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UBXN7 UBX domain protein 7 [ Homo sapiens (human) ]

Gene ID: 26043, updated on 3-Dec-2022

Summary

Official Symbol
UBXN7provided by HGNC
Official Full Name
UBX domain protein 7provided by HGNC
Primary source
HGNC:HGNC:29119
See related
Ensembl:ENSG00000163960 MIM:616379; AllianceGenome:HGNC:29119
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
UBXD7
Summary
Enables ubiquitin binding activity and ubiquitin protein ligase binding activity. Located in nuclear body. Part of VCP-NPL4-UFD1 AAA ATPase complex. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in bone marrow (RPKM 8.3), testis (RPKM 7.0) and 25 other tissues See more
Orthologs
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Genomic context

See UBXN7 in Genome Data Viewer
Location:
3q29
Exon count:
11
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (196347662..196432427, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (199066970..199151765, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (196074533..196159298, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr3:196064783-196065982 Neighboring gene RNA, U6 small nuclear 910, pseudogene Neighboring gene RNA, U6 small nuclear 1279, pseudogene Neighboring gene RNA, 7SL, cytoplasmic 434, pseudogene Neighboring gene RNA, 7SL, cytoplasmic 738, pseudogene Neighboring gene UBXN7 antisense RNA 1 Neighboring gene ring finger protein 168 Neighboring gene uncharacterized LOC105374306 Neighboring gene uncharacterized LOC105374307 Neighboring gene single-pass membrane protein with coiled-coil domains 1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0794

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables ubiquitin binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables ubiquitin binding IDA
Inferred from Direct Assay
more info
PubMed 
enables ubiquitin protein ligase binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
part_of VCP-NPL4-UFD1 AAA ATPase complex IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
UBX domain-containing protein 7
Names
UBX domain containing 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015562.2NP_056377.1  UBX domain-containing protein 7

    See identical proteins and their annotated locations for NP_056377.1

    Status: VALIDATED

    Source sequence(s)
    AB018337, AC069257, BC028986, BC047420, BG253663, DA119173
    Consensus CDS
    CCDS43191.1
    UniProtKB/Swiss-Prot
    O94888, Q8N327
    Related
    ENSP00000296328.4, ENST00000296328.9
    Conserved Domains (3) summary
    cd02958
    Location:149261
    UAS; UAS family; UAS is a domain of unknown function. Most members of this family are uncharacterized proteins with similarity to FAS-associated factor 1 (FAF1) and ETEA because of the presence of a UAS domain N-terminal to a ubiquitin-associated UBX domain. ...
    cd14345
    Location:1651
    UBA_UBXD7; UBA-like domain found in UBX domain-containing protein 7 (UBXD7) and similar proteins
    cd01773
    Location:412487
    UBX_UBXN7; Ubiquitin regulatory domain X (UBX) found in UBX domain protein 7 (UBXN7) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

    Range
    196347662..196432427 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011512671.3XP_011510973.1  UBX domain-containing protein 7 isoform X1

    Related
    ENSP00000397256.1, ENST00000428095.1
    Conserved Domains (2) summary
    cd01773
    Location:260341
    Faf1_like1_UBX; Faf1 ike-1 UBX domain
    cd02958
    Location:1113
    UAS; UAS family; UAS is a domain of unknown function. Most members of this family are uncharacterized proteins with similarity to FAS-associated factor 1 (FAF1) and ETEA because of the presence of a UAS domain N-terminal to a ubiquitin-associated UBX domain. ...

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060927.1 Alternate T2T-CHM13v2.0

    Range
    199066970..199151765 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)