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RAB11FIP5 RAB11 family interacting protein 5 [ Homo sapiens (human) ]

Gene ID: 26056, updated on 17-Jun-2019

Summary

Official Symbol
RAB11FIP5provided by HGNC
Official Full Name
RAB11 family interacting protein 5provided by HGNC
Primary source
HGNC:HGNC:24845
See related
Ensembl:ENSG00000135631 MIM:605536
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
GAF1; pp75; RIP11
Expression
Broad expression in testis (RPKM 48.5), kidney (RPKM 16.7) and 18 other tissues See more
Orthologs

Genomic context

See RAB11FIP5 in Genome Data Viewer
Location:
2p13.2
Exon count:
5
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (73073382..73112948, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (73300510..73340146, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene sideroflexin 5 Neighboring gene uncharacterized LOC107985897 Neighboring gene uncharacterized LOC105374800 Neighboring gene Sharpr-MPRA regulatory region 2018 Neighboring gene notochord homeobox Neighboring gene SMYD family member 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

Pathways from BioSystems

  • Endocytosis, organism-specific biosystem (from KEGG)
    Endocytosis, organism-specific biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...
  • Endocytosis, conserved biosystem (from KEGG)
    Endocytosis, conserved biosystemEndocytosis is a mechanism for cells to remove ligands, nutrients, and plasma membrane (PM) proteins, and lipids from the cell surface, bringing them into the cell interior. Transmembrane proteins en...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: SFXN5

Homology

Clone Names

  • KIAA0857, DKFZp434H018

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Rab GTPase binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
gamma-tubulin binding IDA
Inferred from Direct Assay
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
cellular response to acidic pH IDA
Inferred from Direct Assay
more info
PubMed 
insulin secretion involved in cellular response to glucose stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
negative regulation of adiponectin secretion IDA
Inferred from Direct Assay
more info
PubMed 
regulated exocytosis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
regulated exocytosis ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of protein localization to cell surface IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
early endosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
early endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
early endosome membrane IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
intracellular membrane-bounded organelle IDA
Inferred from Direct Assay
more info
 
microtubule organizing center IDA
Inferred from Direct Assay
more info
 
mitochondrial outer membrane IDA
Inferred from Direct Assay
more info
PubMed 
recycling endosome ISS
Inferred from Sequence or Structural Similarity
more info
 
recycling endosome membrane IEA
Inferred from Electronic Annotation
more info
 
secretory granule ISS
Inferred from Sequence or Structural Similarity
more info
 
transport vesicle membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
rab11 family-interacting protein 5
Names
RAB11 family interacting protein 5 (class I)
gaf-1
gamma-SNAP-associated factor 1
phosphoprotein pp75
rab11-FIP5
rab11-interacting protein Rip11

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015470.3NP_056285.1  rab11 family-interacting protein 5

    See identical proteins and their annotated locations for NP_056285.1

    Status: VALIDATED

    Source sequence(s)
    AB020664, AC010913, AL117579
    Consensus CDS
    CCDS1923.1
    UniProtKB/Swiss-Prot
    Q9BXF6
    UniProtKB/TrEMBL
    Q9UFM0
    Related
    ENSP00000258098.6, ENST00000258098.6
    Conserved Domains (2) summary
    pfam09457
    Location:601648
    RBD-FIP; FIP domain
    cl14603
    Location:21167
    C2; C2 domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    73073382..73112948 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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