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KLK13 kallikrein related peptidase 13 [ Homo sapiens (human) ]

Gene ID: 26085, updated on 21-Dec-2019

Summary

Official Symbol
KLK13provided by HGNC
Official Full Name
kallikrein related peptidase 13provided by HGNC
Primary source
HGNC:HGNC:6361
See related
Ensembl:ENSG00000167759 MIM:605505
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
KLKL4; KLK-L4
Summary
Kallikreins are a subgroup of serine proteases having diverse physiological functions. Growing evidence suggests that many kallikreins are implicated in carcinogenesis and some have potential as novel cancer and other disease biomarkers. This gene is one of the fifteen kallikrein subfamily members located in a cluster on chromosome 19. Expression of this gene is regulated by steroid hormones and may be useful as a marker for breast cancer. [provided by RefSeq, Jan 2017]
Expression
Restricted expression toward esophagus (RPKM 227.0) See more
Orthologs

Genomic context

See KLK13 in Genome Data Viewer
Location:
19q13.41
Exon count:
7
Annotation release Status Assembly Chr Location
109.20191205 current GRCh38.p13 (GCF_000001405.39) 19 NC_000019.10 (51055626..51065106, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (51559021..51568367, complement)

Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene kallikrein related peptidase 11 Neighboring gene kallikrein related peptidase 12 Neighboring gene uncharacterized LOC107985341 Neighboring gene kallikrein related peptidase 14

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp586J1923

Gene Ontology Provided by GOA

Function Evidence Code Pubs
hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
serine-type endopeptidase activity NAS
Non-traceable Author Statement
more info
PubMed 
Process Evidence Code Pubs
cornification TAS
Traceable Author Statement
more info
 
protein processing IEA
Inferred from Electronic Annotation
more info
 
proteolysis NAS
Non-traceable Author Statement
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
extracellular region TAS
Traceable Author Statement
more info
PubMed 
extracellular space IEA
Inferred from Electronic Annotation
more info
 
secretory granule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
kallikrein-13
Names
kallikrein-like gene 4
kallikrein-like protein 4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001348177.2NP_001335106.1  kallikrein-13 isoform 2 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AB108824, AC011473, AY923171
    Consensus CDS
    CCDS86795.1
    UniProtKB/TrEMBL
    Q5BQ99, Q86VI7
    Related
    ENSP00000470245.1, ENST00000595547.5
    Conserved Domains (1) summary
    cd00190
    Location:38188
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. NM_001348178.2NP_001335107.1  kallikrein-13 isoform 3 precursor

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an alternate in-frame segment compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1.
    Source sequence(s)
    AB108823, AC011473, AY923171
    Consensus CDS
    CCDS86794.1
    UniProtKB/Swiss-Prot
    Q9UKR3
    UniProtKB/TrEMBL
    Q5BQ99
    Related
    ENSP00000334079.3, ENST00000335422.3
    Conserved Domains (1) summary
    cd00190
    Location:16109
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  3. NM_015596.3NP_056411.1  kallikrein-13 isoform 1 precursor

    See identical proteins and their annotated locations for NP_056411.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (1).
    Source sequence(s)
    AC011473, BC069334
    Consensus CDS
    CCDS12822.1
    UniProtKB/Swiss-Prot
    Q9UKR3
    UniProtKB/TrEMBL
    A0A1R3UCE9
    Related
    ENSP00000470555.1, ENST00000595793.6
    Conserved Domains (1) summary
    cd00190
    Location:38261
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RNA

  1. NR_145463.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011473, AY923171
  2. NR_145464.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011473, AY923172
  3. NR_145465.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011473, AY923173
  4. NR_145466.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011473, AY923174
  5. NR_145467.2 RNA Sequence

    Status: REVIEWED

    Source sequence(s)
    AC011473, AY923175

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20191205

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000019.10 Reference GRCh38.p13 Primary Assembly

    Range
    51055626..51065106 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_935788.1 RNA Sequence

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