Related
    ENSP00000426355.1, ENST00000505814.5
    Conserved Domains (1) summary
    smart00194
    Location:78330
    PTPc; Protein tyrosine phosphatase, catalytic domain
  16. NM_001320688.1NP_001307617.1  tyrosine-protein phosphatase non-receptor type 20 isoform 15

    Status: REVIEWED

    Description
    Transcript Variant: This variant (20) differs in the 5' UTR and has multiple coding region differences compared to variant 1. The encoded isoform (15) is shorter than isoform 1.
    Source sequence(s)
    AY704153, AY753191, BC036539
    Consensus CDS
    CCDS81456.1
    UniProtKB/Swiss-Prot
    Q4JDL3
    Related
    ENSP00000422839.1, ENST00000513266.5
    Conserved Domains (1) summary
    pfam00102
    Location:70188
    Y_phosphatase; Protein-tyrosine phosphatase
  17. NM_001320689.1NP_001307618.1  tyrosine-protein phosphatase non-receptor type 20 isoform 11

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14) differs in the 5' UTR and lacks portions of the 5' and 3' coding regions, resulting in a frameshift compared to variant 1. The encoded isoform (11) is shorter than isoform 1. Variants 13-15, 47, and 48 all encode the same isoform (11).
    Source sequence(s)
    AY704156, AY753191, BC036539
    UniProtKB/Swiss-Prot
    Q4JDL3
    UniProtKB/TrEMBL
    Q4JDK3
    Conserved Domains (1) summary
    cl27757
    Location:5183
    Y_phosphatase; Protein-tyrosine phosphatase
  18. NM_001320690.1NP_001307619.1  tyrosine-protein phosphatase non-receptor type 20 isoform 11

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15) differs in the 5' UTR and lacks portions of the 5' and 3' coding regions, resulting in a frameshift compared to variant 1. The encoded isoform (11) is shorter than isoform 1. Variants 13-15, 47, and 48 all encode the same isoform (11).
    Source sequence(s)
    AY704157, AY753191, BC036539
    UniProtKB/Swiss-Prot
    Q4JDL3
    UniProtKB/TrEMBL
    Q4JDK3
    Conserved Domains (1) summary
    cl27757
    Location:5183
    Y_phosphatase; Protein-tyrosine phosphatase
  19. NM_001320691.1NP_001307620.1  tyrosine-protein phosphatase non-receptor type 20 isoform 12

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16) differs in the 5' UTR, lacks a portion of the coding region and initiates translation at a downstream start site compared to variant 1. The encoded isoform (12) has a shorter N-terminus compared to isoform 1. Variants 16 and 25-30 all encode the same isoform (12).
    Source sequence(s)
    AY704158, AY753191, BC036539
    UniProtKB/Swiss-Prot
    Q4JDL3
    Conserved Domains (1) summary
    cd00047
    Location:1170
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  20. NM_001352521.1NP_001339450.1  tyrosine-protein phosphatase non-receptor type 20 isoform 14

    Status: REVIEWED

    Description
    Transcript Variant: This variant (21), as well as variant 19, encodes isoform 14.
    Source sequence(s)
    AL358791, BX005072
    Conserved Domains (1) summary
    smart00194
    Location:131383
    PTPc; Protein tyrosine phosphatase, catalytic domain
  21. NM_001352522.1NP_001339451.1  tyrosine-protein phosphatase non-receptor type 20 isoform 16

    Status: REVIEWED

    Source sequence(s)
    AL358791, BX005072
    Conserved Domains (1) summary
    smart00194
    Location:78258
    PTPc; Protein tyrosine phosphatase, catalytic domain
  22. NM_001352523.1NP_001339452.1  tyrosine-protein phosphatase non-receptor type 20 isoform 17

    Status: REVIEWED

    Source sequence(s)
    AL358791, BX005072
    Conserved Domains (1) summary
    cl27757
    Location:131169
    Y_phosphatase; Protein-tyrosine phosphatase
  23. NM_001352524.1NP_001339453.1  tyrosine-protein phosphatase non-receptor type 20 isoform 30

    Status: REVIEWED

    Source sequence(s)
    AL358791, BX005072
    Conserved Domains (1) summary
    cl27757
    Location:150188
    Y_phosphatase; Protein-tyrosine phosphatase
  24. NM_001352525.1NP_001339454.1  tyrosine-protein phosphatase non-receptor type 20 isoform 12

