U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

GORASP2 golgi reassembly stacking protein 2 [ Homo sapiens (human) ]

Gene ID: 26003, updated on 6-Sep-2022

Summary

Official Symbol
GORASP2provided by HGNC
Official Full Name
golgi reassembly stacking protein 2provided by HGNC
Primary source
HGNC:HGNC:17500
See related
Ensembl:ENSG00000115806 MIM:608693; AllianceGenome:HGNC:17500
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p59; GRS2; GOLPH6; GRASP55
Summary
This gene encodes a member of the Golgi reassembly stacking protein family. These proteins may play a role in the stacking of Golgi cisternae and Golgi ribbon formation, as well as Golgi fragmentation during apoptosis or mitosis. The encoded protein also plays a role in the intracellular transport of transforming growth factor alpha and may function as a molecular chaperone. A pseudogene of this gene is located on the short arm of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Expression
Ubiquitous expression in thyroid (RPKM 25.6), placenta (RPKM 23.9) and 25 other tissues See more
Orthologs
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

See GORASP2 in Genome Data Viewer
Location:
2q31.1
Exon count:
11
Annotation release Status Assembly Chr Location
110 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (170928477..170967130)
110 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (171405614..171444257)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (171784987..171823640)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene glutamate decarboxylase 1 Neighboring gene Sharpr-MPRA regulatory region 14 Neighboring gene uncharacterized LOC124906091 Neighboring gene tousled like kinase 1 Neighboring gene uncharacterized LOC124906092

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of golgi reassembly stacking protein 2 (GORASP2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13139, DKFZp434D156

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in Golgi membrane TAS
Traceable Author Statement
more info
 
located_in cis-Golgi network IC
Inferred by Curator
more info
PubMed 
located_in endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
located_in membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
Golgi reassembly-stacking protein 2
Names
golgi phosphoprotein 6
golgi reassembly stacking protein 2, 55kDa

NCBI Reference Sequences (RefSeq)

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001201428.2NP_001188357.1  Golgi reassembly-stacking protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001188357.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC010092, AL117430, BQ004408
    UniProtKB/Swiss-Prot
    Q9H8Y8
    Conserved Domains (1) summary
    pfam04495
    Location:1137
    GRASP55_65; GRASP55/65 PDZ-like domain
  2. NM_015530.5NP_056345.3  Golgi reassembly-stacking protein 2 isoform 1

    See identical proteins and their annotated locations for NP_056345.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC010092, BC007770, BQ004408
    Consensus CDS
    CCDS33325.1
    UniProtKB/Swiss-Prot
    Q9H8Y8, Q9UFW4
    Related
    ENSP00000234160.4, ENST00000234160.5
    Conserved Domains (3) summary
    pfam04495
    Location:69205
    GRASP55_65; GRASP55/65 PDZ-like domain
    cl00117
    Location:14100
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cl26464
    Location:241397
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 110 details...Open this link in a new tab

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    170928477..170967130
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    171405614..171444257
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)