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RNF167 ring finger protein 167 [ Homo sapiens (human) ]

Gene ID: 26001, updated on 1-Jun-2020

Summary

Official Symbol
RNF167provided by HGNC
Official Full Name
ring finger protein 167provided by HGNC
Primary source
HGNC:HGNC:24544
See related
Ensembl:ENSG00000108523 MIM:610431
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
LP2254; RING105; 5730408C10Rik
Summary
RNF167 is an E3 ubiquitin ligase that interacts with TSSC5 (SLC22A18; MIM 602631) and, together with UBCH6 (UBE2E1; MIM 602916), facilitates TSSC5 polyubiquitylation (Yamada and Gorbsky, 2006 [PubMed 16314844]).[supplied by OMIM, Mar 2008]
Expression
Ubiquitous expression in testis (RPKM 26.0), thyroid (RPKM 24.0) and 25 other tissues See more
Orthologs

Genomic context

See RNF167 in Genome Data Viewer
Location:
17p13.2
Exon count:
12
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (4940092..4945222)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (4843328..4848517)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene chromosome 17 open reading frame 107 Neighboring gene cholinergic receptor nicotinic epsilon subunit Neighboring gene glycoprotein Ib platelet subunit alpha Neighboring gene solute carrier family 25 member 11 Neighboring gene profilin 1 Neighboring gene enolase 3

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp566H073

Gene Ontology Provided by GOA

Function Evidence Code Pubs
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
ubiquitin protein ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
ubiquitin-protein transferase activity IDA
Inferred from Direct Assay
more info
PubMed 
zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
negative regulation of cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
negative regulation of cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
protein polyubiquitination IDA
Inferred from Direct Assay
more info
PubMed 
ubiquitin-dependent protein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Component Evidence Code Pubs
cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
endomembrane system IEA
Inferred from Electronic Annotation
more info
 
integral component of membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
E3 ubiquitin-protein ligase RNF167
Names
RING-type E3 ubiquitin transferase RNF167
NP_001307285.1
NP_001307286.1
NP_001307287.1
NP_001307288.1
NP_001307289.1
NP_001307290.1
NP_001307291.1
NP_001307292.1
NP_001307293.1
NP_001307294.1
NP_001357232.1
NP_001357233.1
NP_001357234.1
NP_001357235.1
NP_001357236.1
NP_001357237.1
NP_001357240.1
NP_001357242.1
NP_001362414.1
NP_056343.1
XP_016879917.1

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001320356.2NP_001307285.1  E3 ubiquitin-protein ligase RNF167 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC004771
    Consensus CDS
    CCDS11060.1
    UniProtKB/Swiss-Prot
    Q9H6Y7
    Related
    ENSP00000459324.1, ENST00000571816.5
    Conserved Domains (2) summary
    cd02123
    Location:20170
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    cd16797
    Location:228273
    RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins
  2. NM_001320357.2NP_001307286.1  E3 ubiquitin-protein ligase RNF167 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC004771
    Consensus CDS
    CCDS11060.1
    UniProtKB/Swiss-Prot
    Q9H6Y7
    Conserved Domains (2) summary
    cd02123
    Location:20170
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    cd16797
    Location:228273
    RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins
  3. NM_001320358.2NP_001307287.1  E3 ubiquitin-protein ligase RNF167 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC004771
    Consensus CDS
    CCDS11060.1
    UniProtKB/Swiss-Prot
    Q9H6Y7
    Conserved Domains (2) summary
    cd02123
    Location:20170
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    cd16797
    Location:228273
    RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins
  4. NM_001320359.2NP_001307288.1  E3 ubiquitin-protein ligase RNF167 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC004771
    Consensus CDS
    CCDS11060.1
    UniProtKB/Swiss-Prot
    Q9H6Y7
    Related
    ENSP00000458794.1, ENST00000572430.5
    Conserved Domains (2) summary
    cd02123
    Location:20170
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    cd16797
    Location:228273
    RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins
  5. NM_001320360.2NP_001307289.1  E3 ubiquitin-protein ligase RNF167 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC004771
    Consensus CDS
    CCDS11060.1
    UniProtKB/Swiss-Prot
    Q9H6Y7
    Conserved Domains (2) summary
    cd02123
    Location:20170
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    cd16797
    Location:228273
    RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins
  6. NM_001320361.2NP_001307290.1  E3 ubiquitin-protein ligase RNF167 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC004771
    Consensus CDS
    CCDS11060.1
    UniProtKB/Swiss-Prot
    Q9H6Y7
    Conserved Domains (2) summary
    cd02123
    Location:20170
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    cd16797
    Location:228273
    RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins
  7. NM_001320362.2NP_001307291.1  E3 ubiquitin-protein ligase RNF167 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC004771
    Consensus CDS
    CCDS82040.1
    UniProtKB/Swiss-Prot
    Q9H6Y7
    UniProtKB/TrEMBL
    I3L0L6
    Conserved Domains (2) summary
    cd02123
    Location:1135
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    cd16797
    Location:193238
    RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins
  8. NM_001320363.2NP_001307292.1  E3 ubiquitin-protein ligase RNF167 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC004771
    Consensus CDS
    CCDS82040.1
    UniProtKB/Swiss-Prot
    Q9H6Y7
    UniProtKB/TrEMBL
    I3L0L6
    Conserved Domains (2) summary
    cd02123
    Location:1135
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    cd16797
    Location:193238
    RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins
  9. NM_001320364.2NP_001307293.1  E3 ubiquitin-protein ligase RNF167 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC004771
    Consensus CDS
    CCDS82040.1
    UniProtKB/Swiss-Prot
    Q9H6Y7
    UniProtKB/TrEMBL
    I3L0L6
    Conserved Domains (2) summary
    cd02123
    Location:1135
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    cd16797
    Location:193238
    RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins
  10. NM_001320365.2NP_001307294.1  E3 ubiquitin-protein ligase RNF167 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC004771
    Consensus CDS
    CCDS82040.1
    UniProtKB/Swiss-Prot
    Q9H6Y7
    UniProtKB/TrEMBL
    I3L0L6
    Related
    ENSP00000458189.1, ENST00000576229.5
    Conserved Domains (2) summary
    cd02123
    Location:1135
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    cd16797
    Location:193238
    RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins
  11. NM_001370303.1NP_001357232.1  E3 ubiquitin-protein ligase RNF167 isoform c precursor