    Status: REVIEWED

    Description
    Transcript Variant: This variant (25), as well as variants 16 and 26-30, encodes isoform 12.
    Source sequence(s)
    AL358791, BX005072
    Conserved Domains (1) summary
    cd00047
    Location:1170
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  25. NM_001352526.1NP_001339455.1  tyrosine-protein phosphatase non-receptor type 20 isoform 12

    Status: REVIEWED

    Description
    Transcript Variant: This variant (26), as well as variants 16, 25, and 27-30, encodes isoform 12.
    Source sequence(s)
    AL358791, BX005072
    Conserved Domains (1) summary
    cd00047
    Location:1170
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  26. NM_001352527.1NP_001339456.1  tyrosine-protein phosphatase non-receptor type 20 isoform 12

    Status: REVIEWED

    Description
    Transcript Variant: This variant (27), as well as variants 16, 25, 26, and 28-30, encodes isoform 12.
    Source sequence(s)
    AL358791, BX005072
    Conserved Domains (1) summary
    cd00047
    Location:1170
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  27. NM_001352528.1NP_001339457.1  tyrosine-protein phosphatase non-receptor type 20 isoform 12

    Status: REVIEWED

    Description
    Transcript Variant: This variant (28), as well as variants 16, 25-27, 29, and 30, encodes isoform 12.
    Source sequence(s)
    AL358791, BX005072
    Conserved Domains (1) summary
    cd00047
    Location:1170
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  28. NM_001352529.1NP_001339458.1  tyrosine-protein phosphatase non-receptor type 20 isoform 12

    Status: REVIEWED

    Description
    Transcript Variant: This variant (29), as well as variants 16, 25-28, and 30, encodes isoform 12.
    Source sequence(s)
    AL358791, BX005072
    Conserved Domains (1) summary
    cd00047
    Location:1170
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  29. NM_001352530.1NP_001339459.1  tyrosine-protein phosphatase non-receptor type 20 isoform 12

    Status: REVIEWED

    Description
    Transcript Variant: This variant (30), as well as variants 16 and 25-29, encodes isoform 12.
    Source sequence(s)
    AL358791, BX005072
    Conserved Domains (1) summary
    cd00047
    Location:1170
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  30. NM_001352531.1NP_001339460.1  tyrosine-protein phosphatase non-receptor type 20 isoform 31

    Status: REVIEWED

    Source sequence(s)
    AL358791, BX005072
    Consensus CDS
    CCDS86087.1
    Related
    ENSP00000421404.1, ENST00000502254.5
  31. NM_001352532.1NP_001339461.1  tyrosine-protein phosphatase non-receptor type 20 isoform 9

    Status: REVIEWED

    Description
    Transcript Variant: This variant (32), as well as variants 9 and 33, encodes isoform 9.
    Source sequence(s)
    AL358791, BX005072
    Consensus CDS
    CCDS73115.1
    Conserved Domains (1) summary
    cl27757
    Location:78116
    Y_phosphatase; Protein-tyrosine phosphatase
  32. NM_001352533.1NP_001339462.1  tyrosine-protein phosphatase non-receptor type 20 isoform 9

    Status: REVIEWED

    Description
    Transcript Variant: This variant (33), as well as variants 9 and 32, encodes isoform 9.
    Source sequence(s)
    AL358791, BX005072
    Consensus CDS
    CCDS73115.1
    Related
    ENSP00000423819.1, ENST00000509900.5
    Conserved Domains (1) summary
    cl27757
    Location:78116
    Y_phosphatase; Protein-tyrosine phosphatase
  33. NM_001352534.1NP_001339463.1  tyrosine-protein phosphatase non-receptor type 20 isoform 18

    Status: REVIEWED

    Source sequence(s)
    AL358791, BX005072
    Conserved Domains (1) summary
    cl27757
    Location:131169
    Y_phosphatase; Protein-tyrosine phosphatase
  34. NM_001352535.2NP_001339464.1  tyrosine-protein phosphatase non-receptor type 20 isoform 19

    Status: REVIEWED

    Source sequence(s)
    AL358791, BX005072
  35. NM_001352536.1NP_001339465.1  tyrosine-protein phosphatase non-receptor type 20 isoform 20

    Status: REVIEWED

    Description
    Transcript Variant: This variant (36), as well as variants 37-39, encodes isoform 20.
    Source sequence(s)
    AL358791, BX005072
    Conserved Domains (1) summary
    cl27757
    Location:78116
    Y_phosphatase; Protein-tyrosine phosphatase
  36. NM_001352537.1NP_001339466.1  tyrosine-protein phosphatase non-receptor type 20 isoform 20

