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ZZZ3 zinc finger ZZ-type containing 3 [ Homo sapiens (human) ]

Gene ID: 26009, updated on 21-Dec-2022

Summary

Official Symbol
ZZZ3provided by HGNC
Official Full Name
zinc finger ZZ-type containing 3provided by HGNC
Primary source
HGNC:HGNC:24523
See related
Ensembl:ENSG00000036549 MIM:619892; AllianceGenome:HGNC:24523
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
ATAC1
Summary
Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in histone H4 acetylation. Located in nucleolus and nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 9.6), ovary (RPKM 6.7) and 25 other tissues See more
Orthologs
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Try the new Transcript table

Genomic context

See ZZZ3 in Genome Data Viewer
Location:
1p31.1
Exon count:
19
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (77562416..77683398, complement)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (77401275..77522228, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (78028101..78149083, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene adenylate kinase 5 Neighboring gene uncharacterized LOC124904202 Neighboring gene Sharpr-MPRA regulatory region 12904 Neighboring gene RNA, 5S ribosomal pseudogene 20 Neighboring gene RNA, 7SL, cytoplasmic 370, pseudogene Neighboring gene ubiquitin specific peptidase 33 Neighboring gene actin gamma 1 pseudogene 21

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Phenotypes

EBI GWAS Catalog

Description
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
EBI GWAS Catalog

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ10362, DKFZp564I052, DKFZp313N0119

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
 
enables lysine-acetylated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables methylated histone binding IDA
Inferred from Direct Assay
more info
PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in histone H3 acetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in histone H3-K14 acetylation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in histone H3-K14 acetylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in histone H4 acetylation IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in regulation of DNA-templated transcription IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of cell cycle ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of cell division IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of cell division ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of embryonic development ISO
Inferred from Sequence Orthology
more info
 
involved_in regulation of embryonic development ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of histone deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of histone deacetylation ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of transcription by RNA polymerase II ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in regulation of tubulin deacetylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in regulation of tubulin deacetylation ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
part_of ATAC complex IDA
Inferred from Direct Assay
more info
PubMed 
part_of ATAC complex ISO
Inferred from Sequence Orthology
more info
 
located_in mitotic spindle NAS
Non-traceable Author Statement
more info
PubMed 
located_in nucleolus IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 

General protein information

Preferred Names
ZZ-type zinc finger-containing protein 3
Names
ATAC component 1 homolog
zinc finger, ZZ domain containing 3

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001308237.2NP_001295166.1  ZZ-type zinc finger-containing protein 3 isoform 2

    See identical proteins and their annotated locations for NP_001295166.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) contains an alternate 5' terminal exon, lacks an alternate exon in the 5' coding region, and initiates translation at an alternate start codon, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter than isoform 1.
    Source sequence(s)
    AC093575, BC035079, BC035818, BX640658, CA448091
    Consensus CDS
    CCDS76172.1
    UniProtKB/Swiss-Prot
    Q8IYH5
    Related
    ENSP00000359834.1, ENST00000370798.5
    Conserved Domains (2) summary
    cd00167
    Location:161209
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    cd02341
    Location:327378
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
  2. NM_001376146.1NP_001363075.1  ZZ-type zinc finger-containing protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC093575, AC114487, AC118549
    Consensus CDS
    CCDS677.1
    UniProtKB/Swiss-Prot
    Q9Y4U0
    Conserved Domains (2) summary
    cd02341
    Location:821872
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    pfam00249
    Location:655703
    Myb_DNA-binding; Myb-like DNA-binding domain
  3. NM_001376147.1NP_001363076.1  ZZ-type zinc finger-containing protein 3 isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC093575, AC114487, AC118549
    Consensus CDS
    CCDS677.1
    UniProtKB/Swiss-Prot
    Q9Y4U0
    Conserved Domains (2) summary
    cd02341
    Location:821872
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    pfam00249
    Location:655703
    Myb_DNA-binding; Myb-like DNA-binding domain
  4. NM_001376148.1NP_001363077.1  ZZ-type zinc finger-containing protein 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC093575, AC114487, AC118549
    Conserved Domains (2) summary
    cd02341
    Location:820871
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    pfam00249
    Location:654702
    Myb_DNA-binding; Myb-like DNA-binding domain
  5. NM_001376149.1NP_001363078.1  ZZ-type zinc finger-containing protein 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC093575, AC114487, AC118549
    Conserved Domains (2) summary
    cd02341
    Location:820871
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    pfam00249
    Location:654702
    Myb_DNA-binding; Myb-like DNA-binding domain
  6. NM_001376151.1NP_001363080.1  ZZ-type zinc finger-containing protein 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC093575, AC114487, AC118549
    Conserved Domains (2) summary
    cd02341
    Location:820871
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    pfam00249
    Location:654702
    Myb_DNA-binding; Myb-like DNA-binding domain
  7. NM_001376153.1NP_001363082.1  ZZ-type zinc finger-containing protein 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC093575, AC114487, AC118549
    Conserved Domains (2) summary
    cd02341
    Location:820871
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    pfam00249
    Location:654702
    Myb_DNA-binding; Myb-like DNA-binding domain
  8. NM_001376154.1NP_001363083.1  ZZ-type zinc finger-containing protein 3 isoform 3

