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SEC31B SEC31 homolog B, COPII coat complex component [ Homo sapiens (human) ]

Gene ID: 25956, updated on 23-Nov-2023


Official Symbol
SEC31Bprovided by HGNC
Official Full Name
SEC31 homolog B, COPII coat complex componentprovided by HGNC
Primary source
See related
Ensembl:ENSG00000075826 MIM:610258; AllianceGenome:HGNC:23197
Gene type
protein coding
RefSeq status
Homo sapiens
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
SEC31L2; SEC31B-1
This gene encodes a protein of unknown function. The protein has moderate similarity to rat VAP1 protein which is an endosomal membrane-associated protein, containing a putative Ca2+/calmodulin-dependent kinase II phosphorylation site. [provided by RefSeq, Jul 2008]
Ubiquitous expression in testis (RPKM 7.5), lymph node (RPKM 6.5) and 24 other tissues See more
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Genomic context

See SEC31B in Genome Data Viewer
Exon count:
Annotation release Status Assembly Chr Location
RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (100486647..100519861, complement)
RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (101369754..101402965, complement)
105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (102246404..102279618, complement)

Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:102132955-102133524 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:102133525-102134092 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:102134093-102134662 Neighboring gene oligodendrocyte maturation-associated long intergenic non-coding RNA Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:102214151-102214652 Neighboring gene Wnt family member 8B Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:102242041-102242696 Neighboring gene VISTA enhancer hs1006 Neighboring gene MPRA-validated peak1070 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3893 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:102289335-102289917 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3894 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3895 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3896 Neighboring gene NADH:ubiquinone oxidoreductase subunit B8 Neighboring gene hypoxia inducible factor 1 subunit alpha inhibitor

Genomic regions, transcripts, and products


  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018


GeneRIFs: Gene References Into Functions

What's a GeneRIF?


EBI GWAS Catalog

Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
EBI GWAS Catalog
Genome-wide association study identifies novel loci associated with concentrations of four plasma phospholipid fatty acids in the de novo lipogenesis pathway: results from the Cohorts for Heart and Aging Research in Genomic Epidemiology (CHARGE) consortiu
EBI GWAS Catalog

Pathways from PubChem


Products Interactant Other Gene Complex Source Pubs Description

General gene information


Potential readthrough

Included gene: NDUFB8

Clone Names

  • DKFZp434M183

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables structural molecule activity IBA
Inferred from Biological aspect of Ancestor
more info
Process Evidence Code Pubs
involved_in COPII-coated vesicle cargo loading IBA
Inferred from Biological aspect of Ancestor
more info
involved_in endoplasmic reticulum organization IBA
Inferred from Biological aspect of Ancestor
more info
involved_in intracellular protein transport IBA
Inferred from Biological aspect of Ancestor
more info
Component Evidence Code Pubs
part_of COPII vesicle coat IBA
Inferred from Biological aspect of Ancestor
more info
is_active_in endoplasmic reticulum exit site IBA
Inferred from Biological aspect of Ancestor
more info
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
part_of vesicle coat IDA
Inferred from Direct Assay
more info

General protein information

Preferred Names
protein transport protein Sec31B
SEC31 homolog B, COPII coating complex component
SEC31-like 2
SEC31-like protein 2
SEC31-related protein B
secretory pathway component Sec31B-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015490.4NP_056305.1  protein transport protein Sec31B

    See identical proteins and their annotated locations for NP_056305.1

    Status: REVIEWED

    Source sequence(s)
    AF274863, AL133352, BC034946, BM719543
    Consensus CDS
    B7ZM75, Q6MZS3, Q86UF0, Q9NQW1, Q9Y4Q8
    ENSP00000359370.3, ENST00000370345.8
    Conserved Domains (5) summary
    WD40; WD40 repeat [General function prediction only]
    MISS; MAPK-interacting and spindle-stabilizing protein-like
    7WD40; WD40 repeat [structural motif]
    WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
    ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly


  1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

    100486647..100519861 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0


  1. NC_060934.1 Alternate T2T-CHM13v2.0

    101369754..101402965 complement
    GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

  1. NM_198138.1: Suppressed sequence

    NM_198138.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate and lacks homolog support.