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LRRTM2 leucine rich repeat transmembrane neuronal 2 [ Homo sapiens (human) ]

Gene ID: 26045, updated on 22-Sep-2022

Summary

Official Symbol
LRRTM2provided by HGNC
Official Full Name
leucine rich repeat transmembrane neuronal 2provided by HGNC
Primary source
HGNC:HGNC:19409
See related
Ensembl:ENSG00000146006 MIM:610868; AllianceGenome:HGNC:19409
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
Predicted to enable neurexin family protein binding activity. Predicted to be involved in regulation of postsynaptic density assembly. Predicted to act upstream of or within several processes, including long-term synaptic potentiation; negative regulation of receptor internalization; and positive regulation of synapse assembly. Is active in GABA-ergic synapse. Is integral component of postsynaptic specialization membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in brain (RPKM 12.7), placenta (RPKM 1.4) and 2 other tissues See more
Orthologs
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Genomic context

See LRRTM2 in Genome Data Viewer
Location:
5q31.2
Exon count:
2
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (138868921..138875335, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (139395050..139401453, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (138204610..138211024, complement)

Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 9755 Neighboring gene CTNNA1 antisense RNA 1 Neighboring gene catenin alpha 1 Neighboring gene uncharacterized LOC124901079 Neighboring gene SIL1 nucleotide exchange factor Neighboring gene uncharacterized LOC124901080 Neighboring gene RNA, 5S ribosomal pseudogene 194

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ52416, FLJ76283, FLJ99831

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables neurexin family protein binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in long-term synaptic potentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of receptor internalization IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of synapse assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of postsynaptic density assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in synapse organization IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in GABA-ergic synapse IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in GABA-ergic synapse IMP
Inferred from Mutant Phenotype
more info
PubMed 
located_in Schaffer collateral - CA1 synapse IEA
Inferred from Electronic Annotation
more info
 
located_in excitatory synapse IEA
Inferred from Electronic Annotation
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in glutamatergic synapse IEA
Inferred from Electronic Annotation
more info
 
located_in hippocampal mossy fiber to CA3 synapse IEA
Inferred from Electronic Annotation
more info
 
located_in postsynaptic density membrane IEA
Inferred from Electronic Annotation
more info
 
is_active_in postsynaptic specialization membrane IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in postsynaptic specialization membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 

General protein information

Preferred Names
leucine-rich repeat transmembrane neuronal protein 2
Names
leucine-rich repeat neuronal 2 protein
leucine-rich repeat transmembrane neuronal 2 protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015564.3NP_056379.1  leucine-rich repeat transmembrane neuronal protein 2 precursor

    See identical proteins and their annotated locations for NP_056379.1

    Status: VALIDATED

    Source sequence(s)
    AB007876, AC011405, DA400927
    Consensus CDS
    CCDS47272.1
    UniProtKB/Swiss-Prot
    O43300, Q7L770
    Related
    ENSP00000274711.5, ENST00000274711.7
    Conserved Domains (3) summary
    TIGR00864
    Location:284351
    PCC; polycystin cation channel protein
    COG4886
    Location:65312
    LRR; Leucine-rich repeat (LRR) protein [Transcription]
    sd00033
    Location:6686
    LRR_RI; leucine-rich repeat [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

    Range
    138868921..138875335 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060929.1 Alternate T2T-CHM13v2.0

    Range
    139395050..139401453 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)