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ATRNL1 attractin like 1 [ Homo sapiens (human) ]

Gene ID: 26033, updated on 6-May-2021

Summary

Official Symbol
ATRNL1provided by HGNC
Official Full Name
attractin like 1provided by HGNC
Primary source
HGNC:HGNC:29063
See related
Ensembl:ENSG00000107518 MIM:612869
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ALP; bA338L11.1; bA454H24.1
Expression
Biased expression in brain (RPKM 4.2), ovary (RPKM 1.8) and 5 other tissues See more
Orthologs
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Genomic context

See ATRNL1 in Genome Data Viewer
Location:
10q25.3
Exon count:
38
Annotation release Status Assembly Chr Location
109.20210226 current GRCh38.p13 (GCF_000001405.39) 10 NC_000010.11 (115093365..115948999)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (116853124..117708510)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984272 Neighboring gene uncharacterized LOC105378496 Neighboring gene uncharacterized LOC105378497 Neighboring gene N-terminal asparagine amidase pseudogene 1 Neighboring gene GDNF family receptor alpha 1 Neighboring gene uncharacterized LOC107984273 Neighboring gene small nucleolar RNA, C/D box 158

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Whole genome association scan for genetic polymorphisms influencing information processing speed.
GeneReviews: Not available

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ45344, KIAA0534

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carbohydrate binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in G protein-coupled receptor signaling pathway IEA
Inferred from Electronic Annotation
more info
 
involved_in animal organ morphogenesis IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in cell migration IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in substrate adhesion-dependent cell spreading IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in tissue development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
is_active_in basement membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001276282.4NP_001263211.1  attractin-like protein 1 isoform 2 precursor

    See identical proteins and their annotated locations for NP_001263211.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) has its transcription extend past a splice site that is used in variant 1 and which results in a novel 3' coding region and 3' UTR, compared to variant 1. It encodes isoform 2 which is shorter and has a distinct C-terminus, compared to isoform 1.
    Source sequence(s)
    BC029592, BC139916
    Consensus CDS
    CCDS73204.1
    UniProtKB/Swiss-Prot
    Q5VV63
    UniProtKB/TrEMBL
    Q4G0Y2
    Related
    ENSP00000476902.2, ENST00000609571.5
    Conserved Domains (4) summary
    cd00041
    Location:93208
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    sd00038
    Location:305352
    Kelch; KELCH repeat [structural motif]
    pfam13854
    Location:352392
    Kelch_5; Kelch motif
    cl19567
    Location:235280
    DSL; Delta serrate ligand
  2. NM_207303.4NP_997186.1  attractin-like protein 1 isoform 1 precursor

    See identical proteins and their annotated locations for NP_997186.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC022542, AY442317, BC035157
    Consensus CDS
    CCDS7592.1
    UniProtKB/Swiss-Prot
    Q5VV63
    UniProtKB/TrEMBL
    Q4G0Y2
    Related
    ENSP00000347152.3, ENST00000355044.8
    Conserved Domains (8) summary
    cd03597
    Location:748874
    CLECT_attractin_like; C-type lectin-like domain (CTLD) of the type found in human and mouse attractin (AtrN) and attractin-like protein (ALP)
    cd00041
    Location:93208
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00055
    Location:10131058
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    sd00038
    Location:521574
    Kelch; KELCH repeat [structural motif]
    pfam01437
    Location:889938
    PSI; Plexin repeat
    pfam13418
    Location:468514
    Kelch_4; Galactose oxidase, central domain
    pfam13854
    Location:352392
    Kelch_5; Kelch motif
    cl19567
    Location:235280
    DSL; Delta serrate ligand

RNA

  1. NR_074088.3 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) has multiple differences, compared to variant 1, at its 5' and 3' ends including having its transcription extend past a splice site that is used in variant 1. This variant is represented as non-coding because the predicted protein does not meet RefSeq quality criteria.
    Source sequence(s)
    BC029592
    Related
    ENST00000616894.1

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210226

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000010.11 Reference GRCh38.p13 Primary Assembly

    Range
    115093365..115948999
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011539587.1XP_011537889.1  attractin-like protein 1 isoform X2

