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pad-2 GDP-fucose protein O-fucosyltransferase 2 [ Caenorhabditis elegans ]

Gene ID: 259529, updated on 2-Dec-2025
Official Symbol
pad-2
Official Full Name
GDP-fucose protein O-fucosyltransferase 2
Primary source
WormBase:WBGene00010757
Locus tag
CELE_K10G9.3
See related
AllianceGenome:WB:WBGene00010757
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables peptide-O-fucosyltransferase activity. Involved in protein O-linked fucosylation. Predicted to be located in Golgi apparatus and endoplasmic reticulum. Is expressed in several structures, including excretory cell; hermaphrodite gonad; intestine; nervous system; and rectal gland cell. Used to study Down syndrome. Orthologous to human POFUT2 (protein O-fucosyltransferase 2). [provided by Alliance of Genome Resources, Jul 2025]
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See pad-2 in Genome Data Viewer
Location:
chromosome: III
Exon count:
5
Sequence:
Chromosome: III; NC_003281.10 (10279126..10281575)

Chromosome III - NC_003281.10Genomic Context describing neighboring genes Neighboring gene BBSome complex member bbs-5 Neighboring gene PH domain-containing protein Neighboring gene Connector enhancer of kinase suppressor of ras Neighboring gene Bestrophin homolog Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene ncRNA

Genomic Sequence:
NC_003281.10

Go to nucleotide: Graphics FASTA GenBank

Related articles in PubMed

  1. The Essential Role of Water Molecules in the Reaction Mechanism of Protein O-Fucosyltransferase 2. Sanz-Martínez I, et al. Angew Chem Int Ed Engl, 2022 Nov 25. PMID 36260536, Free PMC Article
  2. A proactive role of water molecules in acceptor recognition by protein O-fucosyltransferase 2. Valero-González J, et al. Nat Chem Biol, 2016 Apr. PMID 26854667, Free PMC Article
  3. Identification and characterization of abeta1,3-glucosyltransferase that synthesizes the Glc-beta1,3-Fuc disaccharide on thrombospondin type 1 repeats. Kozma K, et al. J Biol Chem, 2006 Dec 1. PMID 17032646
  4. The Caenorhabditis elegans ortholog of C21orf80, a potential new protein O-fucosyltransferase, is required for normal development. Menzel O, et al. Genomics, 2004 Aug. PMID 15233996
  5. Systematic Functional Characterization of Human 21st Chromosome Orthologs in Caenorhabditis elegans. Nordquist SK, et al. G3 (Bethesda), 2018 Mar 2. PMID 29367452, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. pad-2 is required for normal development
    Title: The Caenorhabditis elegans ortholog of C21orf80, a potential new protein O-fucosyltransferase, is required for normal development.
Submit: New GeneRIF Correction

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables glycosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptide-O-fucosyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables peptide-O-fucosyltransferase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables peptide-O-fucosyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables peptide-O-fucosyltransferase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in fucose metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in protein O-linked glycosylation via fucose IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in protein O-linked glycosylation via fucose IEA
Inferred from Electronic Annotation
more info
  
involved_in protein O-linked glycosylation via fucose ISS
Inferred from Sequence or Structural Similarity
more info
  
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
Preferred Names
GDP-fucose protein O-fucosyltransferase 2
NP_001255069.1
  • Confirmed by transcript evidence
NP_001255070.1
  • Confirmed by transcript evidence

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003281.10 Reference assembly

    Range
    10279126..10281575
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001268140.3 → NP_001255069.1  GDP-fucose protein O-fucosyltransferase 2

    See identical proteins and their annotated locations for NP_001255069.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G1K0W1
    Conserved Domains (2) summary
    cd11298
    Location:43 → 411
    O-FucT-2; GDP-fucose protein O-fucosyltransferase 2
    pfam10250
    Location:53 → 404
    O-FucT; GDP-fucose protein O-fucosyltransferase

  2. NM_001268141.4 → NP_001255070.1  GDP-fucose protein O-fucosyltransferase 2

    See identical proteins and their annotated locations for NP_001255070.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q8WR51
    Conserved Domains (2) summary
    cd11298
    Location:43 → 409
    O-FucT-2; GDP-fucose protein O-fucosyltransferase 2
    pfam10250
    Location:53 → 402
    O-FucT; GDP-fucose protein O-fucosyltransferase
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q8WR51.1

Gene LinkOut

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