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IPCEF1 interaction protein for cytohesin exchange factors 1 [ Homo sapiens (human) ]

Gene ID: 26034, updated on 26-Oct-2022

Summary

Official Symbol
IPCEF1provided by HGNC
Official Full Name
interaction protein for cytohesin exchange factors 1provided by HGNC
Primary source
HGNC:HGNC:21204
See related
Ensembl:ENSG00000074706 MIM:619948; AllianceGenome:HGNC:21204
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
PIP3E; PIP3-E
Summary
Predicted to enable peroxidase activity. Predicted to be involved in response to oxidative stress. Predicted to be located in cytosol and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in thyroid (RPKM 13.5), brain (RPKM 6.8) and 9 other tissues See more
Orthologs
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Genomic context

See IPCEF1 in Genome Data Viewer
Location:
6q25.2
Exon count:
15
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (154154496..154356803, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (155356475..155558805, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (154475631..154677937, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 896, pseudogene Neighboring gene high mobility group box 3 pseudogene 19 Neighboring gene opioid receptor mu 1 Neighboring gene ribosomal protein L17 pseudogene 24 Neighboring gene uncharacterized LOC105378067 Neighboring gene CNKSR family member 3 Neighboring gene Sharpr-MPRA regulatory region 5073

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

EBI GWAS Catalog

Description
A genome-wide association study identifies multiple susceptibility loci for chronic lymphocytic leukemia.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: CNKSR1

Homology

Clone Names

  • KIAA0403

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables oxygen carrier activity NAS
Non-traceable Author Statement
more info
PubMed 
enables peroxidase activity ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in cellular oxidant detoxification IEA
Inferred from Electronic Annotation
more info
 
involved_in oxygen transport NAS
Non-traceable Author Statement
more info
PubMed 
involved_in response to oxidative stress ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
interactor protein for cytohesin exchange factors 1
Names
interaction protein for cytohesin exchange factors 1 Interaction protein for cytohesin exchange factors 1
phosphoinositide-binding protein PIP3-E

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001130699.2NP_001124171.1  interactor protein for cytohesin exchange factors 1 isoform 1

    See identical proteins and their annotated locations for NP_001124171.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1). Variants 1, 2, and 4-6 all encode the same isoform (1).
    Source sequence(s)
    AB007863, BU075081, BX647254
    Consensus CDS
    CCDS47509.1
    UniProtKB/Swiss-Prot
    Q8WWN9
    Related
    ENSP00000394751.2, ENST00000422970.6
    Conserved Domains (1) summary
    cd01260
    Location:31144
    PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
  2. NM_001130700.2NP_001124172.1  interactor protein for cytohesin exchange factors 1 isoform 1

    See identical proteins and their annotated locations for NP_001124172.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has an alternate 5' UTR, as compared to variant 1. Variants 1, 2, and 4-6 all encode the same isoform (1).
    Source sequence(s)
    AB007863, AJ310566, AK289917, AL033376, BU075081, BX647254
    Consensus CDS
    CCDS47509.1
    UniProtKB/Swiss-Prot
    Q8WWN9
    Related
    ENSP00000356189.4, ENST00000367220.9
    Conserved Domains (1) summary
    cd01260
    Location:31144
    PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
  3. NM_001394799.1NP_001381728.1  interactor protein for cytohesin exchange factors 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL033376, AL132774, AL445220
    Consensus CDS
    CCDS47509.1
    Conserved Domains (1) summary
    cd01260
    Location:31144
    PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
  4. NM_001394800.1NP_001381729.1  interactor protein for cytohesin exchange factors 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL033376, AL132774, AL445220
    Consensus CDS
    CCDS47509.1
    Conserved Domains (1) summary
    cd01260
    Location:31144
    PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
  5. NM_001394801.1NP_001381730.1  interactor protein for cytohesin exchange factors 1 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AL033376, AL132774, AL445220
    Consensus CDS
    CCDS47509.1
    Conserved Domains (1) summary
    cd01260
    Location:31144
    PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
  6. NM_001394802.1NP_001381731.1  interactor protein for cytohesin exchange factors 1 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AL033376, AL132774, AL445220
    Consensus CDS
    CCDS5245.1
    UniProtKB/Swiss-Prot
    Q5HYL8
    Related
    ENSP00000430287.1, ENST00000519344.5
    Conserved Domains (1) summary
    cd01260
    Location:30143
    PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain
  7. NM_015553.3NP_056368.1  interactor protein for cytohesin exchange factors 1 isoform 2

    See identical proteins and their annotated locations for NP_056368.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has an alternate 5' UTR and has an alternate splice site in the 5' coding region, as compared to variant 1. The resulting isoform (2) is one amino acid shorter than isoform 1. Variants 3 and 7 both encode the same isoform (2).
    Source sequence(s)
    AB007863, AJ310566, AL033376, BC105043, BU075081, BX647254
    Consensus CDS
    CCDS5245.1
    UniProtKB/Swiss-Prot
    Q5HYL8, Q8WWN9
    Related
    ENSP00000265198.4, ENST00000265198.8
    Conserved Domains (1) summary
    cd01260
    Location:30143
    PH_CNK_mammalian-like; Connector enhancer of KSR (Kinase suppressor of ras) (CNK) pleckstrin homology (PH) domain

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

    Range
    154154496..154356803 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060930.1 Alternate T2T-CHM13v2.0

    Range
    155356475..155558805 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)