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RPAP1 RNA polymerase II associated protein 1 [ Homo sapiens (human) ]

Gene ID: 26015, updated on 6-Jul-2026
Official Symbol
RPAP1provided by HGNC
Official Full Name
RNA polymerase II associated protein 1provided by HGNC
Primary source
HGNC:HGNC:24567
See related
Ensembl:ENSG00000103932 MIM:611475; AllianceGenome:HGNC:24567
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This protein forms part of the RNA polymerase II (RNAPII) enzyme complex and may recruit RNAPII to chromatin through its interaction with acetylated histones. [provided by RefSeq, Jul 2012]
Expression
Ubiquitous expression in testis (RPKM 6.0), ovary (RPKM 4.6) and 25 other tissues See more
Orthologs
all
Try the new Gene page
Try the new Transcripts and proteins table
See RPAP1 in Genome Data Viewer
Location:
15q15.1
Exon count:
25
Annotation release Status Assembly Chr Location
RS_2025_08 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (41517176..41544257, complement)
RS_2025_08 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (39323327..39350423, complement)
RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (41809374..41836455, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:41785475-41785975 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6359 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6360 Neighboring gene inositol-trisphosphate 3-kinase A Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6361 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:41804857-41805604 Neighboring gene leukocyte receptor tyrosine kinase Neighboring gene MPRA-validated peak2307 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:41835695-41836276 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:41844728-41844829 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:41850829-41851330 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6365 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:41851897-41852538 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:41854571-41855258 Neighboring gene elongin C pseudogene 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:41856635-41857321 Neighboring gene TYRO3 protein tyrosine kinase Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:41860135-41860642 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:41860643-41861148 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:41861657-41862163

Go to nucleotide: Graphics FASTA GenBank

  • Project title: Tissue-specific circular RNA induction during human fetal development
  • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
  • BioProject: PRJNA270632
  • Publication: PMID 26076956
  • Analysis date: Mon Apr 2 22:54:59 2018

Related articles in PubMed

  1. RNA polymerase II bypasses 8-oxoguanine in the presence of transcription elongation factor TFIIS. Kuraoka I, et al. DNA Repair (Amst), 2007 Jun 1. PMID 17374514
  2. Gpn2 and Rba50 Directly Participate in the Assembly of the Rpb3 Subcomplex in the Biogenesis of RNA Polymerase II. Zeng F, et al. Mol Cell Biol, 2018 Jul 1. PMID 29661922, Free PMC Article
  3. RPAP1, a novel human RNA polymerase II-associated protein affinity purified with recombinant wild-type and mutated polymerase subunits. Jeronimo C, et al. Mol Cell Biol, 2004 Aug. PMID 15282305, Free PMC Article
  4. Npa3 interacts with Gpn3 and assembly factor Rba50 for RNA polymerase II biogenesis. Liu X, et al. FASEB J, 2020 Nov. PMID 32985767
  5. Mechanistic insights into COVID-19 by global analysis of the SARS-CoV-2 3CL(pro) substrate degradome. Pablos I, et al. Cell Rep, 2021 Oct 26. PMID 34672947, Free PMC Article

See all (62) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Clinical trial of gene-disease association and gene-environment interaction. (HuGE Navigator)
    Title: Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.
  2. SII is important for preventing cellular death due to oxidative DNA damage, assisting RNAPII to bypass 8-oxoG
    Title: RNA polymerase II bypasses 8-oxoguanine in the presence of transcription elongation factor TFIIS.
  3. Data report the purification of RNA polymerase II-associated protein 1 (RPAP1), a 153-kDa polypeptide of unknown function.
    Title: RPAP1, a novel human RNA polymerase II-associated protein affinity purified with recombinant wild-type and mutated polymerase subunits.
Submit: New GeneRIF Correction

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

Products Interactant Other Gene Complex Source Pubs Description

Markers

Homology

Clone Names

  • MGC858, FLJ12732, KIAA1403, DKFZp727M111

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
RNA polymerase II-associated protein 1

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015540.4 → NP_056355.2  RNA polymerase II-associated protein 1

    See identical proteins and their annotated locations for NP_056355.2

    Status: REVIEWED

    Source sequence(s)
    AC016134
    Consensus CDS
    CCDS10079.1
    UniProtKB/Swiss-Prot
    Q9BWH6, Q9H9I2, Q9NSQ5, Q9P2E4, Q9UFS7
    UniProtKB/TrEMBL
    A0ACI8SKQ0
    Related
    ENSP00000306123.4, ENST00000304330.9
    Conserved Domains (2) summary
    pfam08620
    Location:356 → 421
    RPAP1_C; RPAP1-like, C-terminal
    pfam08621
    Location:226 → 270
    RPAP1_N; RPAP1-like, N-terminal

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

    Range
    41517176..41544257 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047432374.1 → XP_047288330.1  RNA polymerase II-associated protein 1 isoform X2

    UniProtKB/TrEMBL
    A0ACI8PMN8, A0ACI8SKQ0
    Related
    ENSP00000537553.1, ENST00000867494.1

  2. XM_047432375.1 → XP_047288331.1  RNA polymerase II-associated protein 1 isoform X2

    UniProtKB/TrEMBL
    A0ACI8PMN8, A0ACI8SKQ0

  3. XM_005254297.2 → XP_005254354.1  RNA polymerase II-associated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005254354.1

    UniProtKB/Swiss-Prot
    Q9BWH6, Q9H9I2, Q9NSQ5, Q9P2E4, Q9UFS7
    UniProtKB/TrEMBL
    A0ACI8SKQ0
    Related
    ENSP00000582315.1, ENST00000912256.1
    Conserved Domains (2) summary
    pfam08620
    Location:356 → 421
    RPAP1_C; RPAP1-like, C-terminal
    pfam08621
    Location:226 → 270
    RPAP1_N; RPAP1-like, N-terminal

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060939.1 Alternate T2T-CHM13v2.0

    Range
    39323327..39350423 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054377712.1 → XP_054233687.1  RNA polymerase II-associated protein 1 isoform X2

    UniProtKB/TrEMBL
    A0ACI8SKQ0

  2. XM_054377710.1 → XP_054233685.1  RNA polymerase II-associated protein 1 isoform X1

    UniProtKB/TrEMBL
    A0ACI8SKQ0

  3. XM_054377711.1 → XP_054233686.1  RNA polymerase II-associated protein 1 isoform X2

    UniProtKB/TrEMBL
    A0ACI8SKQ0
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9BWH6.3 GenPept UniProtKB/Swiss-Prot:Q9BWH6

Gene LinkOut

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