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GLCE glucuronic acid epimerase [ Homo sapiens (human) ]

Gene ID: 26035, updated on 11-Sep-2019

Summary

Official Symbol
GLCEprovided by HGNC
Official Full Name
glucuronic acid epimeraseprovided by HGNC
Primary source
HGNC:HGNC:17855
See related
Ensembl:ENSG00000138604 MIM:612134
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSEPI
Expression
Ubiquitous expression in colon (RPKM 5.9), duodenum (RPKM 5.7) and 25 other tissues See more
Orthologs

Genomic context

See GLCE in Genome Data Viewer
Location:
15q23
Exon count:
10
Annotation release Status Assembly Chr Location
109.20190905 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (69160555..69272209)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (69452921..69564546)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene NADPH oxidase 5 Neighboring gene ATP binding cassette subfamily G member 2 (Junior blood group) pseudogene Neighboring gene Ewing sarcoma associated transcript 1 Neighboring gene family with sequence similarity 47 member C pseudogene Neighboring gene RNA, 7SL, cytoplasmic 438, pseudogene Neighboring gene uncharacterized LOC102723548 Neighboring gene Sharpr-MPRA regulatory region 4882 Neighboring gene progestin and adipoQ receptor family member 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of glucuronic acid epimerase (GLCE) in primary human brain microvascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0836

Gene Ontology Provided by GOA

Process Evidence Code Pubs
heparan sulfate proteoglycan biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
heparan sulfate proteoglycan biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
heparan sulfate proteoglycan biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
heparin biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
heparin biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
 
Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
D-glucuronyl C5-epimerase
Names
UDP-glucuronic acid epimerase
glucuronyl C5-epimerase
heparan sulfate C5-epimerase
heparan sulfate epimerase
heparin/heparan sulfate-glucuronic acid C5-epimerase
heparosan-N-sulfate-glucuronate 5-epimerase
NP_001311020.1
NP_001311021.1
NP_001311022.1
NP_001311023.1
NP_056369.1
XP_005254355.1
XP_016877562.1
XP_016877563.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324091.1NP_001311020.1  D-glucuronyl C5-epimerase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC026512, AC026992
  2. NM_001324092.2NP_001311021.1  D-glucuronyl C5-epimerase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC026512, AC026992
  3. NM_001324093.2NP_001311022.1  D-glucuronyl C5-epimerase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC026512, AC026992
    Consensus CDS
    CCDS32277.1
    UniProtKB/Swiss-Prot
    O94923
    Conserved Domains (1) summary
    pfam06662
    Location:416607
    C5-epim_C; D-glucuronyl C5-epimerase C-terminus
  4. NM_001324094.2NP_001311023.1  D-glucuronyl C5-epimerase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC026512, AC026992
    Consensus CDS
    CCDS32277.1
    UniProtKB/Swiss-Prot
    O94923
    Conserved Domains (1) summary
    pfam06662
    Location:416607
    C5-epim_C; D-glucuronyl C5-epimerase C-terminus
  5. NM_015554.3NP_056369.1  D-glucuronyl C5-epimerase isoform 1

    See identical proteins and their annotated locations for NP_056369.1

    Status: VALIDATED

    Source sequence(s)
    AC026512, AC026992
    Consensus CDS
    CCDS32277.1
    UniProtKB/Swiss-Prot
    O94923
    Related
    ENSP00000261858.2, ENST00000261858.7
    Conserved Domains (1) summary
    pfam06662
    Location:416607
    C5-epim_C; D-glucuronyl C5-epimerase C-terminus

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    69160555..69272209
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005254298.3XP_005254355.1  D-glucuronyl C5-epimerase isoform X2

    See identical proteins and their annotated locations for XP_005254355.1

    UniProtKB/Swiss-Prot
    O94923
    Conserved Domains (1) summary
    pfam06662
    Location:416607
    C5-epim_C; D-glucuronyl C5-epimerase C-terminus
  2. XM_017022073.1XP_016877562.1  D-glucuronyl C5-epimerase isoform X1

  3. XM_017022074.2XP_016877563.1  D-glucuronyl C5-epimerase isoform X3

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