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ZNF500 zinc finger protein 500 [ Homo sapiens (human) ]

Gene ID: 26048, updated on 23-Nov-2021

Summary

Official Symbol
ZNF500provided by HGNC
Official Full Name
zinc finger protein 500provided by HGNC
Primary source
HGNC:HGNC:23716
See related
Ensembl:ENSG00000103199
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ZSCAN50; ZKSCAN18
Expression
Ubiquitous expression in testis (RPKM 3.6), spleen (RPKM 2.4) and 25 other tissues See more
Orthologs
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Genomic context

See ZNF500 in Genome Data Viewer
Location:
16p13.3
Exon count:
9
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 16 NC_000016.10 (4745961..4767219, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (4798240..4817163, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene mahogunin ring finger 1 Neighboring gene nudix hydrolase 16 like 1 Neighboring gene ankyrin repeat and sterile alpha motif domain containing 3 Neighboring gene Sharpr-MPRA regulatory region 8628 Neighboring gene dynein axonemal assembly factor 8 Neighboring gene septin 12 Neighboring gene small integral membrane protein 22 Neighboring gene rogdi atypical leucine zipper

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
zinc finger protein 500
Names
zinc finger protein with KRAB and SCAN domains 18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001303450.2NP_001290379.1  zinc finger protein 500 isoform 2

    See identical proteins and their annotated locations for NP_001290379.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate segment in the 3' coding region compared to variant 1, that causes a frameshift. The resulting isoform (2) has a shorter and distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AB011129, AC020663, AK297993
    Consensus CDS
    CCDS76814.1
    UniProtKB/Swiss-Prot
    O60304
    Related
    ENSP00000445714.1, ENST00000545009.1
    Conserved Domains (7) summary
    smart00431
    Location:46151
    SCAN; leucine rich region
    cd07765
    Location:224247
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:321380
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:327347
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:325347
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:46134
    SCAN; SCAN domain
    pfam13465
    Location:367392
    zf-H2C2_2; Zinc-finger double domain
  2. NM_021646.4NP_067678.1  zinc finger protein 500 isoform 1

    See identical proteins and their annotated locations for NP_067678.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AB011129, AC020663, AK291792, BM678198
    Consensus CDS
    CCDS32383.1
    UniProtKB/Swiss-Prot
    O60304
    Related
    ENSP00000219478.5, ENST00000219478.11
    Conserved Domains (7) summary
    smart00431
    Location:46151
    SCAN; leucine rich region
    cd07765
    Location:224247
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:320459
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:327347
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:325347
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:46134
    SCAN; SCAN domain
    pfam13465
    Location:367392
    zf-H2C2_2; Zinc-finger double domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p13 Primary Assembly

    Range
    4745961..4767219 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011522453.2XP_011520755.1  zinc finger protein 500 isoform X1

    Conserved Domains (7) summary
    smart00431
    Location:46151
    SCAN; leucine rich region
    cd07765
    Location:224247
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:363437
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:327347
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:325347
    zf-C2H2; Zinc finger, C2H2 type
    pfam02023
    Location:46134
    SCAN; SCAN domain
    pfam13465
    Location:367392
    zf-H2C2_2; Zinc-finger double domain
  2. XM_011522454.3XP_011520756.1  zinc finger protein 500 isoform X3

    See identical proteins and their annotated locations for XP_011520756.1

    UniProtKB/TrEMBL
    Q0VAL1
    Conserved Domains (5) summary
    cd07765
    Location:1639
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:112251
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:119139
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:117139
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:159184
    zf-H2C2_2; Zinc-finger double domain
  3. XM_005255243.4XP_005255300.1  zinc finger protein 500 isoform X2

    Conserved Domains (5) summary
    cd07765
    Location:107130
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:203342
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:210230
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:208230
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:250275
    zf-H2C2_2; Zinc-finger double domain
  4. XM_017023121.2XP_016878610.1  zinc finger protein 500 isoform X3

    UniProtKB/TrEMBL
    Q0VAL1
    Conserved Domains (5) summary
    cd07765
    Location:1639
    KRAB_A-box; KRAB (Kruppel-associated box) domain -A box
    COG5048
    Location:112251
    COG5048; FOG: Zn-finger [General function prediction only]
    sd00017
    Location:119139
    ZF_C2H2; C2H2 Zn finger [structural motif]
    pfam00096
    Location:117139
    zf-C2H2; Zinc finger, C2H2 type
    pfam13465
    Location:159184
    zf-H2C2_2; Zinc-finger double domain
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