    Conserved Domains (7) summary
    cd03597
    Location:748874
    CLECT_attractin_like; C-type lectin-like domain (CTLD) of the type found in human and mouse attractin (AtrN) and attractin-like protein (ALP)
    cd00041
    Location:93208
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    sd00038
    Location:521574
    Kelch; KELCH repeat [structural motif]
    pfam01437
    Location:889938
    PSI; Plexin repeat
    pfam13418
    Location:468514
    Kelch_4; Galactose oxidase, central domain
    pfam13854
    Location:352392
    Kelch_5; Kelch motif
    cl19567
    Location:235280
    DSL; Delta serrate ligand
  2. XM_017016035.2XP_016871524.1  attractin-like protein 1 isoform X1

  3. XM_011539589.2XP_011537891.1  attractin-like protein 1 isoform X4

    Conserved Domains (8) summary
    cd03597
    Location:748874
    CLECT_attractin_like; C-type lectin-like domain (CTLD) of the type found in human and mouse attractin (AtrN) and attractin-like protein (ALP)
    cd00041
    Location:93208
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00055
    Location:10131058
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    sd00038
    Location:521574
    Kelch; KELCH repeat [structural motif]
    pfam01437
    Location:889938
    PSI; Plexin repeat
    pfam13418
    Location:468514
    Kelch_4; Galactose oxidase, central domain
    pfam13854
    Location:352392
    Kelch_5; Kelch motif
    cl19567
    Location:235280
    DSL; Delta serrate ligand
  4. XM_017016036.1XP_016871525.1  attractin-like protein 1 isoform X6

  5. XM_011539588.2XP_011537890.1  attractin-like protein 1 isoform X3

    Conserved Domains (8) summary
    cd03597
    Location:681807
    CLECT_attractin_like; C-type lectin-like domain (CTLD) of the type found in human and mouse attractin (AtrN) and attractin-like protein (ALP)
    cd00041
    Location:29141
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cd00055
    Location:946991
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    sd00038
    Location:454507
    Kelch; KELCH repeat [structural motif]
    pfam01437
    Location:822871
    PSI; Plexin repeat
    pfam13418
    Location:401447
    Kelch_4; Galactose oxidase, central domain
    pfam13854
    Location:285325
    Kelch_5; Kelch motif
    cl19567
    Location:168213
    DSL; Delta serrate ligand
  6. XM_011539590.2XP_011537892.1  attractin-like protein 1 isoform X5

    See identical proteins and their annotated locations for XP_011537892.1

    Conserved Domains (8) summary
    cd03597
    Location:602728
    CLECT_attractin_like; C-type lectin-like domain (CTLD) of the type found in human and mouse attractin (AtrN) and attractin-like protein (ALP)
    cd00055
    Location:867912
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    sd00038
    Location:375428
    Kelch; KELCH repeat [structural motif]
    pfam01437
    Location:743792
    PSI; Plexin repeat
    pfam13418
    Location:322368
    Kelch_4; Galactose oxidase, central domain
    pfam13854
    Location:206246
    Kelch_5; Kelch motif
    cl00049
    Location:362
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cl19567
    Location:89134
    DSL; Delta serrate ligand
  7. XM_017016038.1XP_016871527.1  attractin-like protein 1 isoform X8

  8. XM_011539591.2XP_011537893.1  attractin-like protein 1 isoform X5

    See identical proteins and their annotated locations for XP_011537893.1

    Conserved Domains (8) summary
    cd03597
    Location:602728
    CLECT_attractin_like; C-type lectin-like domain (CTLD) of the type found in human and mouse attractin (AtrN) and attractin-like protein (ALP)
    cd00055
    Location:867912
    EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...
    sd00038
    Location:375428
    Kelch; KELCH repeat [structural motif]
    pfam01437
    Location:743792
    PSI; Plexin repeat
    pfam13418
    Location:322368
    Kelch_4; Galactose oxidase, central domain
    pfam13854
    Location:206246
    Kelch_5; Kelch motif
    cl00049
    Location:362
    CUB; CUB domain; extracellular domain; present in proteins mostly known to be involved in development; not found in prokaryotes, plants and yeast.
    cl19567
    Location:89134
    DSL; Delta serrate ligand
  9. XM_017016037.1XP_016871526.1  attractin-like protein 1 isoform X7

  10. XM_017016039.2XP_016871528.1  attractin-like protein 1 isoform X9

  11. XM_017016040.1XP_016871529.1  attractin-like protein 1 isoform X10

RNA

  1. XR_945653.2 RNA Sequence

  2. XR_001747080.1 RNA Sequence

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