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RAI14 retinoic acid induced 14 [ Homo sapiens (human) ]

Gene ID: 26064, updated on 6-Nov-2022

Summary

Official Symbol
RAI14provided by HGNC
Official Full Name
retinoic acid induced 14provided by HGNC
Primary source
HGNC:HGNC:14873
See related
Ensembl:ENSG00000039560 MIM:606586; AllianceGenome:HGNC:14873
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
RAI13; NORPEG
Summary
Predicted to enable actin binding activity. Predicted to be involved in several processes, including apoptotic signaling pathway; regulation of NIK/NF-kappaB signaling; and spermatogenesis. Located in cytosol; fibrillar center; and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Broad expression in endometrium (RPKM 27.5), placenta (RPKM 14.1) and 23 other tissues See more
Orthologs
NEW
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Try the new Transcript table

Genomic context

See RAI14 in Genome Data Viewer
Location:
5p13.2
Exon count:
31
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (34656328..34832612)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (34903424..35079712)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (34656433..34832717)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105374721 Neighboring gene Sharpr-MPRA regulatory region 6534 Neighboring gene RAI14 divergent transcript Neighboring gene uncharacterized LOC124900960 Neighboring gene uncharacterized LOC124900959 Neighboring gene TTC23L antisense RNA 1 Neighboring gene tetratricopeptide repeat domain 23 like

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Genome-wide association study identifies single-nucleotide polymorphism in KCNB1 associated with left ventricular mass in humans: the HyperGEN Study.
EBI GWAS Catalog

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA1334, DKFZp564G013

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
located_in anchoring junction IEA
Inferred from Electronic Annotation
more info
 
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
 
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in fibrillar center IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
ankycorbin
Names
ankyrin repeat and coiled-coil structure-containing protein
novel retinal pigment epithelial cell protein
retinoic acid-induced protein 14

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001145520.1NP_001138992.1  ankycorbin isoform a

    See identical proteins and their annotated locations for NP_001138992.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same isoform (a).
    Source sequence(s)
    AB037755, AF155135, AY317139
    Consensus CDS
    CCDS34142.1
    UniProtKB/Swiss-Prot
    Q9P0K7, Q9Y3T5
    Related
    ENSP00000388725.2, ENST00000428746.6
    Conserved Domains (7) summary
    PRK03918
    Location:430946
    PRK03918; chromosome segregation protein; Provisional
    cd00204
    Location:81205
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:123215
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:2373
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:118149
    ANK; ANK repeat [structural motif]
    cl03075
    Location:602732
    GrpE; nucleotide exchange factor GrpE
    cl19219
    Location:589662
    DUF342; Protein of unknown function (DUF342)
  2. NM_001145521.2NP_001138993.1  ankycorbin isoform a

    See identical proteins and their annotated locations for NP_001138993.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same isoform (a).
    Source sequence(s)
    AF155135, AK308306, AY317139, BC028681, DB036130
    Consensus CDS
    CCDS34142.1
    UniProtKB/Swiss-Prot
    Q9P0K7, Q9Y3T5
    Related
    ENSP00000422942.1, ENST00000503673.5
    Conserved Domains (7) summary
    PRK03918
    Location:430946
    PRK03918; chromosome segregation protein; Provisional
    cd00204
    Location:81205
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:123215
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:2373
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:118149
    ANK; ANK repeat [structural motif]
    cl03075
    Location:602732
    GrpE; nucleotide exchange factor GrpE
    cl19219
    Location:589662
    DUF342; Protein of unknown function (DUF342)
  3. NM_001145522.2NP_001138994.1  ankycorbin isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon, compared to variant 1. This results in a shorter protein (isoform b), compared to isoform a.
    Source sequence(s)
    AF155135, AK314379, DA485361, DN994273
    Consensus CDS
    CCDS54837.1
    UniProtKB/Swiss-Prot
    Q9P0K7
    Related
    ENSP00000422377.1, ENST00000512629.5
    Conserved Domains (4) summary
    PHA03095
    Location:12224
    PHA03095; ankyrin-like protein; Provisional
    PRK03918
    Location:401917
    PRK03918; DNA double-strand break repair ATPase Rad50
    sd00045
    Location:118149
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:90182
    Ank_2; Ankyrin repeats (3 copies)
  4. NM_001145523.2NP_001138995.1  ankycorbin isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR, uses an alternate 5' coding exon, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (c) has a distinct N-terminus and is shorter than isoform a.
    Source sequence(s)
    AF155135, AY317139, AY354204
    Consensus CDS
    CCDS54838.1
    UniProtKB/Swiss-Prot
    Q9P0K7
    Related
    ENSP00000423854.1, ENST00000506376.1
    Conserved Domains (4) summary
    PHA03095
    Location:3216
    PHA03095; ankyrin-like protein; Provisional
    PRK03918
    Location:422938
    PRK03918; DNA double-strand break repair ATPase Rad50
    sd00045
    Location:110141
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:82174
    Ank_2; Ankyrin repeats (3 copies)
  5. NM_001145525.2NP_001138997.1  ankycorbin isoform d

