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POLDIP2 DNA polymerase delta interacting protein 2 [ Homo sapiens (human) ]

Gene ID: 26073, updated on 8-Nov-2020

Summary

Official Symbol
POLDIP2provided by HGNC
Official Full Name
DNA polymerase delta interacting protein 2provided by HGNC
Primary source
HGNC:HGNC:23781
See related
Ensembl:ENSG00000004142 MIM:611519
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p38; POLD4; PDIP38
Summary
This gene encodes a protein that interacts with the DNA polymerase delta p50 subunit, as well as with proliferating cell nuclear antigen. The encoded protein maybe play a role in the ability of the replication fork to bypass DNA lesions. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]
Expression
Ubiquitous expression in kidney (RPKM 32.9), adrenal (RPKM 29.4) and 25 other tissues See more
Orthologs

Genomic context

See POLDIP2 in Genome Data Viewer
Location:
17q11.2
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (28346633..28357527, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (26673659..26684603, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene keratin 18 pseudogene 55 Neighboring gene transmembrane protein 97 Neighboring gene intraflagellar transport 20 Neighboring gene TNF alpha induced protein 1 Neighboring gene transmembrane protein 199 Neighboring gene microRNA 4723 Neighboring gene SEBOX homeobox

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Meta-analysis of genome-wide association studies identifies two loci associated with circulating osteoprotegerin levels.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp586F1524

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
error-free translesion synthesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
error-free translesion synthesis IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion morphogenesis IEA
Inferred from Electronic Annotation
more info
 
negative regulation of macroautophagy IEA
Inferred from Electronic Annotation
more info
 
positive regulation of mitotic cell cycle IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrial nucleoid IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
mitochondrial nucleoid IDA
Inferred from Direct Assay
more info
PubMed 
mitochondrion IDA
Inferred from Direct Assay
more info
 
nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
polymerase delta-interacting protein 2
Names
38 kDa DNA polymerase delta interaction protein
polymerase (DNA) delta interacting protein 2
polymerase (DNA-directed), delta interacting protein 2
polymerase delta interacting protein 38

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001290145.2NP_001277074.1  polymerase delta-interacting protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001277074.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
    Source sequence(s)
    BC000655, BG150599, BM809398, HY130221
    Consensus CDS
    CCDS76978.1
    UniProtKB/Swiss-Prot
    Q9Y2S7
    UniProtKB/TrEMBL
    B4DEM9
    Related
    ENSP00000477665.2, ENST00000618887.2
    Conserved Domains (2) summary
    cl01119
    Location:216337
    DUF525; Protein of unknown function (DUF525)
    cl01548
    Location:111182
    YccV-like; Hemimethylated DNA-binding protein YccV like
  2. NM_015584.5NP_056399.1  polymerase delta-interacting protein 2 isoform 1

    See identical proteins and their annotated locations for NP_056399.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    BC000655, BG150599, BM809398, HY130221
    Consensus CDS
    CCDS74018.1
    UniProtKB/Swiss-Prot
    Q9Y2S7
    Related
    ENSP00000475924.2, ENST00000540200.6
    Conserved Domains (2) summary
    cl01119
    Location:234355
    DUF525; Protein of unknown function (DUF525)
    cl01548
    Location:74200
    YccV-like; Hemimethylated DNA-binding protein YccV like

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    28346633..28357527 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

RNA

  1. XR_001752467.2 RNA Sequence

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