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PNISR PNN interacting serine and arginine rich protein [ Homo sapiens (human) ]

Gene ID: 25957, updated on 17-Jun-2019

Summary

Official Symbol
PNISRprovided by HGNC
Official Full Name
PNN interacting serine and arginine rich proteinprovided by HGNC
Primary source
HGNC:HGNC:21222
See related
Ensembl:ENSG00000132424 MIM:616653
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SFRS18; HSPC306; SRrp130; C6orf111; bA98I9.2
Expression
Ubiquitous expression in lymph node (RPKM 25.8), spleen (RPKM 24.5) and 25 other tissues See more
Orthologs

Genomic context

See PNISR in Genome Data Viewer
Location:
6q16.2
Exon count:
14
Annotation release Status Assembly Chr Location
109.20190607 current GRCh38.p13 (GCF_000001405.39) 6 NC_000006.12 (99398050..99426306, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (99846534..99873263, complement)

Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene failed axon connections homolog, metaxin like GST domain containing Neighboring gene coenzyme Q3, methyltransferase Neighboring gene uncharacterized LOC101927365 Neighboring gene thiosulfate sulfurtransferase like domain containing 3 Neighboring gene ubiquitin specific peptidase 45 Neighboring gene cyclin C

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ14752, FLJ14853, FLJ14992, FLJ90147, MGC104269, DKFZp564B0769

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
Component Evidence Code Pubs
cytosol IDA
Inferred from Direct Assay
more info
 
nuclear speck IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
nuclear speck IDA
Inferred from Direct Assay
more info
 
presynaptic active zone IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
arginine/serine-rich protein PNISR
Names
PNN-interacting serine/arginine-rich protein
SR-related protein
SR-rich protein
serine-arginine-rich-splicing regulatory protein 130
splicing factor, arginine/serine-rich 130
splicing factor, arginine/serine-rich 18

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001322405.2NP_001309334.1  arginine/serine-rich protein PNISR isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4 and 5 all encode isoform a.
    Source sequence(s)
    AL513550, BC064413, BM893682, DA326969
    Consensus CDS
    CCDS5043.1
    UniProtKB/Swiss-Prot
    Q8TF01
    Conserved Domains (1) summary
    pfam15996
    Location:223380
    PNISR; Arginine/serine-rich protein PNISR
  2. NM_001322406.2NP_001309335.1  arginine/serine-rich protein PNISR isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4 and 5 all encode isoform a.
    Source sequence(s)
    AL513550, BC012780, BM893682, DA326969, DB186090
    Consensus CDS
    CCDS5043.1
    UniProtKB/Swiss-Prot
    Q8TF01
    UniProtKB/TrEMBL
    Q6PJQ9
    Related
    ENSP00000496842.1, ENST00000647811.1
    Conserved Domains (1) summary
    pfam15996
    Location:223380
    PNISR; Arginine/serine-rich protein PNISR
  3. NM_001322408.2NP_001309337.1  arginine/serine-rich protein PNISR isoform a

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4 and 5 all encode isoform a.
    Source sequence(s)
    AL513550, BC012780, BM893682, BX648520, DA326969
    Consensus CDS
    CCDS5043.1
    UniProtKB/Swiss-Prot
    Q8TF01
    UniProtKB/TrEMBL
    Q6PJQ9
    Conserved Domains (1) summary
    pfam15996
    Location:223380
    PNISR; Arginine/serine-rich protein PNISR
  4. NM_001322410.1NP_001309339.1  arginine/serine-rich protein PNISR isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (6) splices out a portion of the 3' terminal exon, resulting in an alternate 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct and longer C-terminus, compared to isoform a. Variants 6, 7 and 8 all encode isoform b.
    Source sequence(s)
    AJ420559, AL513550, BC012780, BM893682, BQ000404, DA326969
    UniProtKB/TrEMBL
    Q6PJQ9
    Conserved Domains (1) summary
    pfam15996
    Location:223380
    PNISR; Arginine/serine-rich protein PNISR
  5. NM_001322412.1NP_001309341.1  arginine/serine-rich protein PNISR isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (7) differs in the 5' UTR and splices out a portion of the 3' terminal exon, resulting in an alternate 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct and longer C-terminus, compared to isoform a. Variants 6, 7 and 8 all encode isoform b.
    Source sequence(s)
    AJ420559, AL513550, BC007791, BC012780, BM893682, BQ000404, DA326969
    UniProtKB/Swiss-Prot
    Q8TF01
    UniProtKB/TrEMBL
    Q6PJQ9
    Conserved Domains (1) summary
    pfam15996
    Location:223380
    PNISR; Arginine/serine-rich protein PNISR
  6. NM_001322413.1NP_001309342.1  arginine/serine-rich protein PNISR isoform b