    Status: REVIEWED

    Description
    Transcript Variant: This variant (37), as well as variants 36, 38, and 39, encodes isoform 20.
    Source sequence(s)
    AL358791, BX005072
    Conserved Domains (1) summary
    cl27757
    Location:78116
    Y_phosphatase; Protein-tyrosine phosphatase
  37. NM_001352538.1NP_001339467.1  tyrosine-protein phosphatase non-receptor type 20 isoform 20

    Status: REVIEWED

    Description
    Transcript Variant: This variant (38), as well as variants 36, 37, and 39, encodes isoform 20.
    Source sequence(s)
    AL358791, BX005072
    Conserved Domains (1) summary
    cl27757
    Location:78116
    Y_phosphatase; Protein-tyrosine phosphatase
  38. NM_001352539.1NP_001339468.1  tyrosine-protein phosphatase non-receptor type 20 isoform 20

    Status: REVIEWED

    Description
    Transcript Variant: This variant (39), as well as variants 36-38, encodes isoform 20.
    Source sequence(s)
    AL358791, BX005072
    Conserved Domains (1) summary
    cl27757
    Location:78116
    Y_phosphatase; Protein-tyrosine phosphatase
  39. NM_001352540.2NP_001339469.1  tyrosine-protein phosphatase non-receptor type 20 isoform 29

    Status: REVIEWED

    Source sequence(s)
    AL358791, BX005072
    Conserved Domains (1) summary
    cl27757
    Location:78105
    Y_phosphatase; Protein-tyrosine phosphatase
  40. NM_001352541.1NP_001339470.1  tyrosine-protein phosphatase non-receptor type 20 isoform 21

    Status: REVIEWED

    Description
    Transcript Variant: This variant (41), as well as variant 42, encodes isoform 21.
    Source sequence(s)
    AL358791, BX005072
  41. NM_001352542.1NP_001339471.1  tyrosine-protein phosphatase non-receptor type 20 isoform 21

    Status: REVIEWED

    Description
    Transcript Variant: This variant (42), as well as variant 41, encodes isoform 21.
    Source sequence(s)
    AL358791, BX005072
  42. NM_001352543.1NP_001339472.1  tyrosine-protein phosphatase non-receptor type 20 isoform 22

    Status: REVIEWED

    Description
    Transcript Variant: This variant (43), as well as variant 44, encodes isoform 22.
    Source sequence(s)
    AL358791, BX005072
    Conserved Domains (1) summary
    cl27757
    Location:198
    Y_phosphatase; Protein-tyrosine phosphatase
  43. NM_001352544.1NP_001339473.1  tyrosine-protein phosphatase non-receptor type 20 isoform 22

    Status: REVIEWED

    Description
    Transcript Variant: This variant (44), as well as variant 43, encodes isoform 22.
    Source sequence(s)
    AL358791, BX005072
    Conserved Domains (1) summary
    cl27757
    Location:198
    Y_phosphatase; Protein-tyrosine phosphatase
  44. NM_001352545.1NP_001339474.1  tyrosine-protein phosphatase non-receptor type 20 isoform 23

    Status: REVIEWED

    Source sequence(s)
    AL358791, BX005072
    Conserved Domains (1) summary
    cl27757
    Location:5795
    Y_phosphatase; Protein-tyrosine phosphatase
  45. NM_001352546.1NP_001339475.1  tyrosine-protein phosphatase non-receptor type 20 isoform 24

    Status: REVIEWED

    Source sequence(s)
    AL358791, BX005072
    Conserved Domains (1) summary
    cl27757
    Location:4886
    Y_phosphatase; Protein-tyrosine phosphatase
  46. NM_001352547.1NP_001339476.1  tyrosine-protein phosphatase non-receptor type 20 isoform 11

    Status: REVIEWED

    Description
    Transcript Variant: This variant (47), as well as variants 13-15 and 48, encodes isoform 11.
    Source sequence(s)
    AL358791, BX005072
    Conserved Domains (1) summary
    cl27757
    Location:5183
    Y_phosphatase; Protein-tyrosine phosphatase
  47. NM_001352548.1NP_001339477.1  tyrosine-protein phosphatase non-receptor type 20 isoform 11

