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OSBPL3 oxysterol binding protein like 3 [ Homo sapiens (human) ]

Gene ID: 26031, updated on 7-Oct-2018

Summary

Official Symbol
OSBPL3provided by HGNC
Official Full Name
oxysterol binding protein like 3provided by HGNC
Primary source
HGNC:HGNC:16370
See related
Ensembl:ENSG00000070882 MIM:606732; Vega:OTTHUMG00000023277
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ORP3; ORP-3; OSBP3
Summary
This gene encodes a member of the oxysterol-binding protein (OSBP) family, a group of intracellular lipid receptors. Most members contain an N-terminal pleckstrin homology domain and a highly conserved C-terminal OSBP-like sterol-binding domain. The encoded protein is involved in the regulation of cell adhesion and organization of the actin cytoskeleton. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Expression
Ubiquitous expression in lymph node (RPKM 4.4), urinary bladder (RPKM 4.1) and 23 other tissues See more
Orthologs

Genomic context

See OSBPL3 in Genome Data Viewer
Location:
7p15.3
Exon count:
26
Annotation release Status Assembly Chr Location
109 current GRCh38.p12 (GCF_000001405.38) 7 NC_000007.14 (24796537..24980218, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (24836159..25019818, complement)

Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene gasdermin E Neighboring gene uncharacterized LOC107986779 Neighboring gene small nuclear ribonucleoprotein polypeptide C pseudogene 19 Neighboring gene chromosome 7 open reading frame 31 Neighboring gene cytochrome c, somatic

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Jun 15 11:32:44 2016

Bibliography

GeneRIFs: Gene References Into FunctionsWhat's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of oxysterol binding protein-like 3 (OSBPL3) by siRNA inhibits the early stages of HIV-1 replication in 293T cells infected with VSV-G pseudotyped HIV-1 PubMed

Protein interactions

Protein Gene Interaction Pubs
Pol gag-pol HIV-1 Pol is identified to have a physical interaction with oxysterol binding protein-like 3 (OSBPL3) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed
retropepsin gag-pol HIV-1 PR is identified to have a physical interaction with oxysterol binding protein-like 3 (OSBPL3) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Pathways from BioSystems

  • Bile acid and bile salt metabolism, organism-specific biosystem (from REACTOME)
    Bile acid and bile salt metabolism, organism-specific biosystemIn a healthy adult human, about 500 mg of cholesterol is converted to bile salts daily. Newly synthesized bile salts are secreted into the bile and released into the small intestine where they emulsi...
  • Metabolism, organism-specific biosystem (from REACTOME)
    Metabolism, organism-specific biosystemMetabolic processes in human cells generate energy through the oxidation of molecules consumed in the diet and mediate the synthesis of diverse essential molecules not taken in the diet as well as th...
  • Metabolism of lipids and lipoproteins, organism-specific biosystem (from REACTOME)
    Metabolism of lipids and lipoproteins, organism-specific biosystemLipids are hydrophobic but otherwise chemically diverse molecules that play a wide variety of roles in human biology. They include ketone bodies, fatty acids, triacylglycerols, phospholipids and sphi...
  • Synthesis of bile acids and bile salts, organism-specific biosystem (from REACTOME)
    Synthesis of bile acids and bile salts, organism-specific biosystemIn a healthy adult human, about 500 mg of cholesterol is converted to bile salts daily (Russell 2003). The major pathway for bile salt synthesis in the liver begins with the conversion of cholesterol...

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • KIAA0704, MGC21526, DKFZp667P1518

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cholesterol binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cholesterol binding IDA
Inferred from Direct Assay
more info
PubMed 
lipid binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
sterol binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sterol transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
sterol transporter activity TAS
Traceable Author Statement
more info
 
