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CFAP61 cilia and flagella associated protein 61 [ Homo sapiens (human) ]

Gene ID: 26074, updated on 25-Jan-2022

Summary

Official Symbol
CFAP61provided by HGNC
Official Full Name
cilia and flagella associated protein 61provided by HGNC
Primary source
HGNC:HGNC:15872
See related
Ensembl:ENSG00000089101 AllianceGenome:HGNC:15872
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
CaM-IP3; C20orf26; dJ1002M8.3; dJ1178H5.4
Summary
Predicted to be involved in cilium movement and cilium organization. Predicted to be located in axoneme and motile cilium. Predicted to colocalize with radial spoke stalk. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Biased expression in testis (RPKM 3.3), heart (RPKM 1.5) and 2 other tissues See more
Orthologs
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Genomic context

See CFAP61 in Genome Data Viewer
Location:
20p11.23
Exon count:
28
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 20 NC_000020.11 (20052532..20360698)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (20033176..20341342)

Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene Ras and Rab interactor 2 Neighboring gene ribosomal protein L12 pseudogene 12 Neighboring gene uncharacterized LOC105372553 Neighboring gene N-alpha-acetyltransferase 20, NatB catalytic subunit Neighboring gene crooked neck pre-mRNA splicing factor 1 Neighboring gene uncharacterized LOC105372554 Neighboring gene uncharacterized LOC107985413 Neighboring gene CFAP61 antisense RNA 1 Neighboring gene ribosomal protein L17 pseudogene 1 Neighboring gene RNA, 7SL, cytoplasmic 690, pseudogene Neighboring gene Sharpr-MPRA regulatory region 7426 Neighboring gene Ral GTPase activating protein catalytic subunit alpha 2 Neighboring gene INSM transcriptional repressor 1 Neighboring gene VISTA enhancer hs688

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

General gene information

Markers

Homology

Clone Names

  • DKFZp434K156

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in cilium movement ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in cilium organization ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in axoneme ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in motile cilium ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
cilia- and flagella-associated protein 61

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001167816.1NP_001161288.1  cilia- and flagella-associated protein 61 isoform 2

    See identical proteins and their annotated locations for NP_001161288.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has multiple differences, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    AL035454, AL049648, AL117439
    Consensus CDS
    CCDS54452.1
    UniProtKB/Swiss-Prot
    Q8NHU2
    Related
    ENSP00000414537.2, ENST00000451767.6
    Conserved Domains (1) summary
    pfam16092
    Location:15272
    DUF4821; Domain of unknown function (DUF4821)
  2. NM_015585.4NP_056400.3  cilia- and flagella-associated protein 61 isoform 1

    See identical proteins and their annotated locations for NP_056400.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AK307817, AL035454, AL049648, AL161658, BC028708
    Consensus CDS
    CCDS33447.1
    UniProtKB/Swiss-Prot
    Q8NHU2
    Related
    ENSP00000245957.5, ENST00000245957.10
    Conserved Domains (1) summary
    pfam16092
    Location:15272
    DUF4821; Domain of unknown function (DUF4821)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000020.11 Reference GRCh38.p13 Primary Assembly

    Range
    20052532..20360698
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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