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SYF2 SYF2 pre-mRNA splicing factor [ Homo sapiens (human) ]

Gene ID: 25949, updated on 23-Nov-2021

Summary

Official Symbol
SYF2provided by HGNC
Official Full Name
SYF2 pre-mRNA splicing factorprovided by HGNC
Primary source
HGNC:HGNC:19824
See related
Ensembl:ENSG00000117614 MIM:607090
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
P29; CBPIN; NTC31; fSAP29
Summary
This gene encodes a nuclear protein that interacts with cyclin D-type binding-protein 1, which is thought to be a cell cycle regulator at the G1/S transition. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]
Expression
Ubiquitous expression in bone marrow (RPKM 39.9), ovary (RPKM 37.8) and 25 other tissues See more
Orthologs
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Genomic context

See SYF2 in Genome Data Viewer
Location:
1p36.11
Exon count:
7
Annotation release Status Assembly Chr Location
109.20211119 current GRCh38.p13 (GCF_000001405.39) 1 NC_000001.11 (25222276..25232502, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (25548767..25558993, complement)

Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 2793 Neighboring gene IFITM3 pseudogene 7 Neighboring gene uncharacterized LOC105376882 Neighboring gene arginine and serine rich protein 1 Neighboring gene Rh blood group D antigen Neighboring gene succinate dehydrogenase complex subunit D pseudogene 6

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp564O2082

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables RNA binding HDA PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
Process Evidence Code Pubs
involved_in embryonic organ development IEA
Inferred from Electronic Annotation
more info
 
involved_in gastrulation IEA
Inferred from Electronic Annotation
more info
 
involved_in in utero embryonic development IEA
Inferred from Electronic Annotation
more info
 
involved_in mRNA splicing, via spliceosome IC
Inferred by Curator
more info
PubMed 
involved_in mRNA splicing, via spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
involved_in mitotic G2 DNA damage checkpoint signaling IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell population proliferation IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
part_of Prp19 complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of U2-type catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
part_of catalytic step 2 spliceosome IDA
Inferred from Direct Assay
more info
PubMed 
located_in nuclear speck IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 
part_of post-mRNA release spliceosomal complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

General protein information

Preferred Names
pre-mRNA-splicing factor SYF2
Names
CCNDBP1 interactor
GCIP-interacting protein p29
SYF2 homolog, RNA splicing factor
functional spliceosome-associated protein 29

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_015484.5NP_056299.1  pre-mRNA-splicing factor SYF2 isoform 1

    See identical proteins and their annotated locations for NP_056299.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (1) encodes the longer isoform (1).
    Source sequence(s)
    AL031432, BC010862, DR155437
    Consensus CDS
    CCDS259.1
    UniProtKB/Swiss-Prot
    O95926
    Related
    ENSP00000236273.4, ENST00000236273.9
    Conserved Domains (1) summary
    pfam08231
    Location:90238
    SYF2; SYF2 splicing factor
  2. NM_207170.4NP_997053.1  pre-mRNA-splicing factor SYF2 isoform 2

    See identical proteins and their annotated locations for NP_997053.1

    Status: REVIEWED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon, compared to variant 1, but maintains the reading frame. The resulting protein (isoform 2) is shorter than isoform 1 and lacks both bipartite nuclear localization signals found in isoform 1.
    Source sequence(s)
    AL031432, BC010862, CV806249, DR155437
    Consensus CDS
    CCDS258.1
    UniProtKB/Swiss-Prot
    O95926
    Related
    ENSP00000346330.3, ENST00000354361.3
    Conserved Domains (1) summary
    pfam08231
    Location:48196
    SYF2; SYF2 splicing factor

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20211119

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000001.11 Reference GRCh38.p13 Primary Assembly

    Range
    25222276..25232502 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
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