    Status: VALIDATED

    Source sequence(s)
    AC004771
    Conserved Domains (2) summary
    cd02123
    Location:20170
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    cd16797
    Location:252297
    RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins
  12. NM_001370304.1NP_001357233.1  E3 ubiquitin-protein ligase RNF167 isoform c precursor

    Status: VALIDATED

    Source sequence(s)
    AC004771
    Conserved Domains (2) summary
    cd02123
    Location:20170
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    cd16797
    Location:252297
    RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins
  13. NM_001370305.1NP_001357234.1  E3 ubiquitin-protein ligase RNF167 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC004771
    Conserved Domains (2) summary
    cd02123
    Location:20170
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    cd16797
    Location:228273
    RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins
  14. NM_001370306.1NP_001357235.1  E3 ubiquitin-protein ligase RNF167 isoform d precursor

    Status: VALIDATED

    Source sequence(s)
    AC004771
    Conserved Domains (2) summary
    cd02123
    Location:20170
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    cd16797
    Location:227272
    RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins
  15. NM_001370307.1NP_001357236.1  E3 ubiquitin-protein ligase RNF167 isoform d precursor

    Status: VALIDATED

    Source sequence(s)
    AC004771
    Conserved Domains (2) summary
    cd02123
    Location:20170
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    cd16797
    Location:227272
    RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins
  16. NM_001370308.1NP_001357237.1  E3 ubiquitin-protein ligase RNF167 isoform e

    Status: VALIDATED

    Source sequence(s)
    AC004771
    Conserved Domains (2) summary
    cd02123
    Location:1135
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    cd16797
    Location:217262
    RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins
  17. NM_001370311.1NP_001357240.1  E3 ubiquitin-protein ligase RNF167 isoform b

    Status: VALIDATED

    Source sequence(s)
    AC004771
    Conserved Domains (2) summary
    cd02123
    Location:1135
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    cd16797
    Location:193238
    RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins
  18. NM_001370313.1NP_001357242.1  E3 ubiquitin-protein ligase RNF167 isoform f precursor

    Status: VALIDATED

    Source sequence(s)
    AC004771
    Conserved Domains (2) summary
    cd16797
    Location:186231
    RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins
    cl28883
    Location:20128
    PA; Protease-associated (PA) domain. The PA domain is an insert domain in a diverse fraction of proteases. The significance of the PA domain to many of the proteins in which it is inserted is undetermined. It may be a protein-protein interaction domain. At ...
  19. NM_001375485.1NP_001362414.1  E3 ubiquitin-protein ligase RNF167 isoform a precursor

    Status: VALIDATED

    Source sequence(s)
    AC004771
    Related
    ENSP00000460190.1, ENST00000575111.5
  20. NM_015528.3NP_056343.1  E3 ubiquitin-protein ligase RNF167 isoform a precursor

    See identical proteins and their annotated locations for NP_056343.1

    Status: VALIDATED

    Source sequence(s)
    AC004771
    Consensus CDS
    CCDS11060.1
    UniProtKB/Swiss-Prot
    Q9H6Y7
    Related
    ENSP00000262482.6, ENST00000262482.11
    Conserved Domains (2) summary
    cd02123
    Location:20170
    PA_C_RZF_like; PA_C-RZF_ like: Protease-associated (PA) domain C_RZF-like. This group includes various PA domain-containing proteins similar to C-RZF (chicken embryo RING zinc finger) protein. These proteins contain a C3H2C3 RING finger. C-RZF is expressed in embryo ...
    cd16797
    Location:228273
    RING-H2_RNF167; RING finger, H2 subclass, found in RING finger protein 167 (RNF167) and similar proteins

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    4940092..4945222
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017024428.2XP_016879917.1  E3 ubiquitin-protein ligase RNF167 isoform X2

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