Format

Send to:

Choose Destination

FAM98A family with sequence similarity 98 member A [ Homo sapiens (human) ]

Gene ID: 25940, updated on 3-May-2020

Summary

Official Symbol
FAM98Aprovided by HGNC
Official Full Name
family with sequence similarity 98 member Aprovided by HGNC
Primary source
HGNC:HGNC:24520
See related
Ensembl:ENSG00000119812
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Expression
Broad expression in testis (RPKM 38.2), brain (RPKM 16.8) and 24 other tissues See more
Orthologs

Genomic context

See FAM98A in Genome Data Viewer
Location:
2p22.3
Exon count:
8
Annotation release Status Assembly Chr Location
109.20200228 current GRCh38.p13 (GCF_000001405.39) 2 NC_000002.12 (33583660..33599362, complement)
105 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (33808727..33824362, complement)

Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene microRNA 4430 Neighboring gene RAS guanyl releasing protein 3 Neighboring gene RASGRP3 antisense RNA 1 Neighboring gene uncharacterized LOC105374455 Neighboring gene ATPase H+ transporting V0 subunit e1 pseudogene 3 Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 61

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

Phenotypes

NHGRI GWAS Catalog

Description
Genome-wide association study of young-onset hypertension in the Han Chinese population of Taiwan.
NHGRI GWA Catalog

HIV-1 interactions

Protein interactions

Protein Gene Interaction Pubs
Tat tat HIV-1 Tat is identified to have a physical interaction with family with sequence similarity 98, member A (FAM98A) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

Go to the HIV-1, Human Interaction Database

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • DKFZp564F0522, DKFZp686O03192

Gene Ontology Provided by GOA

Function Evidence Code Pubs
RNA binding HDA PubMed 
protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
protein methyltransferase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
Process Evidence Code Pubs
lysosome localization ISS
Inferred from Sequence or Structural Similarity
more info
 
positive regulation of cell proliferation IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
PubMed 
positive regulation of ruffle assembly ISS
Inferred from Sequence or Structural Similarity
more info
 
protein methylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
Component Evidence Code Pubs
tRNA-splicing ligase complex IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 

NCBI Reference Sequences (RefSeq)

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001304538.1NP_001291467.1  protein FAM98A isoform 2

    See identical proteins and their annotated locations for NP_001291467.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) lacks an alternate exon, resulting in a distinct 5' UTR and the use of a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.
    Source sequence(s)
    AC017050, AK300023, BC060860, DA310995
    UniProtKB/TrEMBL
    B4DT23, I6L9E8
    Conserved Domains (1) summary
    pfam10239
    Location:2132
    DUF2465; Protein of unknown function (DUF2465)
  2. NM_015475.5NP_056290.3  protein FAM98A isoform 1

    See identical proteins and their annotated locations for NP_056290.3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
    Source sequence(s)
    AC017050, BC060860, BC136768, DA310995
    Consensus CDS
    CCDS33179.1
    UniProtKB/Swiss-Prot
    Q8NCA5
    UniProtKB/TrEMBL
    I6L9E8
    Related
    ENSP00000238823.8, ENST00000238823.13
    Conserved Domains (1) summary
    pfam10239
    Location:11327
    DUF2465; Protein of unknown function (DUF2465)

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000002.12 Reference GRCh38.p13 Primary Assembly

    Range
    33583660..33599362 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)
Support Center