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Nav3 neuron navigator 3 [ Mus musculus (house mouse) ]

Gene ID: 260315, updated on 30-Apr-2024

Summary

Official Symbol
Nav3provided by MGI
Official Full Name
neuron navigator 3provided by MGI
Primary source
MGI:MGI:2183703
See related
Ensembl:ENSMUSG00000020181 AllianceGenome:MGI:2183703
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
POMFIL1; unc53H3; Pomfil1p; mKIAA0938; 4732483H20Rik; 9630020C08Rik
Summary
Predicted to enable microtubule binding activity. Predicted to be involved in several processes, including negative regulation of cell migration; negative regulation of interleukin-2 production; and regulation of microtubule polymerization or depolymerization. Located in nuclear envelope. Is expressed in central nervous system; liver; lung; notochord; and retina layer. Orthologous to human NAV3 (neuron navigator 3). [provided by Alliance of Genome Resources, Apr 2022]
Expression
Biased expression in CNS E18 (RPKM 6.2), cortex adult (RPKM 6.1) and 12 other tissues See more
Orthologs
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Genomic context

See Nav3 in Genome Data Viewer
Location:
10 D1; 10 57.18 cM
Exon count:
45
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (109517121..110292148, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (109681260..110455722, complement)

Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 23041 Neighboring gene STARR-seq mESC enhancer starr_27835 Neighboring gene STARR-seq mESC enhancer starr_27836 Neighboring gene predicted gene, 40757 Neighboring gene STARR-seq mESC enhancer starr_27839 Neighboring gene STARR-seq mESC enhancer starr_27840 Neighboring gene STARR-seq mESC enhancer starr_27841 Neighboring gene STARR-seq mESC enhancer starr_27843 Neighboring gene STARR-seq mESC enhancer starr_27842 Neighboring gene predicted gene, 47340 Neighboring gene STARR-seq mESC enhancer starr_27844 Neighboring gene STARR-seq mESC enhancer starr_27845 Neighboring gene STARR-seq mESC enhancer starr_27846 Neighboring gene RIKEN cDNA 9230102K24 gene Neighboring gene STARR-seq mESC enhancer starr_27847 Neighboring gene STARR-seq mESC enhancer starr_27848 Neighboring gene predicted gene, 36751

Genomic regions, transcripts, and products

Expression

  • Project title: Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Variation

Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)
  • Endonuclease-mediated (1) 

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
 
enables ATP hydrolysis activity IEA
Inferred from Electronic Annotation
more info
 
enables microtubule binding ISO
Inferred from Sequence Orthology
more info
 
Process Evidence Code Pubs
involved_in negative regulation of cell migration ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of interleukin-2 production ISO
Inferred from Sequence Orthology
more info
 
involved_in negative regulation of microtubule depolymerization ISO
Inferred from Sequence Orthology
more info
 
involved_in nervous system development IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in neurogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of microtubule polymerization ISO
Inferred from Sequence Orthology
more info
 
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
 
colocalizes_with microtubule end ISO
Inferred from Sequence Orthology
more info
 
located_in nuclear envelope IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
neuron navigator 3
Names
pore membrane and/or filament-interacting-like protein 1
steerin 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081035.2NP_001074504.1  neuron navigator 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC100120, AC122011, AC129336
    Consensus CDS
    CCDS36054.1
    UniProtKB/TrEMBL
    E9QMF5
    Related
    ENSMUSP00000032719.8, ENSMUST00000032719.15
    Conserved Domains (5) summary
    cd00009
    Location:20332113
    AAA; The AAA+ (ATPases Associated with a wide variety of cellular Activities) superfamily represents an ancient group of ATPases belonging to the ASCE (for additional strand, catalytic E) division of the P-loop NTPase fold. The ASCE division also includes ABC, ...
    smart00382
    Location:20302150
    AAA; ATPases associated with a variety of cellular activities
    cd00014
    Location:81182
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    pfam15898
    Location:17751838
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
    cl21455
    Location:20172047
    P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases
  2. NM_001368815.1NP_001355744.1  neuron navigator 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC100120, AC122011, AC129336
    UniProtKB/Swiss-Prot
    Q80TN7
    Conserved Domains (6) summary
    smart00382
    Location:20232143
    AAA; ATPases associated with a variety of cellular activities
    PHA03307
    Location:9791294
    PHA03307; transcriptional regulator ICP4; Provisional
    cd00014
    Location:81182
    CH; Calponin homology domain; actin-binding domain which may be present as a single copy or in tandem repeats (which increases binding affinity). The CH domain is found in cytoskeletal and signal transduction proteins, including actin-binding proteins like ...
    TIGR04211
    Location:15731649
    SH3_and_anchor; SH3 domain protein
    pfam05109
    Location:204582
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam15898
    Location:17681831
    PRKG1_interact; cGMP-dependent protein kinase interacting domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000076.7 Reference GRCm39 C57BL/6J

    Range
    109517121..110292148 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036155787.1XP_036011680.1  neuron navigator 3 isoform X4

    UniProtKB/TrEMBL
    A0A668KM70
    Conserved Domains (5) summary
    smart00382
    Location:19732093
    AAA; ATPases associated with a variety of cellular activities
    PHA03307
    Location:9221237
    PHA03307; transcriptional regulator ICP4; Provisional
    COG1196
    Location:15191779
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam05109
    Location:147525
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cd21286
    Location:24126
    CH_NAV3; calponin homology (CH) domain found in neuron navigator 3
  2. XM_006513680.4XP_006513743.1  neuron navigator 3 isoform X8