    Status: VALIDATED

    Description
    Transcript Variant: This variant (8) differs in the 5' UTR and splices out a portion of the 3' terminal exon, resulting in an alternate 3' coding region, compared to variant 1. The encoded isoform (b) has a distinct and longer C-terminus, compared to isoform a. Variants 6, 7 and 8 all encode isoform b.
    Source sequence(s)
    AF314184, AK074628, AL513550, BM893682, BQ000404, DA326969
    UniProtKB/Swiss-Prot
    Q8TF01
    Conserved Domains (1) summary
    pfam15996
    Location:223380
    PNISR; Arginine/serine-rich protein PNISR
  7. NM_001322414.2NP_001309343.1  arginine/serine-rich protein PNISR isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (9) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a. Both variants 9 and 10 encode isoform c.
    Source sequence(s)
    AL513550, AW081113, BC012780, BM893682, DA326969
    UniProtKB/TrEMBL
    Q6PJQ9
    Conserved Domains (1) summary
    pfam15996
    Location:223367
    PNISR; Arginine/serine-rich protein PNISR
  8. NM_001322415.2NP_001309344.1  arginine/serine-rich protein PNISR isoform c

    Status: VALIDATED

    Description
    Transcript Variant: This variant (10) differs in the 5' UTR and lacks an alternate in-frame exon in the 3' coding region, compared to variant 1, resulting in an isoform (c) that is shorter than isoform a. Both variants 9 and 10 encode isoform c.
    Source sequence(s)
    AK074628, AL513550, AW081113, BM893682
    UniProtKB/Swiss-Prot
    Q8TF01
    Conserved Domains (1) summary
    pfam15996
    Location:223367
    PNISR; Arginine/serine-rich protein PNISR
  9. NM_001322416.1NP_001309345.1  arginine/serine-rich protein PNISR isoform d

    Status: VALIDATED

    Description
    Transcript Variant: This variant (11) uses an alternate splice site in the 3' terminal exon, resulting in an alternate 3' coding region, compared to variant 1. The encoded isoform (d) has a distinct C-terminus and is shorter than isoform a.
    Source sequence(s)
    AA626029, AL513550, BC012780, BM893682, DA326969
    UniProtKB/TrEMBL
    Q6PJQ9
    Conserved Domains (1) summary
    pfam15996
    Location:223380
    PNISR; Arginine/serine-rich protein PNISR
  10. NM_001322417.2NP_001309346.1  arginine/serine-rich protein PNISR isoform e

    Status: VALIDATED

    Description
    Transcript Variant: This variant (12) lacks several 3' exons but contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (e) has a distinct C-terminus and is significantly shorter than isoform a.
    Source sequence(s)
    BC012780, BM674898, BU675213, BX648520, DA326969, DA948286, DB108627
    UniProtKB/TrEMBL
    Q6PJQ9
  11. NM_001322418.2NP_001309347.1  arginine/serine-rich protein PNISR isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (13) differs in the 5' UTR and lacks several 3' exons but contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (f) has a distinct C-terminus and is significantly shorter than isoform a. Both variants 13 and 14 encode isoform f.
    Source sequence(s)
    BM674898, BU675213, BX648520, DA326969, DA948286, DB108627
    UniProtKB/TrEMBL
    H0UI36
  12. NM_001322419.2NP_001309348.1  arginine/serine-rich protein PNISR isoform f