Process Evidence Code Pubs
bile acid biosynthetic process TAS
Traceable Author Statement
more info
 
sterol transport IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
PubMed 
cytosol TAS
Traceable Author Statement
more info
 
endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
 
filopodium tip IEA
Inferred from Electronic Annotation
more info
 
intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
membrane HDA PubMed 
membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear membrane IDA
Inferred from Direct Assay
more info
PubMed 
perinuclear endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
perinuclear endoplasmic reticulum IDA
Inferred from Direct Assay
more info
PubMed 
plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
oxysterol-binding protein-related protein 3
Names
OSBP-related protein 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015550.3NP_056365.1  oxysterol-binding protein-related protein 3 isoform a

    See identical proteins and their annotated locations for NP_056365.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longest isoform (a). Isoform a contains a pleckstrin homology domain and a sterol-binding domain. It is also known as isoform 1a.
    Source sequence(s)
    AB014604, AC003093, AW241639, AY008372, DR003143
    Consensus CDS
    CCDS5390.1
    UniProtKB/Swiss-Prot
    Q9H4L5
    Related
    ENSP00000315410.2, OTTHUMP00000122489, ENST00000313367.6, OTTHUMT00000214085
    Conserved Domains (3) summary
    cd13287
    Location:31153
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam00169
    Location:52142
    PH; PH domain
    pfam01237
    Location:527861
    Oxysterol_BP; Oxysterol-binding protein
  2. NM_145320.2NP_663160.1  oxysterol-binding protein-related protein 3 isoform b

    See identical proteins and their annotated locations for NP_663160.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an in-frame exon compared to variant 1, resulting in a shorter isoform (b) compared to isoform a. Isoform b contains a pleckstrin homology domain and a sterol-binding domain. It is also known as isoform 1b.
    Source sequence(s)
    AB014604, AC003093, AF323727, AF491782, AW241639, AY008372
    Consensus CDS
    CCDS5391.1
    UniProtKB/Swiss-Prot
    Q9H4L5
    Related
    ENSP00000379708.1, OTTHUMP00000122490, ENST00000396431.5, OTTHUMT00000214086
    Conserved Domains (3) summary
    cd13287
    Location:31153
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam00169
    Location:52142
    PH; PH domain
    pfam01237
    Location:496830
    Oxysterol_BP; Oxysterol-binding protein
  3. NM_145321.2NP_663161.1  oxysterol-binding protein-related protein 3 isoform c

    See identical proteins and their annotated locations for NP_663161.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) lacks an in-frame exon compared to variant 1, resulting in a shorter isoform (c) compared to isoform a. Isoform c contains a pleckstrin homology domain and a sterol-binding domain. It is also known as isoform 1c.
    Source sequence(s)
    AB014604, AC003093, AF323727, AF491783, AW241639, AY008372
    Consensus CDS
    CCDS5392.1
    UniProtKB/Swiss-Prot
    Q9H4L5
    Related
    ENSP00000379706.1, OTTHUMP00000122491, ENST00000396429.5, OTTHUMT00000214087
    Conserved Domains (3) summary
    cd13287
    Location:31153
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam00169
    Location:52142
    PH; PH domain
    pfam01237
    Location:491825
    Oxysterol_BP; Oxysterol-binding protein
  4. NM_145322.2NP_663162.1  oxysterol-binding protein-related protein 3 isoform d

    See identical proteins and their annotated locations for NP_663162.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) lacks two in-frame exons compared to variant 1, resulting in a shorter isoform (d) compared to isoform a. Isoform d contains a pleckstrin homology domain and a sterol-binding domain. It is also known as isoform 1d.
    Source sequence(s)
    AB014604, AC003093, AF323727, AF491784, AW241639, AY008372
    Consensus CDS
    CCDS47564.1
    UniProtKB/Swiss-Prot
    Q9H4L5
    Related
    ENSP00000386953.1, OTTHUMP00000202019, ENST00000409069.5, OTTHUMT00000326877
    Conserved Domains (3) summary
    cd13287
    Location:31153
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam00169
    Location:52142
    PH; PH domain
    pfam01237
    Location:460794
    Oxysterol_BP; Oxysterol-binding protein

RNA

  1. NR_104111.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB014604, AC003093, AF323727, AF491785, AW241639, AY008372
  2. NR_104112.1 RNA Sequence

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6) uses an alternate splice site in an internal exon and lacks an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AB014604, AC003093, AF323727, AF491786, AW241639, AY008372

