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Homez homeobox and leucine zipper encoding [ Rattus norvegicus (Norway rat) ]

Gene ID: 260325, updated on 5-Sep-2025
Official Symbol
Homezprovided by RGD
Official Full Name
homeobox and leucine zipper encodingprovided by RGD
Primary source
RGD:628904
See related
Ensembl:ENSRNOG00000014887 AllianceGenome:RGD:628904
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Rattus norvegicus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary
Predicted to enable DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in cytosol; nucleolus; and nucleoplasm. Predicted to be active in nucleus. Orthologous to human HOMEZ (homeobox and leucine zipper encoding). [provided by Alliance of Genome Resources, Jul 2025]
Expression
Biased expression in Testes (RPKM 71.1), Kidney (RPKM 28.3) and 9 other tissues See more
Orthologs
human mouse all
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See Homez in Genome Data Viewer
Location:
15p13
Exon count:
4
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (32292897..32309564, complement)
RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (28321633..28339486, complement)
106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (33510454..33528018, complement)

Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene ring finger protein 212B Neighboring gene U6 spliceosomal RNA Neighboring gene WW domain-binding protein 11-like Neighboring gene protein phosphatase 1, regulatory subunit 3E Neighboring gene Bcl2-like 2

Go to nucleotide: Graphics FASTA GenBank

  • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
  • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
  • BioProject: PRJNA238328
  • Publication: PMID 24510058
  • Analysis date: Mon Jun 6 17:44:12 2016

Related articles in PubMed

  1. Homez, a homeobox leucine zipper gene specific to the vertebrate lineage. Bayarsaihan D, et al. Proc Natl Acad Sci U S A, 2003 Sep 2. PMID 12925734, Free PMC Article
  2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
  3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Homez is a homeobox leucine zipper gene specific to the vertebrate lineage.
    Title: Homez, a homeobox leucine zipper gene specific to the vertebrate lineage.
Submit: New GeneRIF Correction

Homology

Clone Names

  • MGC93137, MGC105306

Gene Ontology Provided by RGD

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
enables DNA binding ISO
Inferred from Sequence Orthology
more info
  
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus ISO
Inferred from Sequence Orthology
more info
  
Preferred Names
homeobox and leucine zipper protein Homez
Names
homeodomain leucine zipper-containing factor
homeodomain leucine zipper-encoding
homeodomain-leucine zipper protein HOMEZ

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_152849.2 → NP_690062.3  homeobox and leucine zipper protein Homez

    See identical proteins and their annotated locations for NP_690062.3

    Status: VALIDATED

    Source sequence(s)
    BC084701
    UniProtKB/TrEMBL
    A0A8I6ABU6, F8WFQ4
    Conserved Domains (2) summary
    cd00086
    Location:346 → 403
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam11569
    Location:448 → 495
    Homez; Homeodomain leucine-zipper encoding, Homez

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

  1. NC_086033.1 Reference GRCr8

    Range
    32292897..32309564 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_063274032.1 → XP_063130102.1  homeobox and leucine zipper protein Homez isoform X3

    UniProtKB/TrEMBL
    A0A8I6ABU6
    Related
    ENSRNOP00000019979.6, ENSRNOT00000019979.6

  2. XM_006251930.5 → XP_006251992.3  homeobox and leucine zipper protein Homez isoform X1

    UniProtKB/Swiss-Prot
    Q8K3E9
    UniProtKB/TrEMBL
    A6KGW4, Q5XFX1
    Conserved Domains (2) summary
    cd00086
    Location:327 → 384
    homeodomain; Homeodomain; DNA binding domains involved in the transcriptional regulation of key eukaryotic developmental processes; may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner.
    pfam11569
    Location:429 → 475
    Homez; Homeodomain leucine-zipper encoding, Homez

  3. XM_008770663.4 → XP_008768885.2  homeobox and leucine zipper protein Homez isoform X2

    UniProtKB/Swiss-Prot
    Q8K3E9
    UniProtKB/TrEMBL
    A6KGW4
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8K3E9.1 GenPept UniProtKB/Swiss-Prot:Q8K3E9

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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