Format

Send to:

Choose Destination

HINFP histone H4 transcription factor [ Homo sapiens (human) ]

Gene ID: 25988, updated on 1-Jun-2020

Summary

Official Symbol
HINFPprovided by HGNC
Official Full Name
histone H4 transcription factorprovided by HGNC
Primary source
HGNC:HGNC:17850
See related
Ensembl:ENSG00000172273 MIM:607099
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
MIZF; HiNF-P; ZNF743
Summary
This gene encodes a transcription factor that interacts with methyl-CpG-binding protein-2 (MBD2), a component of the MeCP1 histone deacetylase (HDAC) complex, and plays a role in DNA methylation and transcription repression. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Aug 2011]
Expression
Ubiquitous expression in testis (RPKM 6.2), lymph node (RPKM 4.3) and 25 other tissues See more
Orthologs

Genomic context

See HINFP in Genome Data Viewer
Location:
11q23.3
Exon count:
15
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 11 NC_000011.10 (119121523..119136059)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (118992233..119005765)

Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984397 Neighboring gene C2CD2 like Neighboring gene ATP binding cassette subfamily G member 4 Neighboring gene NLR family member X1

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp434F162

Gene Ontology Provided by GOA

Function Evidence Code Pubs
DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA-binding transcription repressor activity, RNA polymerase II-specific IEA
Inferred from Electronic Annotation
more info
 
RNA polymerase II proximal promoter sequence-specific DNA binding IEA
Inferred from Electronic Annotation
more info
 
chromatin binding IEA
Inferred from Electronic Annotation
more info
 
enzyme binding IPI
Inferred from Physical Interaction
more info
PubMed 
histone binding IPI
Inferred from Physical Interaction
more info
PubMed 
metal ion binding IEA
Inferred from Electronic Annotation
more info
 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
PubMed 
Process Evidence Code Pubs
DNA damage checkpoint IMP
Inferred from Mutant Phenotype
more info
PubMed 
DNA repair IMP
Inferred from Mutant Phenotype
more info
PubMed 
G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
establishment of protein localization IMP
Inferred from Mutant Phenotype
more info
PubMed 
in utero embryonic development ISS
Inferred from Sequence or Structural Similarity
more info
 
myoblast differentiation IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
negative regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of transcription, DNA-templated IDA
Inferred from Direct Assay
more info
PubMed 
regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription involved in G1/S transition of mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
PubMed 
regulation of transcription, DNA-templated IMP
Inferred from Mutant Phenotype
more info
PubMed 
transcription, DNA-templated IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
Cajal body IDA
Inferred from Direct Assay
more info
PubMed 
NOT nucleolus IDA
Inferred from Direct Assay
more info
PubMed 
nucleoplasm IDA
Inferred from Direct Assay
more info
PubMed 
nucleus IDA
Inferred from Direct Assay
more info
PubMed 

General protein information

Preferred Names
histone H4 transcription factor
Names
MBD2 (methyl-CpG-binding protein)-interacting zinc finger protein
MBD2-interacting zinc finger 1
MBD2-interacting zinc finger protein
histone H4 gene-specific protein HiNF-P
histone nuclear factor P
methyl-CpG-binding protein 2-interacting zinc finger protein

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001243259.1NP_001230188.1  histone H4 transcription factor isoform 2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (3) uses an alternate acceptor splice site at the 3' terminal exon compared to variant 1. This results in a frame-shift, and a shorter isoform (2) with a distinct C-terminus compared to isoform 1.
    Source sequence(s)
    AK056362, AK301452, BC017234, DC326345
    Consensus CDS
    CCDS58188.1
    UniProtKB/Swiss-Prot
    Q9BQA5
    Related
    ENSP00000436815.1, ENST00000527410.3
    Conserved Domains (2) summary
    COG5236
    Location:171303
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:286306
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. NM_001351957.2NP_001338886.1  histone H4 transcription factor isoform 3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (4) encodes the longest isoform (3).
    Source sequence(s)
    AP002956, AP003391
    Conserved Domains (2) summary
    COG5236
    Location:194326
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:309329
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. NM_001351958.2NP_001338887.1  histone H4 transcription factor isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (5), as well as variants 1, 2, 6, and 7, encodes isoform 1.
    Source sequence(s)
    AP002956, AP003391
    Consensus CDS
    CCDS8414.1
    Conserved Domains (2) summary
    COG5236
    Location:171303
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:286306
    ZF_C2H2; C2H2 Zn finger [structural motif]
  4. NM_001351959.2NP_001338888.1  histone H4 transcription factor isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (6), as well as variants 1, 2, 5, and 7, encodes isoform 1.
    Source sequence(s)
    AP002956, AP003391
    Consensus CDS
    CCDS8414.1
    Conserved Domains (2) summary
    COG5236
    Location:171303
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:286306
    ZF_C2H2; C2H2 Zn finger [structural motif]
  5. NM_001351960.2NP_001338889.1  histone H4 transcription factor isoform 1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (7), as well as variants 1, 2, 5, and 6, encodes isoform 1.
    Source sequence(s)
    AP002956, AP003391
    Consensus CDS
    CCDS8414.1
    Conserved Domains (2) summary
    COG5236
    Location:171303
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:286306
    ZF_C2H2; C2H2 Zn finger [structural motif]
  6. NM_001351961.1NP_001338890.1  histone H4 transcription factor isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (8), as well as variant 9, encodes isoform 4.
    Source sequence(s)
    AL080201, AP002956, AP003391
    Conserved Domains (2) summary
    COG5236
    Location:171303
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:286306
    ZF_C2H2; C2H2 Zn finger [structural motif]
  7. NM_001351962.1NP_001338891.1  histone H4 transcription factor isoform 4

