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UNC50 unc-50 inner nuclear membrane RNA binding protein [ Homo sapiens (human) ]

Gene ID: 25972, updated on 5-Jan-2022

Summary

Official Symbol
UNC50provided by HGNC
Official Full Name
unc-50 inner nuclear membrane RNA binding proteinprovided by HGNC
Primary source
HGNC:HGNC:16046
See related
Ensembl:ENSG00000115446 MIM:617826
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
URP; GMH1; UNCL; HSD23; PDLs22
Summary
Predicted to enable RNA binding activity. Predicted to be involved in protein localization to cell surface. Predicted to be located in Golgi apparatus and nuclear inner membrane. Predicted to be integral component of Golgi membrane. [provided by Alliance of Genome Resources, Nov 2021]
Expression
Ubiquitous expression in thyroid (RPKM 28.7), testis (RPKM 24.9) and 25 other tissues See more
Orthologs
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Genomic context

See UNC50 in Genome Data Viewer
Location:
2q11.2
Exon count:
6
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (98608589..98618515)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (99225052..99234978)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene inositol polyphosphate-4-phosphatase type I A Neighboring gene cytochrome c oxidase assembly factor 5 Neighboring gene alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A Neighboring gene YWHAQ pseudogene 5 Neighboring gene Sharpr-MPRA regulatory region 13812

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp564G0222

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding ISS
Inferred from Sequence or Structural Similarity
more info
 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in protein localization to cell surface ISS
Inferred from Sequence or Structural Similarity
more info
 
Component Evidence Code Pubs
is_active_in integral component of Golgi membrane IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nuclear inner membrane ISS
Inferred from Sequence or Structural Similarity
more info
 

General protein information

Preferred Names
protein unc-50 homolog
Names
geal-6 membrane-associated high-copy suppressor 1
periodontal ligament-specific protein 22
protein GMH1 homolog
unc-50 related
unc-50-like protein
uncoordinated-like protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001330353.2NP_001317282.1  protein unc-50 homolog isoform 2

    Status: VALIDATED

    Source sequence(s)
    AC010134, AC064860
    Conserved Domains (1) summary
    pfam05216
    Location:32226
    UNC-50; UNC-50 family
  2. NM_001330354.2NP_001317283.1  protein unc-50 homolog isoform 1

    Status: VALIDATED

    Source sequence(s)
    AC010134, AC064860
    Consensus CDS
    CCDS82485.1
    UniProtKB/TrEMBL
    J3KQ47
    Related
    ENSP00000386466.1, ENST00000409347.5
    Conserved Domains (1) summary
    pfam05216
    Location:49270
    UNC-50; UNC-50 family
  3. NM_014044.7NP_054763.2  protein unc-50 homolog isoform 3

    See identical proteins and their annotated locations for NP_054763.2

    Status: VALIDATED

    Source sequence(s)
    AK222599, BC091481
    Consensus CDS
    CCDS2035.1
    UniProtKB/Swiss-Prot
    Q53HI1
    UniProtKB/TrEMBL
    A0A0S2Z612
    Related
    ENSP00000350409.2, ENST00000357765.7
    Conserved Domains (1) summary
    pfam05216
    Location:34255
    UNC-50; UNC-50 family

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    98608589..98618515
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_006712403.3XP_006712466.1  protein unc-50 homolog isoform X1

    Conserved Domains (1) summary
    pfam05216
    Location:49243
    UNC-50; UNC-50 family
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