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RPAP1 RNA polymerase II associated protein 1 [ Homo sapiens (human) ]

Gene ID: 26015, updated on 10-Oct-2024

Summary

Official Symbol
RPAP1provided by HGNC
Official Full Name
RNA polymerase II associated protein 1provided by HGNC
Primary source
HGNC:HGNC:24567
See related
Ensembl:ENSG00000103932 MIM:611475; AllianceGenome:HGNC:24567
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This protein forms part of the RNA polymerase II (RNAPII) enzyme complex and may recruit RNAPII to chromatin through its interaction with acetylated histones. [provided by RefSeq, Jul 2012]
Expression
Ubiquitous expression in testis (RPKM 6.0), ovary (RPKM 4.6) and 25 other tissues See more
Orthologs
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Genomic context

See RPAP1 in Genome Data Viewer
Location:
15q15.1
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (41517176..41544257, complement)
RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (39323327..39350423, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (41809374..41836455, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:41785475-41785975 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6359 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6360 Neighboring gene inositol-trisphosphate 3-kinase A Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6361 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:41804857-41805604 Neighboring gene leukocyte receptor tyrosine kinase Neighboring gene MPRA-validated peak2307 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:41835695-41836276 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:41844728-41844829 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:41850829-41851330 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6365 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:41851897-41852538 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:41854571-41855258 Neighboring gene elongin C pseudogene 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:41856635-41857321 Neighboring gene TYRO3 protein tyrosine kinase Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:41860135-41860642 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:41860643-41861148 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:41861657-41862163

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • MGC858, FLJ12732, KIAA1403, DKFZp727M111

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables nucleotidyltransferase activity IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of DNA-directed RNA polymerase complex IEA
Inferred from Electronic Annotation
more info
 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
RNA polymerase II-associated protein 1

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015540.4NP_056355.2  RNA polymerase II-associated protein 1

    See identical proteins and their annotated locations for NP_056355.2

    Status: REVIEWED

    Source sequence(s)
    AC016134
    Consensus CDS
    CCDS10079.1
    UniProtKB/Swiss-Prot
    Q9BWH6, Q9H9I2, Q9NSQ5, Q9P2E4, Q9UFS7
    UniProtKB/TrEMBL
    A8K2F9
    Related
    ENSP00000306123.4, ENST00000304330.9
    Conserved Domains (2) summary
    pfam08620
    Location:356421
    RPAP1_C; RPAP1-like, C-terminal
    pfam08621
    Location:226270
    RPAP1_N; RPAP1-like, N-terminal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    41517176..41544257 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432374.1XP_047288330.1  RNA polymerase II-associated protein 1 isoform X2

  2. XM_047432375.1XP_047288331.1  RNA polymerase II-associated protein 1 isoform X2

  3. XM_005254297.2XP_005254354.1  RNA polymerase II-associated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005254354.1

    UniProtKB/Swiss-Prot
    Q9BWH6, Q9H9I2, Q9NSQ5, Q9P2E4, Q9UFS7
    UniProtKB/TrEMBL
    A8K2F9
    Conserved Domains (2) summary
    pfam08620
    Location:356421
    RPAP1_C; RPAP1-like, C-terminal
    pfam08621
    Location:226270
    RPAP1_N; RPAP1-like, N-terminal

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    39323327..39350423 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054377712.1XP_054233687.1  RNA polymerase II-associated protein 1 isoform X2

  2. XM_054377710.1XP_054233685.1  RNA polymerase II-associated protein 1 isoform X1

  3. XM_054377711.1XP_054233686.1  RNA polymerase II-associated protein 1 isoform X2