    Status: REVIEWED

    Description
    Transcript Variant: This variant (9), as well as variant 8, encodes isoform 4.
    Source sequence(s)
    AL080201, AP002956, AP003391
    Conserved Domains (2) summary
    COG5236
    Location:171303
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:286306
    ZF_C2H2; C2H2 Zn finger [structural motif]
  8. NM_001351963.2NP_001338892.1  histone H4 transcription factor isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (10), as well as variant 11, encodes isoform 5.
    Source sequence(s)
    AP002956, AP003391
    Conserved Domains (2) summary
    COG5236
    Location:2297
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:80100
    ZF_C2H2; C2H2 Zn finger [structural motif]
  9. NM_001351964.2NP_001338893.1  histone H4 transcription factor isoform 5

    Status: REVIEWED

    Description
    Transcript Variant: This variant (11), as well as variant 10, encodes isoform 5.
    Source sequence(s)
    AP002956, AP003391
    Conserved Domains (2) summary
    COG5236
    Location:2297
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:80100
    ZF_C2H2; C2H2 Zn finger [structural motif]
  10. NM_001351965.2NP_001338894.1  histone H4 transcription factor isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (12), as well as variants 13, 14, 15, 16, and 17, encodes isoform 6.
    Source sequence(s)
    AP002956, AP003391
    Conserved Domains (2) summary
    sd00017
    Location:3959
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:1031
    ZF_C2H2; C2H2 Zn finger [structural motif]
  11. NM_001351966.2NP_001338895.1  histone H4 transcription factor isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (13), as well as variants 12, 14, 15, 16, and 17, encodes isoform 6.
    Source sequence(s)
    AP002956, AP003391
    Conserved Domains (2) summary
    sd00017
    Location:3959
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:1031
    ZF_C2H2; C2H2 Zn finger [structural motif]
  12. NM_001351969.2NP_001338898.1  histone H4 transcription factor isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (14), as well as variants 12, 13, 15, 16, and 17, encodes isoform 6.
    Source sequence(s)
    AP002956, AP003391
    Conserved Domains (2) summary
    sd00017
    Location:3959
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:1031
    ZF_C2H2; C2H2 Zn finger [structural motif]
  13. NM_001351971.2NP_001338900.1  histone H4 transcription factor isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (15), as well as variants 12, 13, 14, 16, and 17, encodes isoform 6.
    Source sequence(s)
    AP002956, AP003391
    Conserved Domains (2) summary
    sd00017
    Location:3959
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:1031
    ZF_C2H2; C2H2 Zn finger [structural motif]
  14. NM_001351972.2NP_001338901.1  histone H4 transcription factor isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (16), as well as variants 12, 13, 14, 15, and 17, encodes isoform 6.
    Source sequence(s)
    AP002956, AP003391
    Conserved Domains (2) summary
    sd00017
    Location:3959
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:1031
    ZF_C2H2; C2H2 Zn finger [structural motif]
  15. NM_001351974.2NP_001338903.1  histone H4 transcription factor isoform 6

    Status: REVIEWED

    Description
    Transcript Variant: This variant (17), as well as variants 12, 13, 14, 15, and 16, encodes isoform 6.
    Source sequence(s)
    AP002956, AP003391
    Conserved Domains (2) summary
    sd00017
    Location:3959
    ZF_C2H2; C2H2 Zn finger [structural motif]
    sd00019
    Location:1031
    ZF_C2H2; C2H2 Zn finger [structural motif]
  16. NM_015517.5NP_056332.2  histone H4 transcription factor isoform 1

    See identical proteins and their annotated locations for NP_056332.2

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1), as well as variants 2, 5, 6, and 7, encodes isoform 1.
    Source sequence(s)
    AP002956, AP003391
    Consensus CDS
    CCDS8414.1
    UniProtKB/Swiss-Prot
    Q9BQA5
    UniProtKB/TrEMBL
    A0A024R3F5
    Conserved Domains (2) summary
    COG5236
    Location:171303
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:286306
    ZF_C2H2; C2H2 Zn finger [structural motif]
  17. NM_198971.3NP_945322.1  histone H4 transcription factor isoform 1

    See identical proteins and their annotated locations for NP_945322.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2), as well as variants 1, 5, 6, and 7, encodes isoform 1.
    Source sequence(s)
    AP002956, AP003391
    Consensus CDS
    CCDS8414.1
    UniProtKB/Swiss-Prot
    Q9BQA5
    UniProtKB/TrEMBL
    A0A024R3F5
    Related
    ENSP00000318085.3, ENST00000350777.7
    Conserved Domains (2) summary
    COG5236
    Location:171303
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:286306
    ZF_C2H2; C2H2 Zn finger [structural motif]

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000011.10 Reference GRCh38.p13 Primary Assembly

    Range
    119121523..119136059
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024448430.1XP_024304198.1  histone H4 transcription factor isoform X3

    Conserved Domains (2) summary
    COG5236
    Location:2297
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:80100
    ZF_C2H2; C2H2 Zn finger [structural motif]
  2. XM_011542744.2XP_011541046.1  histone H4 transcription factor isoform X1

    Conserved Domains (2) summary
    COG5236
    Location:185317
    COG5236; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
    sd00017
    Location:300320
    ZF_C2H2; C2H2 Zn finger [structural motif]
  3. XM_017017499.1XP_016872988.1  histone H4 transcription factor isoform X2

Support Center