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p12 Primary Assembly

Genomic

  1. NC_000007.14 Reference GRCh38.p12 Primary Assembly

    Range
    24796537..24980218 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006715683.3XP_006715746.1  oxysterol-binding protein-related protein 3 isoform X5

    See identical proteins and their annotated locations for XP_006715746.1

    UniProtKB/Swiss-Prot
    Q9H4L5
    Conserved Domains (3) summary
    cd13287
    Location:31153
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam00169
    Location:52142
    PH; PH domain
    pfam01237
    Location:460794
    Oxysterol_BP; Oxysterol-binding protein
  2. XM_006715682.3XP_006715745.1  oxysterol-binding protein-related protein 3 isoform X3

    See identical proteins and their annotated locations for XP_006715745.1

    UniProtKB/Swiss-Prot
    Q9H4L5
    Conserved Domains (3) summary
    cd13287
    Location:31153
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam00169
    Location:52142
    PH; PH domain
    pfam01237
    Location:491825
    Oxysterol_BP; Oxysterol-binding protein
  3. XM_006715684.4XP_006715747.1  oxysterol-binding protein-related protein 3 isoform X7

    Conserved Domains (1) summary
    pfam01237
    Location:174508
    Oxysterol_BP; Oxysterol-binding protein
  4. XM_006715681.3XP_006715744.1  oxysterol-binding protein-related protein 3 isoform X2

    See identical proteins and their annotated locations for XP_006715744.1

    UniProtKB/Swiss-Prot
    Q9H4L5
    Conserved Domains (3) summary
    cd13287
    Location:31153
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam00169
    Location:52142
    PH; PH domain
    pfam01237
    Location:496830
    Oxysterol_BP; Oxysterol-binding protein
  5. XM_017011948.1XP_016867437.1  oxysterol-binding protein-related protein 3 isoform X4

    Conserved Domains (3) summary
    cd13287
    Location:1109
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam00169
    Location:898
    PH; PH domain
    pfam01237
    Location:483817
    Oxysterol_BP; Oxysterol-binding protein
  6. XM_017011949.1XP_016867438.1  oxysterol-binding protein-related protein 3 isoform X6

  7. XM_011515259.2XP_011513561.1  oxysterol-binding protein-related protein 3 isoform X4

    See identical proteins and their annotated locations for XP_011513561.1

    Conserved Domains (3) summary
    cd13287
    Location:1109
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam00169
    Location:898
    PH; PH domain
    pfam01237
    Location:483817
    Oxysterol_BP; Oxysterol-binding protein
  8. XM_005249698.3XP_005249755.1  oxysterol-binding protein-related protein 3 isoform X1

    See identical proteins and their annotated locations for XP_005249755.1

    UniProtKB/Swiss-Prot
    Q9H4L5
    Conserved Domains (3) summary
    cd13287
    Location:31153
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam00169
    Location:52142
    PH; PH domain
    pfam01237
    Location:527861
    Oxysterol_BP; Oxysterol-binding protein
  9. XM_011515258.2XP_011513560.1  oxysterol-binding protein-related protein 3 isoform X1

    See identical proteins and their annotated locations for XP_011513560.1

    UniProtKB/Swiss-Prot
    Q9H4L5
    Conserved Domains (3) summary
    cd13287
    Location:31153
    PH_ORP3_ORP6_ORP7; Human Oxysterol binding protein related proteins 3, 6, and 7 Pleckstrin homology (PH) domain
    pfam00169
    Location:52142
    PH; PH domain
    pfam01237
    Location:527861
    Oxysterol_BP; Oxysterol-binding protein

RNA

  1. XR_428075.3 RNA Sequence

  2. XR_001744620.1 RNA Sequence

  3. XR_428073.3 RNA Sequence

  4. XR_428074.3 RNA Sequence

  5. XR_926929.1 RNA Sequence

  6. XR_926927.2 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_145323.1: Suppressed sequence

    Description
    NM_145323.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
  2. NM_145324.1: Suppressed sequence

    Description
    NM_145324.1: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
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