    See identical proteins and their annotated locations for NP_001138997.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) differs in the 5' UTR, uses an alternate 5' coding exon, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (d) has a distinct N-terminus and is longer than isoform a.
    Source sequence(s)
    AF155135, AK308306, AY317139, DB036130
    Consensus CDS
    CCDS54839.1
    UniProtKB/Swiss-Prot
    Q9P0K7
    Related
    ENSP00000427123.1, ENST00000515799.5
    Conserved Domains (7) summary
    PRK03918
    Location:433949
    PRK03918; chromosome segregation protein; Provisional
    cd00204
    Location:84208
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:126218
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:2676
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:121152
    ANK; ANK repeat [structural motif]
    cl03075
    Location:605735
    GrpE; nucleotide exchange factor GrpE
    cl19219
    Location:592665
    DUF342; Protein of unknown function (DUF342)
  6. NM_015577.3NP_056392.2  ankycorbin isoform a

    See identical proteins and their annotated locations for NP_056392.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the predominant isoform (a). Variants 1-3 encode the same isoform (a).
    Source sequence(s)
    AF155135, BC028681, DA485361
    Consensus CDS
    CCDS34142.1
    UniProtKB/Swiss-Prot
    Q9P0K7, Q9Y3T5
    Related
    ENSP00000265109.3, ENST00000265109.8
    Conserved Domains (7) summary
    PRK03918
    Location:430946
    PRK03918; chromosome segregation protein; Provisional
    cd00204
    Location:81205
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:123215
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:2373
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:118149
    ANK; ANK repeat [structural motif]
    cl03075
    Location:602732
    GrpE; nucleotide exchange factor GrpE
    cl19219
    Location:589662
    DUF342; Protein of unknown function (DUF342)

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    34656328..34832612
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047417088.1XP_047273044.1  ankycorbin isoform X2

    UniProtKB/Swiss-Prot
    Q9Y3T5
  2. XM_047417092.1XP_047273048.1  ankycorbin isoform X6

    Conserved Domains (4) summary
    PHA03095
    Location:12224
    PHA03095; ankyrin-like protein; Provisional
    PRK03918
    Location:401917
    PRK03918; DNA double-strand break repair ATPase Rad50
    sd00045
    Location:118149
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:90182
    Ank_2; Ankyrin repeats (3 copies)
  3. XM_017009335.2XP_016864824.1  ankycorbin isoform X6

    UniProtKB/Swiss-Prot
    Q9P0K7
    Conserved Domains (4) summary
    PHA03095
    Location:12224
    PHA03095; ankyrin-like protein; Provisional
    PRK03918
    Location:401917
    PRK03918; DNA double-strand break repair ATPase Rad50
    sd00045
    Location:118149
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:90182
    Ank_2; Ankyrin repeats (3 copies)
  4. XM_011514021.3XP_011512323.1  ankycorbin isoform X2

    See identical proteins and their annotated locations for XP_011512323.1

    UniProtKB/Swiss-Prot
    Q9P0K7, Q9Y3T5
    Conserved Domains (7) summary
    PRK03918
    Location:430946
    PRK03918; chromosome segregation protein; Provisional
    cd00204
    Location:81205
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:123215
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:2373
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:118149
    ANK; ANK repeat [structural motif]
    cl03075
    Location:602732
    GrpE; nucleotide exchange factor GrpE
    cl19219
    Location:589662
    DUF342; Protein of unknown function (DUF342)
  5. XM_047417091.1XP_047273047.1  ankycorbin isoform X6

    Conserved Domains (4) summary
    PHA03095
    Location:12224
    PHA03095; ankyrin-like protein; Provisional
    PRK03918
    Location:401917
    PRK03918; DNA double-strand break repair ATPase Rad50
    sd00045
    Location:118149
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:90182
    Ank_2; Ankyrin repeats (3 copies)
  6. XM_011514017.3XP_011512319.1  ankycorbin isoform X2

