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ACOT11 acyl-CoA thioesterase 11 [ Homo sapiens (human) ]

Gene ID: 26027, updated on 19-Sep-2024

Summary

Official Symbol
ACOT11provided by HGNC
Official Full Name
acyl-CoA thioesterase 11provided by HGNC
Primary source
HGNC:HGNC:18156
See related
Ensembl:ENSG00000162390 MIM:606803; AllianceGenome:HGNC:18156
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
BFIT; THEA; THEM1; STARD14
Summary
This gene encodes a member of the acyl-CoA thioesterase family which catalyse the conversion of activated fatty acids to the corresponding non-esterified fatty acid and coenzyme A. Expression of a mouse homolog in brown adipose tissue is induced by low temperatures and repressed by warm temperatures. Higher levels of expression of the mouse homolog has been found in obesity-resistant mice compared with obesity-prone mice, suggesting a role of acyl-CoA thioesterase 11 in obesity. Alternative splicing results in transcript variants. [provided by RefSeq, Nov 2010]
Expression
Biased expression in kidney (RPKM 35.3), small intestine (RPKM 20.0) and 9 other tissues See more
Orthologs
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Genomic context

See ACOT11 in Genome Data Viewer
Location:
1p32.3
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (54548228..54639192)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (54431560..54519420)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (55013901..55104865)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2784 Neighboring gene MPRA-validated peak241 silencer Neighboring gene transaldolase 1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 920 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 63 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:55035141-55035653 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:55037069-55037592 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:55037593-55038114 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:55044894-55045404 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:55045405-55045913 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:55059979-55060801 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1065 Neighboring gene family with sequence similarity 151 member A Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr1:55102633-55103264 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:55106005-55106518 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:55106519-55107031 Neighboring gene MPRA-validated peak242 silencer Neighboring gene MROH7-TTC4 readthrough (NMD candidate) Neighboring gene maestro heat like repeat family member 7 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:55145240-55146100 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:55163752-55164252 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:55164253-55164753 Neighboring gene MPRA-validated peak243 silencer Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:55181271-55181772 Neighboring gene tetratricopeptide repeat domain 4

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Potential readthrough

Included gene: MROH7

Clone Names

  • KIAA0707, DKFZp667O1916

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
 
enables fatty acyl-CoA hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables fatty acyl-CoA hydrolase activity TAS
Traceable Author Statement
more info
PubMed 
enables lipid binding IEA
Inferred from Electronic Annotation
more info
 
enables long-chain fatty acyl-CoA hydrolase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables long-chain fatty acyl-CoA hydrolase activity IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in acyl-CoA metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in fatty acid metabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in fatty acid metabolic process NAS
Non-traceable Author Statement
more info
PubMed 
involved_in intracellular signal transduction NAS
Non-traceable Author Statement
more info
PubMed 
involved_in negative regulation of cold-induced thermogenesis ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in response to cold ISS
Inferred from Sequence or Structural Similarity
more info
PubMed 
involved_in response to temperature stimulus ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in extracellular exosome HDA PubMed 
located_in mitochondrial matrix IDA
Inferred from Direct Assay
more info
PubMed 
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
acyl-coenzyme A thioesterase 11
Names
START domain containing 14
StAR-related lipid transfer (START) domain containing 14
acyl-CoA thioester hydrolase 11
adipose-associated thioesterase
brown fat-inducible thioesterase
palmitoyl-coenzyme A thioesterase
thioesterase superfamily member 1
thioesterase, adipose associated
NP_056362.1
NP_671517.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015547.4NP_056362.1  acyl-coenzyme A thioesterase 11 isoform 1

    See identical proteins and their annotated locations for NP_056362.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (BFIT1) of this protein.
    Source sequence(s)
    AF416921, AL590093, DA121227
    Consensus CDS
    CCDS592.1
    UniProtKB/Swiss-Prot
    B1AQ22, D3DQ50, O75187, Q52LP1, Q53ER9, Q8WXI4, Q96DI1, Q9H883
    Related
    ENSP00000360366.3, ENST00000371316.3
    Conserved Domains (2) summary
    cd08913
    Location:344583
    START_STARD14-like; Lipid-binding START domain of mammalian STARDT14 and related proteins
    cd03442
    Location:213336
    BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...
  2. NM_147161.4NP_671517.1  acyl-coenzyme A thioesterase 11 isoform 2

    See identical proteins and their annotated locations for NP_671517.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) uses alternate exons in the 3' coding region and UTR, compared to variant 1. The encoded isoform (BFIT2) has a distinct C-terminus compared to isoform BFIT1.
    Source sequence(s)
    AK023937, AL590093
    Consensus CDS
    CCDS593.1
    UniProtKB/Swiss-Prot
    Q8WXI4
    Related
    ENSP00000340260.2, ENST00000343744.7
    Conserved Domains (2) summary
    cd08913
    Location:344583
    START_STARD14-like; Lipid-binding START domain of mammalian STARDT14 and related proteins
    cd03442
    Location:213336
    BFIT_BACH; Brown fat-inducible thioesterase (BFIT). Brain acyl-CoA hydrolase (BACH). These enzymes deacylate long-chain fatty acids by hydrolyzing acyl-CoA thioesters to free fatty acids and CoA-SH. Eukaryotic members of this family are expressed in brain, testis, ...

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    54548228..54639192
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    54431560..54519420
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)