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ZZZ3 zinc finger ZZ-type containing 3 [ Homo sapiens (human) ]

Gene ID: 26009, updated on 22-Aug-2021

Summary

Official Symbol
ZZZ3provided by HGNC
Official Full Name
zinc finger ZZ-type containing 3provided by HGNC
Primary source
HGNC:HGNC:24523
See related
Ensembl:ENSG00000036549
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATAC1
Expression
Ubiquitous expression in thyroid (RPKM 9.6), ovary (RPKM 6.7) and 25 other tissues See more
Orthologs
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Genomic context

See ZZZ3 in Genome Data Viewer
Location:
1p31.1
Exon count:
17
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (77561526..77683440, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (78028101..78149083, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 3902 Neighboring gene adenylate kinase 5 Neighboring gene RNA, U7 small nuclear 8 pseudogene Neighboring gene RNA, 5S ribosomal pseudogene 20 Neighboring gene RNA, 7SL, cytoplasmic 370, pseudogene Neighboring gene ubiquitin specific peptidase 33 Neighboring gene actin gamma 1 pseudogene 21

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

Associated conditions

Description Tests
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
GeneReviews: Not available

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10362, DKFZp564I052, DKFZp313N0119

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in histone H4 acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
ZZ-type zinc finger-containing protein 3
Names
ATAC component 1 homolog
zinc finger, ZZ domain containing 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308237.2NP_001295166.1  ZZ-type zinc finger-containing protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001295166.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon, lacks an alternate exon in the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC093575, BC035079, BC035818, BX640658, CA448091
    Consensus CDS
    CCDS76172.1
    UniProtKB/Swiss-Prot
    Q8IYH5
    Related
    ENSP00000359834.1, ENST00000370798.5
    Conserved Domains (2) summary
    cd00167
    Location:161209
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    cd02341
    Location:327378
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
  2. NM_001376146.1NP_001363075.1  ZZ-type zinc finger-containing protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC093575, AC114487, AC118549
    Conserved Domains (2) summary
    cd02341
    Location:821872
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    pfam00249
    Location:655703
    Myb_DNA-binding; Myb-like DNA-binding domain
  3. NM_001376147.1NP_001363076.1  ZZ-type zinc finger-containing protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC093575, AC114487, AC118549
    Conserved Domains (2) summary
    cd02341
    Location:821872
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    pfam00249
    Location:655703
    Myb_DNA-binding; Myb-like DNA-binding domain
  4. NM_001376148.1NP_001363077.1  ZZ-type zinc finger-containing protein 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC093575, AC114487, AC118549
    Conserved Domains (2) summary
    cd02341
    Location:820871
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    pfam00249
    Location:654702
    Myb_DNA-binding; Myb-like DNA-binding domain
  5. NM_001376149.1NP_001363078.1  ZZ-type zinc finger-containing protein 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC093575, AC114487, AC118549
    Conserved Domains (2) summary
    cd02341
    Location:820871
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    pfam00249
    Location:654702
    Myb_DNA-binding; Myb-like DNA-binding domain
  6. NM_001376151.1NP_001363080.1  ZZ-type zinc finger-containing protein 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC093575, AC114487, AC118549
    Conserved Domains (2) summary
    cd02341
    Location:820871
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    pfam00249
    Location:654702
    Myb_DNA-binding; Myb-like DNA-binding domain
  7. NM_001376153.1NP_001363082.1  ZZ-type zinc finger-containing protein 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC093575, AC114487, AC118549
    Conserved Domains (2) summary
    cd02341
    Location:820871
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    pfam00249
    Location:654702
    Myb_DNA-binding; Myb-like DNA-binding domain
  8. NM_001376154.1NP_001363083.1  ZZ-type zinc finger-containing protein 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC093575, AC114487, AC118549
    Conserved Domains (2) summary
    cd02341
    Location:820871
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    pfam00249
    Location:654702
    Myb_DNA-binding; Myb-like DNA-binding domain
  9. NM_001376155.1NP_001363084.1  ZZ-type zinc finger-containing protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC093575, AC114487, AC118549
    Conserved Domains (2) summary
    cd00167
    Location:161209
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    cd02341
    Location:327378
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
  10. NM_001376156.1NP_001363085.1  ZZ-type zinc finger-containing protein 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC093575, AC114487, AC118549
    Related
    ENST00000481346.5
    Conserved Domains (2) summary
    cd00167
    Location:160208
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    cd02341
    Location:326377
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
  11. NM_015534.6NP_056349.1  ZZ-type zinc finger-containing protein 3 isoform 1

    See identical proteins and their annotated locations for NP_056349.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC093575, BX640658, BX641001, CA448091
    Consensus CDS
    CCDS677.1
    UniProtKB/Swiss-Prot
    Q8IYH5
    Related
    ENSP00000359837.3, ENST00000370801.8
    Conserved Domains (2) summary
    cd02341
    Location:821872
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    pfam00249
    Location:655703
    Myb_DNA-binding; Myb-like DNA-binding domain

RNA

  1. NR_164775.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC093575, AC114487, AC118549
  2. NR_164776.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC093575, AC114487, AC118549
  3. NR_164777.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC093575, AC114487, AC118549

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    77561526..77683440 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005270729.4XP_005270786.1  ZZ-type zinc finger-containing protein 3 isoform X3

    See identical proteins and their annotated locations for XP_005270786.1

    UniProtKB/Swiss-Prot
    Q8IYH5
    Conserved Domains (2) summary
    cd00167
    Location:161209
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    cd02341
    Location:327378
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.

RNA

  1. XR_001737104.1 RNA Sequence

  2. XR_001737103.1 RNA Sequence

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