    Status: VALIDATED

    Description
    Transcript Variant: This variant (14) lacks several 3' exons but contains an alternate 3' terminal exon, and it thus differs in the 3' coding region and 3' UTR, compared to variant 1. The encoded isoform (f) has a distinct C-terminus and is significantly shorter than isoform a. Both variants 13 and 14 encode isoform f.
    Source sequence(s)
    BC107700, BM674898, BU675213, BX648520, DA326969, DA948286, DB108627
    UniProtKB/TrEMBL
    H0UI36, Q3B7B6
  13. NM_015491.2NP_056306.1  arginine/serine-rich protein PNISR isoform a

    See identical proteins and their annotated locations for NP_056306.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2, 3, 4 and 5 all encode isoform a.
    Source sequence(s)
    AK074628, AL513550, BM893682, DA326969
    Consensus CDS
    CCDS5043.1
    UniProtKB/Swiss-Prot
    Q8TF01
    Related
    ENSP00000387997.1, ENST00000438806.5
    Conserved Domains (1) summary
    pfam15996
    Location:223380
    PNISR; Arginine/serine-rich protein PNISR
  14. NM_032870.4NP_116259.2  arginine/serine-rich protein PNISR isoform a

    See identical proteins and their annotated locations for NP_116259.2

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) encodes isoform a. Variants 1, 2, 3, 4 and 5 all encode the same isoform.
    Source sequence(s)
    AL513550, BC012780, BM893682, DA326969
    Consensus CDS
    CCDS5043.1
    UniProtKB/Swiss-Prot
    Q8TF01
    UniProtKB/TrEMBL
    Q6PJQ9
    Related
    ENSP00000358242.5, ENST00000369239.10
    Conserved Domains (1) summary
    pfam15996
    Location:223380
    PNISR; Arginine/serine-rich protein PNISR

RNA

  1. NR_136326.1 RNA Sequence

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15) lacks an alternate exon in the 5' region and retains an intron in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
    Source sequence(s)
    AK027658, AK074628, AL513550, BM893682, DA326969, DA568256

RefSeqs of Annotated Genomes: Homo sapiens Annotation Release 109

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000006.12 Reference GRCh38.p13 Primary Assembly

    Range
    99398050..99426306 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_024446397.1XP_024302165.1  arginine/serine-rich protein PNISR isoform X2

    Conserved Domains (1) summary
    pfam15996
    Location:286430
    PNISR; Arginine/serine-rich protein PNISR
  2. XM_005266912.4XP_005266969.3  arginine/serine-rich protein PNISR isoform X1

    Conserved Domains (1) summary
    pfam15996
    Location:286443
    PNISR; Arginine/serine-rich protein PNISR
  3. XM_017010713.1XP_016866202.1  arginine/serine-rich protein PNISR isoform X4

    Conserved Domains (1) summary
    pfam15996
    Location:128285
    PNISR; Arginine/serine-rich protein PNISR
  4. XM_017010712.1XP_016866201.1  arginine/serine-rich protein PNISR isoform X4

    Conserved Domains (1) summary
    pfam15996
    Location:128285
    PNISR; Arginine/serine-rich protein PNISR
  5. XM_017010711.1XP_016866200.1  arginine/serine-rich protein PNISR isoform X3

    Conserved Domains (1) summary
    pfam15996
    Location:223367
    PNISR; Arginine/serine-rich protein PNISR
  6. XM_017010710.2XP_016866199.1  arginine/serine-rich protein PNISR isoform X3

    Conserved Domains (1) summary
    pfam15996
    Location:223367
    PNISR; Arginine/serine-rich protein PNISR
  7. XM_024446398.1XP_024302166.1  arginine/serine-rich protein PNISR isoform X4

    Conserved Domains (1) summary
    pfam15996
    Location:128285
    PNISR; Arginine/serine-rich protein PNISR
  8. XM_024446399.1XP_024302167.1  arginine/serine-rich protein PNISR isoform X5

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