Format

Send to:

Choose Destination

TENM4 teneurin transmembrane protein 4 [ Homo sapiens (human) ]

Gene ID: 26011, updated on 22-Aug-2020

Summary

Official Symbol
TENM4provided by HGNC
Official Full Name
teneurin transmembrane protein 4provided by HGNC
Primary source
HGNC:HGNC:29945
See related
Ensembl:ENSG00000149256 MIM:610084
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
Doc4; ETM5; ODZ4; TEN4; TNM4; ten-4; Ten-M4
Summary
The protein encoded by this gene plays a role in establishing proper neuronal connectivity during development. Defects in this gene have been associated with hereditary essential tremor-5. [provided by RefSeq, Oct 2016]
Expression
Biased expression in ovary (RPKM 7.7), thyroid (RPKM 3.2) and 8 other tissues See more
Orthologs

Genomic context

See TENM4 in Genome Data Viewer
Location:
11q14.1
Exon count:
36
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (78652829..79441030, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (78364328..79152014, complement)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene RNA, U6 small nuclear 311, pseudogene Neighboring gene COP9 signalosome subunit 8 pseudogene 3 Neighboring gene microRNA 708 Neighboring gene microRNA 5579 Neighboring gene uncharacterized LOC105369405 Neighboring gene uncharacterized LOC107984424

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Collaborative genome-wide association analysis supports a role for ANK3 and CACNA1C in bipolar disorder.
GeneReviews: Not available
Genetic correlates of brain aging on MRI and cognitive test measures: a genome-wide association and linkage analysis in the Framingham Study.
GeneReviews: Not available
Genome-wide association study of retinopathy in individuals without diabetes.
GeneReviews: Not available
Genome-wide association study reveals two new risk loci for bipolar disorder.
GeneReviews: Not available
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis.
GeneReviews: Not available
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4.
GeneReviews: Not available
Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
GeneReviews: Not available
Tremor, hereditary essential, 5
MedGen: C4225223 OMIM: 616736 GeneReviews: Not available
Compare labs

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ99165

Gene Ontology Provided by GOA

Function Evidence Code Pubs
cell adhesion molecule binding IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein heterodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein homodimerization activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
protein homodimerization activity ISS
Inferred from Sequence or Structural Similarity
more info
 
Process Evidence Code Pubs
cardiac cell fate specification IEA
Inferred from Electronic Annotation
more info
 
cardiac muscle cell proliferation IEA
Inferred from Electronic Annotation
more info
 
central nervous system myelin formation IMP
Inferred from Mutant Phenotype
more info
PubMed 
central nervous system myelin formation ISS
Inferred from Sequence or Structural Similarity
more info
 
gastrulation with mouth forming second IEA
Inferred from Electronic Annotation
more info
 
heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron development IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron development IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gastrulation ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of myelination ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of oligodendrocyte differentiation ISS
Inferred from Sequence or Structural Similarity
more info
 
regulation of myelination IMP
Inferred from Mutant Phenotype
more info
PubMed 
signal transduction IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
cytoplasm ISS
Inferred from Sequence or Structural Similarity
more info
 
integral component of plasma membrane IEA
Inferred from Electronic Annotation
more info
 
neuron projection IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
neuron projection ISS
Inferred from Sequence or Structural Similarity
more info
 
nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
teneurin-4
Names
odz, odd Oz/ten-m homolog 4
protein Odd Oz/ten-m homolog 4
tenascin-M4

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_051803.1 RefSeqGene

    Range
    4622..792823
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001098816.3NP_001092286.2  teneurin-4

    See identical proteins and their annotated locations for NP_001092286.2

    Status: REVIEWED

    Source sequence(s)
    AB037723, AP001838, AP002515, AP002768, AP002957, BX640737, DR000247
    Consensus CDS
    CCDS44688.1
    UniProtKB/Swiss-Prot
    Q6N022
    Related
    ENSP00000278550.7, ENST00000278550.12
    Conserved Domains (10) summary
    COG3209
    Location:16822474
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:12321271
    NHL; NHL repeat [structural motif]
    TIGR01643
    Location:16761716
    YD_repeat_2x; YD repeat (two copies)
    TIGR03696
    Location:23822461
    Rhs_assc_core; RHS repeat-associated core domain
    pfam01500
    Location:627775
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam06484
    Location:11340
    Ten_N; Teneurin Intracellular Region
    pfam07974
    Location:631657
    EGF_2; EGF-like domain
    pfam15636
    Location:26872762
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:12221563
    NHL; NHL repeat unit of beta-propeller proteins
    cl19567
    Location:745786
    DSL; Delta serrate ligand

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    78652829..79441030 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017017525.1XP_016873014.1  teneurin-4 isoform X1

  2. XM_017017526.1XP_016873015.1  teneurin-4 isoform X2

    UniProtKB/Swiss-Prot
    Q6N022
    Conserved Domains (10) summary
    COG3209
    Location:16822474
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:12321271
    NHL; NHL repeat [structural motif]
    TIGR01643
    Location:16761716
    YD_repeat_2x; YD repeat (two copies)
    TIGR03696
    Location:23822461
    Rhs_assc_core; RHS repeat-associated core domain
    pfam01500
    Location:627775
    Keratin_B2; Keratin, high sulfur B2 protein
    pfam06484
    Location:11340
    Ten_N; Teneurin Intracellular Region
    pfam07974
    Location:631657
    EGF_2; EGF-like domain
    pfam15636
    Location:26872762
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:12221563
    NHL; NHL repeat unit of beta-propeller proteins
    cl19567
    Location:745786
    DSL; Delta serrate ligand
  3. XM_011544933.3XP_011543235.1  teneurin-4 isoform X3

    Conserved Domains (6) summary
    COG3209
    Location:7501446
    RhsA; Uncharacterized conserved protein RhaS, contains 28 RHS repeats [General function prediction only]
    cd05819
    Location:380419
    NHL; NHL repeat [structural motif]
    TIGR01643
    Location:824864
    YD_repeat_2x; YD repeat (two copies)
    TIGR03696
    Location:15301609
    Rhs_assc_core; RHS repeat-associated core domain
    pfam15636
    Location:18351910
    Tox-GHH; GHH signature containing HNH/Endo VII superfamily nuclease toxin
    cl18310
    Location:370711
    NHL; NHL repeat unit of beta-propeller proteins
Support Center