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GORASP2 golgi reassembly stacking protein 2 [ Homo sapiens (human) ]

Gene ID: 26003, updated on 23-Aug-2020

Summary

Official Symbol
GORASP2provided by HGNC
Official Full Name
golgi reassembly stacking protein 2provided by HGNC
Primary source
HGNC:HGNC:17500
See related
Ensembl:ENSG00000115806 MIM:608693
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
p59; GRS2; GOLPH6; GRASP55
Summary
This gene encodes a member of the Golgi reassembly stacking protein family. These proteins may play a role in the stacking of Golgi cisternae and Golgi ribbon formation, as well as Golgi fragmentation during apoptosis or mitosis. The encoded protein also plays a role in the intracellular transport of transforming growth factor alpha and may function as a molecular chaperone. A pseudogene of this gene is located on the short arm of chromosome 2. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jan 2011]
Expression
Ubiquitous expression in thyroid (RPKM 25.6), placenta (RPKM 23.9) and 25 other tissues See more
Orthologs

Genomic context

See GORASP2 in Genome Data Viewer
Location:
2q31.1
Exon count:
11
Annotation release Status Assembly Chr Location
109.20200815 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (170928477..170967130)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (171784948..171823645)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101926913 Neighboring gene glutamate rich 2 Neighboring gene glutamate decarboxylase 1 Neighboring gene tousled like kinase 1 Neighboring gene uncharacterized protein C9orf85-like Neighboring gene uncharacterized LOC107983995

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
A genome-wide study of common SNPs and CNVs in cognitive performance in the CANTAB.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of golgi reassembly stacking protein 2 (GORASP2) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ13139, DKFZp434D156

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cell differentiation IEA
Inferred from Electronic Annotation
more info
 
establishment of protein localization to plasma membrane IDA
Inferred from Direct Assay
more info
PubMed 
establishment of protein localization to plasma membrane IMP
Inferred from Mutant Phenotype
more info
PubMed 
organelle assembly IMP
Inferred from Mutant Phenotype
more info
PubMed 
organelle organization IMP
Inferred from Mutant Phenotype
more info
PubMed 
response to endoplasmic reticulum stress IDA
Inferred from Direct Assay
more info
PubMed 
spermatogenesis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Golgi apparatus IDA
Inferred from Direct Assay
more info
PubMed 
Golgi membrane IDA
Inferred from Direct Assay
more info
PubMed 
Golgi membrane TAS
Traceable Author Statement
more info
 
endoplasmic reticulum membrane IDA
Inferred from Direct Assay
more info
PubMed 
membrane TAS
Traceable Author Statement
more info
PubMed 

General protein information

Preferred Names
Golgi reassembly-stacking protein 2
Names
golgi phosphoprotein 6
golgi reassembly stacking protein 2, 55kDa

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001201428.2NP_001188357.1  Golgi reassembly-stacking protein 2 isoform 2

    See identical proteins and their annotated locations for NP_001188357.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region and initiates translation at a downstream start codon, compared to variant 1. The resulting isoform (2) has a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AC010092, AL117430, BQ004408
    UniProtKB/Swiss-Prot
    Q9H8Y8
    Conserved Domains (1) summary
    pfam04495
    Location:1137
    GRASP55_65; GRASP55/65 PDZ-like domain
  2. NM_015530.5NP_056345.3  Golgi reassembly-stacking protein 2 isoform 1

    See identical proteins and their annotated locations for NP_056345.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC010092, BC007770, BQ004408
    Consensus CDS
    CCDS33325.1
    UniProtKB/Swiss-Prot
    Q9H8Y8
    Related
    ENSP00000234160.4, ENST00000234160.5
    Conserved Domains (3) summary
    pfam04495
    Location:69205
    GRASP55_65; GRASP55/65 PDZ-like domain
    cl00117
    Location:14100
    PDZ; PDZ domain, also called DHR (Dlg homologous region) or GLGF (after a conserved sequence motif). Many PDZ domains bind C-terminal polypeptides, though binding to internal (non-C-terminal) polypeptides and even to lipids has been demonstrated. ...
    cl26464
    Location:241397
    Atrophin-1; Atrophin-1 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20200815

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    170928477..170967130
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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