    Status: REVIEWED

    Description
    Transcript Variant: This variant (48), as well as variants 13-15 and 47, encodes isoform 11.
    Source sequence(s)
    AL358791, BX005072
    Conserved Domains (1) summary
    cl27757
    Location:5183
    Y_phosphatase; Protein-tyrosine phosphatase
  48. NM_001352549.2NP_001339478.1  tyrosine-protein phosphatase non-receptor type 20 isoform 25

    Status: REVIEWED

    Description
    Transcript Variant: This variant (49), as well as variant 50, encodes isoform 25.
    Source sequence(s)
    AL358791, BX005072
    Conserved Domains (1) summary
    cl27757
    Location:5172
    Y_phosphatase; Protein-tyrosine phosphatase
  49. NM_001352550.1NP_001339479.1  tyrosine-protein phosphatase non-receptor type 20 isoform 25

    Status: REVIEWED

    Description
    Transcript Variant: This variant (50), as well as variant 49, encodes isoform 25.
    Source sequence(s)
    AL358791, BX005072
    Conserved Domains (1) summary
    cl27757
    Location:5172
    Y_phosphatase; Protein-tyrosine phosphatase
  50. NM_001352551.1NP_001339480.1  tyrosine-protein phosphatase non-receptor type 20 isoform 26

    Status: REVIEWED

    Source sequence(s)
    AL358791, BX005072
    Conserved Domains (1) summary
    cl27757
    Location:4173
    Y_phosphatase; Protein-tyrosine phosphatase
  51. NM_001352552.1NP_001339481.1  tyrosine-protein phosphatase non-receptor type 20 isoform 27

    Status: REVIEWED

    Description
    Transcript Variant: This variant (52), as well as variants 53 and 54, encodes isoform 27.
    Source sequence(s)
    AL358791, BX005072
    Conserved Domains (1) summary
    cl21483
    Location:163
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  52. NM_001352553.1NP_001339482.1  tyrosine-protein phosphatase non-receptor type 20 isoform 27

    Status: REVIEWED

    Description
    Transcript Variant: This variant (53), as well as variants 52 and 54, encodes isoform 27.
    Source sequence(s)
    AL358791, BX005072
    Conserved Domains (1) summary
    cl21483
    Location:163
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  53. NM_001352554.1NP_001339483.1  tyrosine-protein phosphatase non-receptor type 20 isoform 27

    Status: REVIEWED

    Description
    Transcript Variant: This variant (54), as well as variants 52 and 53, encodes isoform 27.
    Source sequence(s)
    AL358791, BX005072
    Conserved Domains (1) summary
    cl21483
    Location:163
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  54. NM_001352555.2NP_001339484.1  tyrosine-protein phosphatase non-receptor type 20 isoform 28

    Status: REVIEWED

    Source sequence(s)
    AL358791, BX005072
  55. NM_015605.8NP_056420.3  tyrosine-protein phosphatase non-receptor type 20 isoform 2

    See identical proteins and their annotated locations for NP_056420.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and lacks two alternate exons in the coding region, resulting in a frameshift compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus compared to isoform 1. Both variants 2 and 17 encode the same isoform (2).
    Source sequence(s)
    AL050040, AL358791, AY704146, BC036539, BC093750, BX648913
    Consensus CDS
    CCDS73111.1
    UniProtKB/Swiss-Prot
    Q4JDL3
    UniProtKB/TrEMBL
    Q9Y406
    Related
    ENSP00000363466.3, ENST00000374346.7
    Conserved Domains (1) summary
    smart00194
    Location:159197
    PTPc; Protein tyrosine phosphatase, catalytic domain

RNA

  1. NR_148022.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358791, BX005072
  2. NR_148023.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358791, BX005072
  3. NR_148024.1 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AL358791, BX005072

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    46911372..47003829
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017016064.1XP_016871553.1  tyrosine-protein phosphatase non-receptor type 20 isoform X13

    UniProtKB/TrEMBL
    Q4JDK3
    Related
    ENSP00000379072.4, ENST00000395722.7
  2. XM_024447934.1XP_024303702.1  tyrosine-protein phosphatase non-receptor type 20 isoform X9

    Conserved Domains (1) summary
    smart00194
    Location:2252
    PTPc; Protein tyrosine phosphatase, catalytic domain
  3. XM_017016048.1XP_016871537.1  tyrosine-protein phosphatase non-receptor type 20 isoform X8

