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TUBB8B tubulin beta 8B [ Homo sapiens (human) ]

Gene ID: 260334, updated on 23-Nov-2021

Summary

Official Symbol
TUBB8Bprovided by HGNC
Official Full Name
tubulin beta 8Bprovided by HGNC
Primary source
HGNC:HGNC:24983
See related
Ensembl:ENSG00000173213
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TUBB8P12
Orthologs
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Genomic context

See TUBB8B in Genome Data Viewer
Location:
18p11.32
Exon count:
8
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 18 NC_000018.10 (47085..73539, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 18 NC_000018.9 (47221..49557, complement)

Chromosome 18 - NC_000018.10Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2564 Neighboring gene uncharacterized LOC105371950 Neighboring gene interleukin 9 receptor pseudogene 4 Neighboring gene Sharpr-MPRA regulatory region 10972

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Homology

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables GTP binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables GTPase activity IEA
Inferred from Electronic Annotation
more info
 
enables structural constituent of cytoskeleton IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in microtubule cytoskeleton organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in extracellular exosome HDA PubMed 
is_active_in microtubule IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
tubulin beta 8B
Names
HSA18p11 beta-tubulin 4Q pseudogene
Tubulin beta-8 chain-like protein LOC260334
tubulin beta 8 pseudogene 12

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001358689.2NP_001345618.1  tubulin beta 8B isoform 1

    Status: VALIDATED

    Source sequence(s)
    AP001005
    Consensus CDS
    CCDS86657.1
    Related
    ENSP00000496713.1, ENST00000308911.8
    Conserved Domains (1) summary
    PLN00220
    Location:1427
    PLN00220; tubulin beta chain; Provisional
  2. NM_001389609.1NP_001376538.1  tubulin beta 8B isoform 2

    Status: VALIDATED

    Source sequence(s)
    AP001005
    Conserved Domains (1) summary
    PLN00220
    Location:1355
    PLN00220; tubulin beta chain; Provisional
  3. NM_001389610.1NP_001376539.1  tubulin beta 8B isoform 3

    Status: VALIDATED

    Source sequence(s)
    AP001005
    Conserved Domains (1) summary
    cd02187
    Location:112375
    beta_tubulin; The beta-tubulin family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000018.10 Reference GRCh38.p13 Primary Assembly

    Range
    47085..73539 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024451148.1XP_024306916.1  tubulin beta 8B isoform X5

    Conserved Domains (1) summary
    cd02187
    Location:10273
    beta_tubulin; The beta-tubulin family
  2. XM_024451143.1XP_024306911.1  tubulin beta 8B isoform X1

    Conserved Domains (1) summary
    cd02187
    Location:112375
    beta_tubulin; The beta-tubulin family
  3. XM_024451144.1XP_024306912.1  tubulin beta 8B isoform X1

    Conserved Domains (1) summary
    cd02187
    Location:112375
    beta_tubulin; The beta-tubulin family
  4. XM_024451145.1XP_024306913.1  tubulin beta 8B isoform X2

    Conserved Domains (1) summary
    PLN00220
    Location:1355
    PLN00220; tubulin beta chain; Provisional
  5. XM_024451146.1XP_024306914.1  tubulin beta 8B isoform X3

    Conserved Domains (1) summary
    cd02187
    Location:13346
    beta_tubulin; The beta-tubulin family
  6. XM_024451147.1XP_024306915.1  tubulin beta 8B isoform X4

    Conserved Domains (1) summary
    PTZ00010
    Location:1311
    PTZ00010; tubulin beta chain; Provisional

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NG_002339.3: Suppressed sequence

    Description
    NG_002339.3: This RefSeq was removed because it is currently thought that this locus produces a protein.
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