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GPSM1 G protein signaling modulator 1 [ Homo sapiens (human) ]

Gene ID: 26086, updated on 7-Jun-2020

Summary

Official Symbol
GPSM1provided by HGNC
Official Full Name
G protein signaling modulator 1provided by HGNC
Primary source
HGNC:HGNC:17858
See related
Ensembl:ENSG00000160360 MIM:609491
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
AGS3
Summary
G-protein signaling modulators (GPSMs) play diverse functional roles through their interaction with G-protein subunits. This gene encodes a receptor-independent activator of G protein signaling, which is one of several factors that influence the basal activity of G-protein signaling systems. The protein contains seven tetratricopeptide repeats in its N-terminal half and four G-protein regulatory (GPR) motifs in its C-terminal half. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]
Expression
Broad expression in brain (RPKM 5.1), testis (RPKM 4.7) and 24 other tissues See more
Orthologs

Genomic context

See GPSM1 in Genome Data Viewer
Location:
9q34.3
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 9 NC_000009.12 (136327539..136359605)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (139221932..139254057)

Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene 9q34.3 QSOX2 distal recombination region Neighboring gene coiled-coil domain containing 187 Neighboring gene uncharacterized LOC26102 Neighboring gene Sharpr-MPRA regulatory region 3996 Neighboring gene DNL-type zinc finger Neighboring gene caspase recruitment domain family member 9 Neighboring gene small nuclear RNA activating complex polypeptide 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp727I051

Gene Ontology Provided by GOA

Function Evidence Code Pubs
GDP-dissociation inhibitor activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of GTPase activity IDA
Inferred from Direct Assay
more info
PubMed 
negative regulation of guanyl-nucleotide exchange factor activity IDA
Inferred from Direct Assay
more info
PubMed 
nervous system development IEA
Inferred from Electronic Annotation
more info
 
positive regulation of macroautophagy IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
colocalizes_with Golgi membrane IDA
Inferred from Direct Assay
more info
PubMed 
colocalizes_with cell cortex IDA
Inferred from Direct Assay
more info
PubMed 
cytosol IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
protein-containing complex IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
G-protein-signaling modulator 1
Names
G-protein signalling modulator 1 (AGS3-like, C. elegans)
activator of G-protein signaling 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_028088.2 RefSeqGene

    Range
    4996..37058
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001145638.3NP_001139110.2  G-protein-signaling modulator 1 isoform a

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (a, also known as AGS3-FL).
    Source sequence(s)
    AY173053, BC009979, BC017257, BQ214873
    Consensus CDS
    CCDS48055.1
    UniProtKB/Swiss-Prot
    Q86YR5
    UniProtKB/TrEMBL
    A0A0A0MSK4
    Related
    ENSP00000392828.1, ENST00000440944.6
    Conserved Domains (6) summary
    smart00390
    Location:596618
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    sd00006
    Location:250277
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:250278
    TPR_1; Tetratricopeptide repeat
    pfam02188
    Location:496517
    GoLoco; GoLoco motif
    pfam13176
    Location:291325
    TPR_7; Tetratricopeptide repeat
    pfam13424
    Location:210281
    TPR_12; Tetratricopeptide repeat
  2. NM_001145639.1NP_001139111.1  G-protein-signaling modulator 1 isoform c

    See identical proteins and their annotated locations for NP_001139111.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR, lacks multiple 5' coding exons, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c, also known as AGS3-SHORT) is shorter at the N-terminus, compared to isoform a. Both variants 3 and 4 encode the same isoform (c).
    Source sequence(s)
    AY173053, BC017257, BI766024, BQ214873, BU631041, BX649589
    Consensus CDS
    CCDS48056.1
    UniProtKB/Swiss-Prot
    Q86YR5
    Related
    ENSP00000390705.1, ENST00000429455.5
    Conserved Domains (1) summary
    pfam02188
    Location:122143
    GoLoco; GoLoco motif
  3. NM_001200003.2NP_001186932.1  G-protein-signaling modulator 1 isoform c

    See identical proteins and their annotated locations for NP_001186932.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR, lacks multiple 5' coding exons, and initiates translation at a downstream in-frame start codon, compared to variant 1. The encoded isoform (c, also known as AGS3-SHORT) is shorter at the N-terminus, compared to isoform a. Both variants 3 and 4 encode the same isoform (c).
    Source sequence(s)
    AL545250, AY173053, BC017257, BC048343, BX649589
    Consensus CDS
    CCDS48056.1
    UniProtKB/Swiss-Prot
    Q86YR5
    Related
    ENSP00000376673.1, ENST00000392944.5
    Conserved Domains (1) summary
    pfam02188
    Location:122143
    GoLoco; GoLoco motif
  4. NM_015597.6NP_056412.5  G-protein-signaling modulator 1 isoform b

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks multiple 3' exons and its transcription extends past a splice site used in variant 1, resulting in a distinct 3' coding region and 3' UTR. The encoded isoform (b) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AC174065, BC009979
    Consensus CDS
    CCDS6996.2
    UniProtKB/Swiss-Prot
    Q86YR5
    UniProtKB/TrEMBL
    A0A087WVF5
    Related
    ENSP00000479405.1, ENST00000616132.4
    Conserved Domains (5) summary
    sd00006
    Location:250277
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:250278
    TPR_1; Tetratricopeptide repeat
    pfam13176
    Location:291325
    TPR_7; Tetratricopeptide repeat
    pfam13424
    Location:210281
    TPR_12; Tetratricopeptide repeat
    cl14649
    Location:73160
    BRO1_Alix_like; Protein-interacting Bro1-like domain of mammalian Alix and related domains

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000009.12 Reference GRCh38.p13 Primary Assembly

    Range
    136327539..136359605
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011518498.2XP_011516800.1  G-protein-signaling modulator 1 isoform X2

    UniProtKB/TrEMBL
    A0A0A0MRC4
    Related
    ENSP00000346797.4, ENST00000354753.7
    Conserved Domains (7) summary
    smart00390
    Location:628650
    GoLoco; LGN motif, putative GEFs specific for G-alpha GTPases
    sd00006
    Location:282309
    TPR; TPR repeat [structural motif]
    pfam00515
    Location:282310
    TPR_1; Tetratricopeptide repeat
    pfam02188
    Location:528549
    GoLoco; GoLoco motif
    pfam13176
    Location:323357
    TPR_7; Tetratricopeptide repeat
    pfam13424
    Location:242313
    TPR_12; Tetratricopeptide repeat
    cl14649
    Location:105192
    BRO1_Alix_like; Protein-interacting Bro1-like domain of mammalian Alix and related domains
  2. XM_017014598.2XP_016870087.1  G-protein-signaling modulator 1 isoform X1

  3. XM_024447499.1XP_024303267.1  G-protein-signaling modulator 1 isoform X3

    Conserved Domains (1) summary
    pfam02188
    Location:122143
    GoLoco; GoLoco motif
  4. XM_017014599.2XP_016870088.1  G-protein-signaling modulator 1 isoform X3

    UniProtKB/Swiss-Prot
    Q86YR5
    Conserved Domains (1) summary
    pfam02188
    Location:122143
    GoLoco; GoLoco motif
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