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ACOT11 acyl-CoA thioesterase 11 [ Homo sapiens (human) ]

Gene ID: 26027, updated on 18-Aug-2020

Summary

Official Symbol
ACOT11provided by HGNC
Official Full Name
acyl-CoA thioesterase 11provided by HGNC
Primary source
HGNC:HGNC:18156
See related
Ensembl:ENSG00000162390 MIM:606803
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BFIT; THEA; THEM1; STARD14
Summary
This gene encodes a member of the acyl-CoA thioesterase family which catalyse the conversion of activated fatty acids to the corresponding non-esterified fatty acid and coenzyme A. Expression of a mouse homolog in brown adipose tissue is induced by low temperatures and repressed by warm temperatures. Higher levels of expression of the mouse homolog has been found in obesity-resistant mice compared with obesity-prone mice, suggesting a role of acyl-CoA thioesterase 11 in obesity. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]
Expression
Biased expression in kidney (RPKM 35.3), small intestine (RPKM 20.0) and 9 other tissues See more
Orthologs

Genomic context

See ACOT11 in Genome Data Viewer
Location:
1p32.3
Exon count:
18
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (54548228..54639192)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (55007930..55100417)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2784 Neighboring gene transaldolase 1 pseudogene 1 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 63 Neighboring gene family with sequence similarity 151 member A Neighboring gene MROH7-TTC4 readthrough (NMD candidate) Neighboring gene maestro heat like repeat family member 7 Neighboring gene tetratricopeptide repeat domain 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: MROH7

Homology

Clone Names

  • KIAA0707, DKFZp667O1916

Gene Ontology Provided by GOA

Function Evidence Code Pubs
acyl-CoA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acyl-CoA hydrolase activity TAS
Traceable Author Statement
more info
PubMed 
carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
fatty-acyl-CoA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
lipid binding IEA
Inferred from Electronic Annotation
more info
 
long-chain fatty acyl-CoA binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
myristoyl-CoA hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
palmitoyl-CoA hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
acyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
acyl-CoA metabolic process TAS
Traceable Author Statement
more info
 
fatty acid metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
fatty acid metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
intracellular signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
negative regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
response to cold ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
response to temperature stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
cytosol IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytosol IDA
Inferred from Direct Assay
more info
 
cytosol TAS
Traceable Author Statement
more info
 
extracellular exosome HDA PubMed 
mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
acyl-coenzyme A thioesterase 11
Names
START domain containing 14
StAR-related lipid transfer (START) domain containing 14
acyl-CoA thioester hydrolase 11
adipose-associated thioesterase
brown fat-inducible thioesterase
palmitoyl-coenzyme A thioesterase
thioesterase superfamily member 1
thioesterase, adipose associated
NP_056362.1
NP_671517.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015547.4NP_056362.1  acyl-coenzyme A thioesterase 11 isoform 1

    See identical proteins and their annotated locations for NP_056362.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (BFIT1) of this protein.
    Source sequence(s)
    AF416921, AL590093, DA121227
    Consensus CDS
    CCDS592.1
    UniProtKB/Swiss-Prot
    Q8WXI4
    Related
    ENSP00000360366.3, ENST00000371316.3
    Conserved Domains (2) summary
    cd08913
    Location:344583
    START_STARD14-like; Lipid-binding START domain of mammalian STARDT14 and related proteins
    cd03442
    Location:213336
    BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
  2. NM_147161.4NP_671517.1  acyl-coenzyme A thioesterase 11 isoform 2

    See identical proteins and their annotated locations for NP_671517.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses alternate exons in the 3' coding region and UTR, compared to variant 1. The encoded isoform (BFIT2) has a distinct C-terminus compared to isoform BFIT1.
    Source sequence(s)
    AK023937, AL590093
    Consensus CDS
    CCDS593.1
    UniProtKB/Swiss-Prot
    Q8WXI4
    Related
    ENSP00000340260.2, ENST00000343744.6
    Conserved Domains (2) summary
    cd08913
    Location:344583
    START_STARD14-like; Lipid-binding START domain of mammalian STARDT14 and related proteins
    cd03442
    Location:213336
    BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    54548228..54639192
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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