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LRRTM2 leucine rich repeat transmembrane neuronal 2 [ Homo sapiens (human) ]

Gene ID: 26045, updated on 18-Aug-2020

Summary

Official Symbol
LRRTM2provided by HGNC
Official Full Name
leucine rich repeat transmembrane neuronal 2provided by HGNC
Primary source
HGNC:HGNC:19409
See related
Ensembl:ENSG00000146006 MIM:610868
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Biased expression in brain (RPKM 12.7), placenta (RPKM 1.4) and 2 other tissues See more
Orthologs

Genomic context

See LRRTM2 in Genome Data Viewer
Location:
5q31.2
Exon count:
2
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 5 NC_000005.10 (138868921..138875335, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (138205079..138211057, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 9755 Neighboring gene uncharacterized LOC105379194 Neighboring gene catenin alpha 1 Neighboring gene uncharacterized LOC105379195 Neighboring gene SIL1 nucleotide exchange factor Neighboring gene RNA, 5S ribosomal pseudogene 194

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ52416, FLJ76283, FLJ99831

Gene Ontology Provided by GOA

Function Evidence Code Pubs
neurexin family protein binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
long-term synaptic potentiation IEA
Inferred from Electronic Annotation
more info
 
negative regulation of receptor internalization IEA
Inferred from Electronic Annotation
more info
 
positive regulation of synapse assembly IEA
Inferred from Electronic Annotation
more info
 
regulation of postsynaptic density assembly IEA
Inferred from Electronic Annotation
more info
 
synapse organization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
GABA-ergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
GABA-ergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
excitatory synapse IEA
Inferred from Electronic Annotation
more info
 
extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
hippocampal mossy fiber to CA3 synapse IEA
Inferred from Electronic Annotation
more info
 
integral component of postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of postsynaptic specialization membrane IDA
Inferred from Direct Assay
more info
PubMed 
integral component of postsynaptic specialization membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
leucine-rich repeat transmembrane neuronal protein 2
Names
leucine-rich repeat neuronal 2 protein
leucine-rich repeat transmembrane neuronal 2 protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015564.3NP_056379.1  leucine-rich repeat transmembrane neuronal protein 2 precursor

    See identical proteins and their annotated locations for NP_056379.1

    Status: VALIDATED

    Source sequence(s)
    AB007876, AC011405, DA400927
    Consensus CDS
    CCDS47272.1
    UniProtKB/Swiss-Prot
    O43300
    Related
    ENSP00000274711.5, ENST00000274711.7
    Conserved Domains (3) summary
    TIGR00864
    Location:284351
    PCC; polycystin cation channel protein
    COG4886
    Location:65312
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:6686
    LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p13 Primary Assembly

    Range
    138868921..138875335 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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