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RPAP1 RNA polymerase II associated protein 1 [ Homo sapiens (human) ]

Gene ID: 26015, updated on 7-Jun-2020

Summary

Official Symbol
RPAP1provided by HGNC
Official Full Name
RNA polymerase II associated protein 1provided by HGNC
Primary source
HGNC:HGNC:24567
See related
Ensembl:ENSG00000103932 MIM:611475
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Summary
This protein forms part of the RNA polymerase II (RNAPII) enzyme complex and may recruit RNAPII to chromatin through its interaction with acetylated histones. [provided by RefSeq, Jul 2012]
Expression
Ubiquitous expression in testis (RPKM 6.0), ovary (RPKM 4.6) and 25 other tissues See more
Orthologs

Genomic context

See RPAP1 in Genome Data Viewer
Location:
15q15.1
Exon count:
25
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 15 NC_000015.10 (41517176..41544257, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (41809374..41836464, complement)

Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene inositol-trisphosphate 3-kinase A Neighboring gene leukocyte receptor tyrosine kinase Neighboring gene elongin C pseudogene 2 Neighboring gene TYRO3 protein tyrosine kinase

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC858, FLJ12732, KIAA1403, DKFZp727M111

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IEA
Inferred from Electronic Annotation
more info
 
DNA-directed 5'-3' RNA polymerase activity IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
nucleus IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
RNA polymerase II-associated protein 1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015540.4NP_056355.2  RNA polymerase II-associated protein 1

    See identical proteins and their annotated locations for NP_056355.2

    Status: REVIEWED

    Source sequence(s)
    AC016134
    Consensus CDS
    CCDS10079.1
    UniProtKB/Swiss-Prot
    Q9BWH6
    UniProtKB/TrEMBL
    A8K2F9
    Related
    ENSP00000306123.4, ENST00000304330.9
    Conserved Domains (2) summary
    pfam08620
    Location:356421
    RPAP1_C; RPAP1-like, C-terminal
    pfam08621
    Location:226270
    RPAP1_N; RPAP1-like, N-terminal

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000015.10 Reference GRCh38.p13 Primary Assembly

    Range
    41517176..41544257 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005254297.1XP_005254354.1  RNA polymerase II-associated protein 1 isoform X1

    See identical proteins and their annotated locations for XP_005254354.1

    UniProtKB/Swiss-Prot
    Q9BWH6
    Conserved Domains (2) summary
    pfam08620
    Location:356421
    RPAP1_C; RPAP1-like, C-terminal
    pfam08621
    Location:226270
    RPAP1_N; RPAP1-like, N-terminal
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