U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

PRSS33 serine protease 33 [ Homo sapiens (human) ]

Gene ID: 260429, updated on 26-Oct-2022

Summary

Official Symbol
PRSS33provided by HGNC
Official Full Name
serine protease 33provided by HGNC
Primary source
HGNC:HGNC:30405
See related
Ensembl:ENSG00000103355 MIM:613797; AllianceGenome:HGNC:30405
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
EOS
Summary
Enables serine-type endopeptidase activity. Involved in protein kinase C signaling and proteolysis. Located in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Low expression observed in reference dataset See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See PRSS33 in Genome Data Viewer
Location:
16p13.3
Exon count:
8
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (2783953..2787915, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (2804168..2808494, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (2833954..2837916, complement)

Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene serine/arginine repetitive matrix 2 Neighboring gene elongin B Neighboring gene small nucleolar RNA, H/ACA box 3C Neighboring gene serine protease 41

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables serine-type endopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables serine-type endopeptidase activity IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
involved_in protein kinase C signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in proteolysis IDA
Inferred from Direct Assay
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
serine protease 33
Names
protease, serine 33
serine protease EOS

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001385462.1NP_001372391.1  serine protease 33 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longest transcript. Variants 1-4 all encode the same protein.
    Source sequence(s)
    AC092117
    Consensus CDS
    CCDS42110.1
    UniProtKB/Swiss-Prot
    Q8N171
    Conserved Domains (1) summary
    cd00190
    Location:37275
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  2. NM_001385463.1NP_001372392.1  serine protease 33 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.
    Source sequence(s)
    AC092117
    Consensus CDS
    CCDS42110.1
    UniProtKB/Swiss-Prot
    Q8N171
    Conserved Domains (1) summary
    cd00190
    Location:37275
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  3. NM_001385464.1NP_001372393.1  serine protease 33 precursor

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.
    Source sequence(s)
    AC092117
    Consensus CDS
    CCDS42110.1
    UniProtKB/Swiss-Prot
    Q8N171
    Related
    ENSP00000458369.1, ENST00000570702.5
    Conserved Domains (1) summary
    cd00190
    Location:37275
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...
  4. NM_152891.3NP_690851.2  serine protease 33 precursor

    See identical proteins and their annotated locations for NP_690851.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-4 all encode the same protein.
    Source sequence(s)
    AC092117
    Consensus CDS
    CCDS42110.1
    UniProtKB/Swiss-Prot
    Q8N171, Q8NF86
    Related
    ENSP00000507560.1, ENST00000682474.1
    Conserved Domains (1) summary
    cd00190
    Location:37275
    Tryp_SPc; Trypsin-like serine protease; Many of these are synthesized as inactive precursor zymogens that are cleaved during limited proteolysis to generate their active forms. Alignment contains also inactive enzymes that have substitutions of the catalytic triad ...

RNA

  1. NR_169625.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC092117

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

    Range
    2783953..2787915 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060940.1 Alternate T2T-CHM13v2.0

    Range
    2804168..2808494 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)