  4. XM_017016043.1XP_016871532.1  tyrosine-protein phosphatase non-receptor type 20 isoform X3

  5. XM_017016042.1XP_016871531.1  tyrosine-protein phosphatase non-receptor type 20 isoform X2

  6. XM_017016046.1XP_016871535.1  tyrosine-protein phosphatase non-receptor type 20 isoform X5

  7. XM_017016055.1XP_016871544.1  tyrosine-protein phosphatase non-receptor type 20 isoform X11

  8. XM_017016053.1XP_016871542.1  tyrosine-protein phosphatase non-receptor type 20 isoform X10

    UniProtKB/Swiss-Prot
    Q4JDL3
    Conserved Domains (1) summary
    cl21483
    Location:158197
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  9. XM_017016047.1XP_016871536.1  tyrosine-protein phosphatase non-receptor type 20 isoform X6

  10. XM_011539610.2XP_011537912.1  tyrosine-protein phosphatase non-receptor type 20 isoform X7

    See identical proteins and their annotated locations for XP_011537912.1

    UniProtKB/Swiss-Prot
    Q4JDL3
    Conserved Domains (1) summary
    smart00194
    Location:78330
    PTPc; Protein tyrosine phosphatase, catalytic domain
  11. XM_011539605.2XP_011537907.1  tyrosine-protein phosphatase non-receptor type 20 isoform X1

    See identical proteins and their annotated locations for XP_011537907.1

    UniProtKB/Swiss-Prot
    Q4JDL3
    Conserved Domains (2) summary
    smart00194
    Location:159411
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:185411
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  12. XM_017016062.1XP_016871551.1  tyrosine-protein phosphatase non-receptor type 20 isoform X12

  13. XM_011539607.2XP_011537909.1  tyrosine-protein phosphatase non-receptor type 20 isoform X1

    See identical proteins and their annotated locations for XP_011537909.1

    UniProtKB/Swiss-Prot
    Q4JDL3
    Conserved Domains (2) summary
    smart00194
    Location:159411
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:185411
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  14. XM_011539606.3XP_011537908.1  tyrosine-protein phosphatase non-receptor type 20 isoform X1

    See identical proteins and their annotated locations for XP_011537908.1

    UniProtKB/Swiss-Prot
    Q4JDL3
    Conserved Domains (2) summary
    smart00194
    Location:159411
    PTPc; Protein tyrosine phosphatase, catalytic domain
    cd00047
    Location:185411
    PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
  15. XM_017016045.1XP_016871534.1  tyrosine-protein phosphatase non-receptor type 20 isoform X4

RNA

  1. XR_001747082.1 RNA Sequence

  2. XR_001747083.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_001042387.1: Suppressed sequence

    Description
    NM_001042387.1: This RefSeq was permanently suppressed because it is a redundant RefSeq for this protein tyrosine phosphatase family member.
  2. NM_001042389.1: Suppressed sequence

    Description
    NM_001042389.1: This RefSeq was permanently suppressed because it is a redundant RefSeq for this protein tyrosine phosphatase family member.
  3. NM_001042390.1: Suppressed sequence

    Description
    NM_001042390.1: This RefSeq was permanently suppressed because it is a redundant RefSeq for this protein tyrosine phosphatase family member.
  4. NM_001042391.1: Suppressed sequence

    Description
    NM_001042391.1: This RefSeq was permanently suppressed because it is a redundant RefSeq for this protein tyrosine phosphatase family member.
  5. NM_001042392.1: Suppressed sequence

    Description
    NM_001042392.1: This RefSeq was permanently suppressed because it is a redundant RefSeq for this protein tyrosine phosphatase family member.
  6. NM_001042393.1: Suppressed sequence

    Description
    NM_001042393.1: This RefSeq was permanently suppressed because it is a redundant RefSeq for this protein tyrosine phosphatase family member.
  7. NM_001042394.1: Suppressed sequence

    Description
    NM_001042394.1: This RefSeq was permanently suppressed because it is a redundant RefSeq for this protein tyrosine phosphatase family member.
  8. NM_001042395.1: Suppressed sequence

    Description
    NM_001042395.1: This RefSeq was permanently suppressed because it is a redundant RefSeq for this protein tyrosine phosphatase family member.
  9. NM_001042396.1: Suppressed sequence

    Description
    NM_001042396.1: This RefSeq was permanently suppressed because it is a redundant RefSeq for this protein tyrosine phosphatase family member.
  10. NM_001042397.1: Suppressed sequence

    Description
    NM_001042397.1: This RefSeq was permanently suppressed because it is a redundant RefSeq for this protein tyrosine phosphatase family member.
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