    See identical proteins and their annotated locations for XP_011512319.1

    UniProtKB/Swiss-Prot
    Q9P0K7, Q9Y3T5
    Conserved Domains (7) summary
    PRK03918
    Location:430946
    PRK03918; chromosome segregation protein; Provisional
    cd00204
    Location:81205
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:123215
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:2373
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:118149
    ANK; ANK repeat [structural motif]
    cl03075
    Location:602732
    GrpE; nucleotide exchange factor GrpE
    cl19219
    Location:589662
    DUF342; Protein of unknown function (DUF342)
  7. XM_011514019.2XP_011512321.1  ankycorbin isoform X2

    See identical proteins and their annotated locations for XP_011512321.1

    UniProtKB/Swiss-Prot
    Q9P0K7, Q9Y3T5
    Conserved Domains (7) summary
    PRK03918
    Location:430946
    PRK03918; chromosome segregation protein; Provisional
    cd00204
    Location:81205
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:123215
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:2373
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:118149
    ANK; ANK repeat [structural motif]
    cl03075
    Location:602732
    GrpE; nucleotide exchange factor GrpE
    cl19219
    Location:589662
    DUF342; Protein of unknown function (DUF342)
  8. XM_011514020.2XP_011512322.1  ankycorbin isoform X2

    See identical proteins and their annotated locations for XP_011512322.1

    UniProtKB/Swiss-Prot
    Q9P0K7, Q9Y3T5
    Conserved Domains (7) summary
    PRK03918
    Location:430946
    PRK03918; chromosome segregation protein; Provisional
    cd00204
    Location:81205
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:123215
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:2373
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:118149
    ANK; ANK repeat [structural motif]
    cl03075
    Location:602732
    GrpE; nucleotide exchange factor GrpE
    cl19219
    Location:589662
    DUF342; Protein of unknown function (DUF342)
  9. XM_011514018.2XP_011512320.1  ankycorbin isoform X2

    See identical proteins and their annotated locations for XP_011512320.1

    UniProtKB/Swiss-Prot
    Q9P0K7, Q9Y3T5
    Conserved Domains (7) summary
    PRK03918
    Location:430946
    PRK03918; chromosome segregation protein; Provisional
    cd00204
    Location:81205
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:123215
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:2373
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:118149
    ANK; ANK repeat [structural motif]
    cl03075
    Location:602732
    GrpE; nucleotide exchange factor GrpE
    cl19219
    Location:589662
    DUF342; Protein of unknown function (DUF342)
  10. XM_047417089.1XP_047273045.1  ankycorbin isoform X2

    UniProtKB/Swiss-Prot
    Q9Y3T5
  11. XM_006714469.3XP_006714532.1  ankycorbin isoform X2

    See identical proteins and their annotated locations for XP_006714532.1

    UniProtKB/Swiss-Prot
    Q9P0K7, Q9Y3T5
    Conserved Domains (7) summary
    PRK03918
    Location:430946
    PRK03918; chromosome segregation protein; Provisional
    cd00204
    Location:81205
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:123215
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:2373
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:118149
    ANK; ANK repeat [structural motif]
    cl03075
    Location:602732
    GrpE; nucleotide exchange factor GrpE
    cl19219
    Location:589662
    DUF342; Protein of unknown function (DUF342)
  12. XM_011514022.2XP_011512324.1  ankycorbin isoform X2

    See identical proteins and their annotated locations for XP_011512324.1

    UniProtKB/Swiss-Prot
    Q9P0K7, Q9Y3T5
    Conserved Domains (7) summary
    PRK03918
    Location:430946
    PRK03918; chromosome segregation protein; Provisional
    cd00204
    Location:81205
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    pfam12796
    Location:123215
    Ank_2; Ankyrin repeats (3 copies)
    pfam13637
    Location:2373
    Ank_4; Ankyrin repeats (many copies)
    sd00045
    Location:118149
    ANK; ANK repeat [structural motif]
    cl03075
    Location:602732
    GrpE; nucleotide exchange factor GrpE
    cl19219
    Location:589662
    DUF342; Protein of unknown function (DUF342)
  13. XM_047417090.1XP_047273046.1  ankycorbin isoform X5

  14. XM_024446017.2XP_024301785.1  ankycorbin isoform X3

    Conserved Domains (5) summary
    cd00204
    Location:73197
    ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
    sd00045
    Location:110141
    ANK; ANK repeat [structural motif]
    pfam12796
    Location:181240
    Ank_2; Ankyrin repeats (3 copies)
    pfam13857
    Location:2785
    Ank_5; Ankyrin repeats (many copies)
    cl25732
    Location:422938
    SMC_N; RecF/RecN/SMC N terminal domain
  15. XM_011514016.3XP_011512318.2  ankycorbin isoform X1

  16. XM_011514025.3XP_011512327.2  ankycorbin isoform X4

  17. XM_047417093.1XP_047273049.1  ankycorbin isoform X7

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    34903424..35079712
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)