    Conserved Domains (7) summary
    smart00382
    Location:18531973
    AAA; ATPases associated with a variety of cellular activities
    PHA03307
    Location:9791297
    PHA03307; transcriptional regulator ICP4; Provisional
    COG1196
    Location:13991659
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR04211
    Location:13961472
    SH3_and_anchor; SH3 domain protein
    pfam05109
    Location:204582
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00307
    Location:81182
    CH; Calponin homology (CH) domain
    pfam15898
    Location:16071661
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
  3. XM_006513679.4XP_006513742.1  neuron navigator 3 isoform X7

    Conserved Domains (7) summary
    smart00382
    Location:18671987
    AAA; ATPases associated with a variety of cellular activities
    PHA03307
    Location:9791311
    PHA03307; transcriptional regulator ICP4; Provisional
    COG1196
    Location:14131673
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR04211
    Location:14101486
    SH3_and_anchor; SH3 domain protein
    pfam05109
    Location:204582
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00307
    Location:81182
    CH; Calponin homology (CH) domain
    pfam15898
    Location:16211675
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
  4. XM_006513676.4XP_006513739.1  neuron navigator 3 isoform X1

    Conserved Domains (7) summary
    smart00382
    Location:20162136
    AAA; ATPases associated with a variety of cellular activities
    PHA03307
    Location:9791294
    PHA03307; transcriptional regulator ICP4; Provisional
    COG1196
    Location:15621822
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR04211
    Location:15591635
    SH3_and_anchor; SH3 domain protein
    pfam05109
    Location:204582
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00307
    Location:81182
    CH; Calponin homology (CH) domain
    pfam15898
    Location:17701824
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
  5. XM_006513677.4XP_006513740.1  neuron navigator 3 isoform X3

    Conserved Domains (6) summary
    smart00382
    Location:20072127
    AAA; ATPases associated with a variety of cellular activities
    PHA03307
    Location:9561271
    PHA03307; transcriptional regulator ICP4; Provisional
    COG1196
    Location:15531813
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    TIGR04211
    Location:15501626
    SH3_and_anchor; SH3 domain protein
    pfam05109
    Location:262559
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00307
    Location:81182
    CH; Calponin homology (CH) domain
  6. XM_017313948.3XP_017169437.1  neuron navigator 3 isoform X10

    UniProtKB/TrEMBL
    A0A571BDN3
    Related
    ENSMUSP00000158790.2, ENSMUST00000238286.2
    Conserved Domains (6) summary
    smart00382
    Location:15151635
    AAA; ATPases associated with a variety of cellular activities
    PHA03307
    Location:478793
    PHA03307; transcriptional regulator ICP4; Provisional
    TIGR02169
    Location:10501321
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    TIGR04211
    Location:10581134
    SH3_and_anchor; SH3 domain protein
    pfam05109
    Location:659996
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam15898
    Location:12691323
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
  7. XM_006513681.5XP_006513744.1  neuron navigator 3 isoform X9

    UniProtKB/TrEMBL
    A0A571BDN3
    Conserved Domains (6) summary
    smart00382
    Location:15291649
    AAA; ATPases associated with a variety of cellular activities
    PHA03307
    Location:478793
    PHA03307; transcriptional regulator ICP4; Provisional
    TIGR02169
    Location:10641335
    SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    TIGR04211
    Location:10721148
    SH3_and_anchor; SH3 domain protein
    pfam05109
    Location:6591010
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam15898
    Location:12831337
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
  8. XM_036155788.1XP_036011681.1  neuron navigator 3 isoform X5

    Conserved Domains (5) summary
    smart00382
    Location:19502070
    AAA; ATPases associated with a variety of cellular activities
    PHA03307
    Location:8991214
    PHA03307; transcriptional regulator ICP4; Provisional
    COG1196
    Location:14961756
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam05109
    Location:205502
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cd21286
    Location:24126
    CH_NAV3; calponin homology (CH) domain found in neuron navigator 3
  9. XM_017313946.3XP_017169435.1  neuron navigator 3 isoform X4

    UniProtKB/TrEMBL
    A0A668KM70
    Related
    ENSMUSP00000159239.2, ENSMUST00000239301.2
    Conserved Domains (5) summary
    smart00382
    Location:19732093
    AAA; ATPases associated with a variety of cellular activities
    PHA03307
    Location:9221237
    PHA03307; transcriptional regulator ICP4; Provisional
    COG1196
    Location:15191779
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam05109
    Location:147525
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cd21286
    Location:24126
    CH_NAV3; calponin homology (CH) domain found in neuron navigator 3
  10. XM_017313945.2XP_017169434.1  neuron navigator 3 isoform X2

    Conserved Domains (6) summary
    smart00382
    Location:20092129
    AAA; ATPases associated with a variety of cellular activities
    PHA03307
    Location:9791294
    PHA03307; transcriptional regulator ICP4; Provisional
    TIGR04211
    Location:15591635
    SH3_and_anchor; SH3 domain protein
    pfam05109
    Location:204582
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    pfam00307
    Location:81182
    CH; Calponin homology (CH) domain
    pfam15898
    Location:17631817
    PRKG1_interact; cGMP-dependent protein kinase interacting domain
  11. XM_036155789.1XP_036011682.1  neuron navigator 3 isoform X6

    Conserved Domains (5) summary
    smart00382
    Location:18932013
    AAA; ATPases associated with a variety of cellular activities
    PHA03307
    Location:8421157
    PHA03307; transcriptional regulator ICP4; Provisional
    COG1196
    Location:14391699
    Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
    pfam05109
    Location:67445
    Herpes_BLLF1; Herpes virus major outer envelope glycoprotein (BLLF1)
    cl00030
    Location:146
    CH_SF; calponin homology (CH) domain superfamily

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_177797.2: Suppressed sequence

    Description
    NM_177797.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.