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KRT23 keratin 23 [ Homo sapiens (human) ]

Gene ID: 25984, updated on 28-Jun-2020

Summary

Official Symbol
KRT23provided by HGNC
Official Full Name
keratin 23provided by HGNC
Primary source
HGNC:HGNC:6438
See related
Ensembl:ENSG00000108244 MIM:606194
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
K23; CK23; HAIK1
Summary
The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2013]
Expression
Biased expression in placenta (RPKM 45.8), skin (RPKM 39.5) and 7 other tissues See more
Orthologs

Genomic context

See KRT23 in Genome Data Viewer
Location:
17q21.2
Exon count:
10
Annotation release Status Assembly Chr Location
109.20200522 current GRCh38.p13 (GCF_000001405.39) 17 NC_000017.11 (40922696..40937646, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (39078948..39093895, complement)

Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105371777 Neighboring gene keratin 12 Neighboring gene keratin 20 Neighboring gene uncharacterized LOC107985072 Neighboring gene keratin 39 Neighboring gene keratin 40

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • MGC26158, DKFZp434G032

Gene Ontology Provided by GOA

Function Evidence Code Pubs
structural molecule activity IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
cornification TAS
Traceable Author Statement
more info
 
keratinization TAS
Traceable Author Statement
more info
 
Component Evidence Code Pubs
cytosol TAS
Traceable Author Statement
more info
 
intermediate filament IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
keratin, type I cytoskeletal 23
Names
CK-23
cytokeratin 23
histone deacetylase inducible keratin 23
hyperacetylation-inducible type I keratin
keratin 23 (histone deacetylase inducible)
keratin 23, type I
type I intermediate filament cytokeratin

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

  1. NG_012287.1 RefSeqGene

    Range
    4942..19889
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001282433.2NP_001269362.1  keratin, type I cytoskeletal 23 isoform 2

    See identical proteins and their annotated locations for NP_001269362.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR and has multiple coding region differences, compared to variant 1. These differences cause translation initiation at a downstream AUG and result in an isoform (2) with a shorter N-terminus, compared to isoform 1.
    Source sequence(s)
    AK302109, CV373638
    Consensus CDS
    CCDS62182.1
    UniProtKB/Swiss-Prot
    Q9C075
    Related
    ENSP00000414056.3, ENST00000436344.7
    Conserved Domains (1) summary
    pfam00038
    Location:3243
    Filament; Intermediate filament protein
  2. NM_015515.5NP_056330.3  keratin, type I cytoskeletal 23 isoform 1

    See identical proteins and their annotated locations for NP_056330.3

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the larger isoform (1)
    Source sequence(s)
    AA649738, AC004231, BC028356, DA846104
    Consensus CDS
    CCDS11380.1
    UniProtKB/Swiss-Prot
    Q9C075
    UniProtKB/TrEMBL
    A0A024R1X9, Q8TC04
    Related
    ENSP00000209718.3, ENST00000209718.8
    Conserved Domains (1) summary
    pfam00038
    Location:71380
    Filament; Intermediate filament protein

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000017.11 Reference GRCh38.p13 Primary Assembly

    Range
    40922696..40937646 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_005257200.5XP_005257257.1  keratin, type I cytoskeletal 23 isoform X1

    See identical proteins and their annotated locations for XP_005257257.1

    UniProtKB/Swiss-Prot
    Q9C075
    Conserved Domains (1) summary
    pfam00038
    Location:3243
    Filament; Intermediate filament protein
  2. XM_011524595.2XP_011522897.1  keratin, type I cytoskeletal 23 isoform X1

    See identical proteins and their annotated locations for XP_011522897.1

    UniProtKB/Swiss-Prot
    Q9C075
    Conserved Domains (1) summary
    pfam00038
    Location:3243
    Filament; Intermediate filament protein

Reference GRCh38.p13 ALT_REF_LOCI_1

Genomic

  1. NW_003871091.1 Reference GRCh38.p13 ALT_REF_LOCI_1

    Range
    71968..86914 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_173213.1: Suppressed sequence

    Description
    NM_173213.1: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript.
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