    Status: VALIDATED

    Source sequence(s)
    AC093575, AC114487, AC118549
    Conserved Domains (2) summary
    cd02341
    Location:820871
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    pfam00249
    Location:654702
    Myb_DNA-binding; Myb-like DNA-binding domain
  9. NM_001376155.1NP_001363084.1  ZZ-type zinc finger-containing protein 3 isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC093575, AC114487, AC118549
    Consensus CDS
    CCDS76172.1
    Conserved Domains (2) summary
    cd00167
    Location:161209
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    cd02341
    Location:327378
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
  10. NM_001376156.1NP_001363085.1  ZZ-type zinc finger-containing protein 3 isoform 4

    Status: VALIDATED

    Source sequence(s)
    AC093575, AC114487, AC118549
    Conserved Domains (2) summary
    cd00167
    Location:160208
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    cd02341
    Location:326377
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
  11. NM_015534.6NP_056349.1  ZZ-type zinc finger-containing protein 3 isoform 1

    See identical proteins and their annotated locations for NP_056349.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC093575, BX640658, BX641001, CA448091
    Consensus CDS
    CCDS677.1
    UniProtKB/Swiss-Prot
    Q8IYH5, Q9Y4U0
    Related
    ENSP00000359837.3, ENST00000370801.8
    Conserved Domains (2) summary
    cd02341
    Location:821872
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
    pfam00249
    Location:655703
    Myb_DNA-binding; Myb-like DNA-binding domain

RNA

  1. NR_164775.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC093575, AC114487, AC118549
  2. NR_164776.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC093575, AC114487, AC118549
  3. NR_164777.1 RNA Sequence

    Status: VALIDATED

    Source sequence(s)
    AC093575, AC114487, AC118549

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

    Range
    77562416..77683398 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_047417341.1XP_047273297.1  ZZ-type zinc finger-containing protein 3 isoform X3

  2. XM_005270729.5XP_005270786.1  ZZ-type zinc finger-containing protein 3 isoform X2

    See identical proteins and their annotated locations for XP_005270786.1

    UniProtKB/Swiss-Prot
    Q8IYH5
    Conserved Domains (2) summary
    cd00167
    Location:161209
    SANT; 'SWI3, ADA2, N-CoR and TFIIIB' DNA-binding domains. Tandem copies of the domain bind telomeric DNA tandem repeatsas part of the capping complex. Binding is sequence dependent for repeats which contain the G/C rich motif [C2-3 A (CA)1-6]. The domain is ...
    cd02341
    Location:327378
    ZZ_ZZZ3; Zinc finger, ZZ type. Zinc finger present in ZZZ3 (ZZ finger containing 3) and related proteins. The ZZ motif coordinates two zinc ions and most likely participates in ligand binding or molecular scaffolding.
  3. XM_047417342.1XP_047273298.1  ZZ-type zinc finger-containing protein 3 isoform X3

    Related
    ENST00000481346.5
  4. XM_047417333.1XP_047273289.1  ZZ-type zinc finger-containing protein 3 isoform X2

  5. XM_047417337.1XP_047273293.1  ZZ-type zinc finger-containing protein 3 isoform X3

  6. XM_047417326.1XP_047273282.1  ZZ-type zinc finger-containing protein 3 isoform X2

  7. XM_047417329.1XP_047273285.1  ZZ-type zinc finger-containing protein 3 isoform X2

  8. XM_047417325.1XP_047273281.1  ZZ-type zinc finger-containing protein 3 isoform X1

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060925.1 Alternate T2T-CHM13v2.0

    Range
    77401275..77522228 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)