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UNC50 unc-50 inner nuclear membrane RNA binding protein [ Homo sapiens (human) ]

Gene ID: 25972, updated on 10-Oct-2023

Summary

Official Symbol
UNC50provided by HGNC
Official Full Name
unc-50 inner nuclear membrane RNA binding proteinprovided by HGNC
Primary source
HGNC:HGNC:16046
See related
Ensembl:ENSG00000115446 MIM:617826; AllianceGenome:HGNC:16046
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
URP; GMH1; UNCL; HSD23; PDLs22
Summary
Predicted to enable RNA binding activity. Predicted to be involved in protein localization to cell surface. Predicted to be located in Golgi apparatus and nuclear inner membrane. Predicted to be integral component of Golgi membrane. [provided by Alliance of Genome Resources, Apr 2022]
Expression
Ubiquitous expression in thyroid (RPKM 28.7), testis (RPKM 24.9) and 25 other tissues See more
Orthologs
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Genomic context

See UNC50 in Genome Data Viewer
Location:
2q11.2
Exon count:
6
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (98608589..98618515)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (99066916..99076837)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (99225052..99234978)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11800 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16259 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16260 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:99079757-99080272 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16261 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16262 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16263 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:99082317-99082881 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11801 Neighboring gene inositol polyphosphate-4-phosphatase type I A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16264 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16265 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16266 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16267 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:99136086-99136586 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:99136587-99137087 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16268 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:99170837-99171337 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:99176784-99176955 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:99190711-99190893 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:99200423-99200924 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:99209219-99209372 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 16269 Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:99224127-99225116 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11802 Neighboring gene cytochrome c oxidase assembly factor 5 Neighboring gene alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A Neighboring gene uncharacterized LOC124906050 Neighboring gene YWHAQ pseudogene 5

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Clone Names

  • DKFZp564G0222

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in protein localization to cell surface ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
 
located_in nuclear inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
protein unc-50 homolog
Names
geal-6 membrane-associated high-copy suppressor 1
periodontal ligament-specific protein 22
protein GMH1 homolog
unc-50 related
unc-50-like protein
uncoordinated-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330353.2NP_001317282.1  protein unc-50 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC010134, AC064860
    Conserved Domains (1) summary
    pfam05216
    Location:32226
    UNC-50; UNC-50 family
  2. NM_001330354.2NP_001317283.1  protein unc-50 homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC010134, AC064860
    Consensus CDS
    CCDS82485.1
    UniProtKB/TrEMBL
    J3KQ47
    Related
    ENSP00000386466.1, ENST00000409347.5
    Conserved Domains (1) summary
    pfam05216
    Location:49270
    UNC-50; UNC-50 family
  3. NM_014044.7NP_054763.2  protein unc-50 homolog isoform 3

    See identical proteins and their annotated locations for NP_054763.2

    Status: VALIDATED

    Source sequence(s)
    AK222599, BC091481
    Consensus CDS
    CCDS2035.1
    UniProtKB/Swiss-Prot
    D3DVH4, Q53HI1, Q53S98, Q53TD6, Q5U5U2, Q6X7B9, Q9UQF4, Q9Y4S6
    UniProtKB/TrEMBL
    A0A0S2Z612
    Related
    ENSP00000350409.2, ENST00000357765.7
    Conserved Domains (1) summary
    pfam05216
    Location:34255
    UNC-50; UNC-50 family

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

    Range
    98608589..98618515
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006712403.4XP_006712466.1  protein unc-50 homolog isoform X1

    Conserved Domains (1) summary
    pfam05216
    Location:49243
    UNC-50; UNC-50 family

Alternate T2T-CHM13v2.0

Genomic

  1. NC_060926.1 Alternate T2T-CHM13v2.0

    Range
    99066916..99076837
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_054341317.1XP_054197292.1  protein unc-50 homolog isoform X2