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GLCE glucuronic acid epimerase [ Homo sapiens (human) ]

Gene ID: 26035, updated on 22-Sep-2022

Summary

Official Symbol
GLCEprovided by HGNC
Official Full Name
glucuronic acid epimeraseprovided by HGNC
Primary source
HGNC:HGNC:17855
See related
Ensembl:ENSG00000138604 MIM:612134; AllianceGenome:HGNC:17855
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
HSEPI
Summary
Enables calcium ion binding activity; heparosan-N-sulfate-glucuronate 5-epimerase activity; and protein homodimerization activity. Involved in heparan sulfate proteoglycan biosynthetic process. Predicted to be located in Golgi membrane. Predicted to be integral component of membrane. Predicted to be active in Golgi apparatus. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in colon (RPKM 5.9), duodenum (RPKM 5.7) and 25 other tissues See more
Orthologs
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Genomic context

See GLCE in Genome Data Viewer
Location:
15q23
Exon count:
12
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (69160635..69272207)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (66983187..67094669)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (69452974..69564546)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124903516 Neighboring gene Ewing sarcoma associated transcript 1 Neighboring gene family with sequence similarity 47 member C pseudogene Neighboring gene RNA, 7SL, cytoplasmic 438, pseudogene Neighboring gene PAQR5 divergent transcript Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr15:69597275-69598474 Neighboring gene small nucleolar RNA SNORA77 Neighboring gene progestin and adipoQ receptor family member 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat Microarray analysis indicates HIV-1 Tat-induced upregulation of glucuronic acid epimerase (GLCE) in primary human brain microvascular endothelial cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0836

Gene Ontology Provided by GOA

Process Evidence Code Pubs
involved_in heparan sulfate proteoglycan biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in heparan sulfate proteoglycan biosynthetic process IDA
Inferred from Direct Assay
more info
PubMed 
involved_in heparan sulfate proteoglycan biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in heparan sulfate proteoglycan biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in heparin biosynthetic process IEA
Inferred from Electronic Annotation
more info
 
involved_in heparin biosynthetic process ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi apparatus ISS
Inferred from Sequence or Structural Similarity
more info
 
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
D-glucuronyl C5-epimerase
Names
UDP-glucuronic acid epimerase
glucuronyl C5-epimerase
heparan sulfate C5-epimerase
heparan sulfate epimerase
heparin/heparan sulfate-glucuronic acid C5-epimerase
heparosan-N-sulfate-glucuronate 5-epimerase
NP_001311020.1
NP_001311021.1
NP_001311022.1
NP_001311023.1
NP_056369.1
XP_016877562.1
XP_016877563.1
XP_047288332.1
XP_047288333.1
XP_047288335.1
XP_047288336.1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001324091.2NP_001311020.1  D-glucuronyl C5-epimerase isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC026512, AC026992
  2. NM_001324092.2NP_001311021.1  D-glucuronyl C5-epimerase isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC026512, AC026992
  3. NM_001324093.2NP_001311022.1  D-glucuronyl C5-epimerase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC026512, AC026992
    Consensus CDS
    CCDS32277.1
    UniProtKB/Swiss-Prot
    O94923, Q6GUQ2
    Conserved Domains (1) summary
    pfam06662
    Location:416607
    C5-epim_C; D-glucuronyl C5-epimerase C-terminus
  4. NM_001324094.2NP_001311023.1  D-glucuronyl C5-epimerase isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC026512, AC026992
    Consensus CDS
    CCDS32277.1
    UniProtKB/Swiss-Prot
    O94923, Q6GUQ2
    Conserved Domains (1) summary
    pfam06662
    Location:416607
    C5-epim_C; D-glucuronyl C5-epimerase C-terminus
  5. NM_015554.3NP_056369.1  D-glucuronyl C5-epimerase isoform 1

    See identical proteins and their annotated locations for NP_056369.1

    Status: VALIDATED

    Source sequence(s)
    AC026512, AC026992
    Consensus CDS
    CCDS32277.1
    UniProtKB/Swiss-Prot
    O94923, Q6GUQ2
    Related
    ENSP00000261858.2, ENST00000261858.7
    Conserved Domains (1) summary
    pfam06662
    Location:416607
    C5-epim_C; D-glucuronyl C5-epimerase C-terminus

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    69160635..69272207
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432377.1XP_047288333.1  D-glucuronyl C5-epimerase isoform X1

  2. XM_047432376.1XP_047288332.1  D-glucuronyl C5-epimerase isoform X1

  3. XM_047432380.1XP_047288336.1  D-glucuronyl C5-epimerase isoform X3

  4. XM_047432379.1XP_047288335.1  D-glucuronyl C5-epimerase isoform X1

  5. XM_017022073.2XP_016877562.1  D-glucuronyl C5-epimerase isoform X2

  6. XM_017022074.3XP_016877563.1  D-glucuronyl C5-epimerase isoform X4

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    66983187..67094669
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)