Format

Send to:

Choose Destination

PLEKHG3 pleckstrin homology and RhoGEF domain containing G3 [ Homo sapiens (human) ]

Gene ID: 26030, updated on 4-Jun-2020

Summary

Official Symbol
PLEKHG3provided by HGNC
Official Full Name
pleckstrin homology and RhoGEF domain containing G3provided by HGNC
Primary source
HGNC:HGNC:20364
See related
Ensembl:ENSG00000126822 MIM:617940
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ARHGEF43; KIAA0599
Expression
Ubiquitous expression in endometrium (RPKM 8.9), kidney (RPKM 8.6) and 25 other tissues See more
Orthologs

Genomic context

See PLEKHG3 in Genome Data Viewer
Location:
14q23.3
Exon count:
25
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 14 NC_000014.9 (64704128..64750249)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (65171132..65213623)

Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene protein phosphatase 1 regulatory subunit 36 Neighboring gene nucleoporin 50 pseudogene 1 Neighboring gene spectrin beta, erythrocytic Neighboring gene microRNA 7855 Neighboring gene uncharacterized LOC105370534

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC156299, MGC156300

Gene Ontology Provided by GOA

Function Evidence Code Pubs
Rho guanyl-nucleotide exchange factor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
pleckstrin homology domain-containing family G member 3
Names
PH domain-containing family G member 3
pleckstrin homology domain containing, family G (with RhoGef domain) member 3
pleckstrin homology domain containing, family G, member 3

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308147.2NP_001295076.1  pleckstrin homology domain-containing family G member 3

    See identical proteins and their annotated locations for NP_001295076.1

    Status: VALIDATED

    Source sequence(s)
    AL121774, BC129952, BC129953, BU681724, BX248779, CN284264, HY057390
    Consensus CDS
    CCDS76690.1
    UniProtKB/Swiss-Prot
    A1L390
    Related
    ENSP00000247226.8, ENST00000247226.13
    Conserved Domains (2) summary
    cd13243
    Location:253396
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00621
    Location:97270
    RhoGEF; RhoGEF domain

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000014.9 Reference GRCh38.p13 Primary Assembly

    Range
    64704128..64750249
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_011536628.3XP_011534930.1  pleckstrin homology domain-containing family G member 3 isoform X3

    See identical proteins and their annotated locations for XP_011534930.1

    Conserved Domains (3) summary
    cd13243
    Location:253396
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00169
    Location:317393
    PH; PH domain
    pfam00621
    Location:97271
    RhoGEF; RhoGEF domain
  2. XM_011536625.3XP_011534927.1  pleckstrin homology domain-containing family G member 3 isoform X1

    Conserved Domains (3) summary
    cd13243
    Location:253396
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00169
    Location:317393
    PH; PH domain
    pfam00621
    Location:97271
    RhoGEF; RhoGEF domain
  3. XM_017021154.2XP_016876643.1  pleckstrin homology domain-containing family G member 3 isoform X2

    Conserved Domains (3) summary
    cd13243
    Location:253396
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00169
    Location:317393
    PH; PH domain
    pfam00621
    Location:97271
    RhoGEF; RhoGEF domain
  4. XM_011536629.3XP_011534931.1  pleckstrin homology domain-containing family G member 3 isoform X5

    Conserved Domains (3) summary
    cd13243
    Location:253396
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00169
    Location:317393
    PH; PH domain
    pfam00621
    Location:97271
    RhoGEF; RhoGEF domain
  5. XM_024449528.1XP_024305296.1  pleckstrin homology domain-containing family G member 3 isoform X6

    Related
    ENSP00000378183.2, ENST00000394691.6
    Conserved Domains (2) summary
    cd13243
    Location:253396
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00621
    Location:97270
    RhoGEF; RhoGEF domain
  6. XM_011536627.3XP_011534929.1  pleckstrin homology domain-containing family G member 3 isoform X4

    Conserved Domains (3) summary
    cd13243
    Location:274417
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00169
    Location:338414
    PH; PH domain
    pfam00621
    Location:118292
    RhoGEF; RhoGEF domain
  7. XM_017021157.2XP_016876646.1  pleckstrin homology domain-containing family G member 3 isoform X6

    UniProtKB/Swiss-Prot
    A1L390
    Conserved Domains (2) summary
    cd13243
    Location:253396
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00621
    Location:97270
    RhoGEF; RhoGEF domain
  8. XM_017021155.2XP_016876644.1  pleckstrin homology domain-containing family G member 3 isoform X3

    Conserved Domains (3) summary
    cd13243
    Location:253396
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00169
    Location:317393
    PH; PH domain
    pfam00621
    Location:97271
    RhoGEF; RhoGEF domain
  9. XM_017021156.2XP_016876645.1  pleckstrin homology domain-containing family G member 3 isoform X3

    Conserved Domains (3) summary
    cd13243
    Location:253396
    PH_PLEKHG1_G2_G3; Pleckstrin homology domain-containing family G members 1, 2, and 3 pleckstrin homology (PH) domain
    pfam00169
    Location:317393
    PH; PH domain
    pfam00621
    Location:97271
    RhoGEF; RhoGEF domain
  10. XM_017021158.2XP_016876647.1  pleckstrin homology domain-containing family G member 3 isoform X7

RNA

  1. XR_002957542.1 RNA Sequence

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_015549.1: Suppressed sequence

    Description
    NM_015549.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.
Support Center