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WWTR1 WW domain containing transcription regulator 1 [ Homo sapiens (human) ]

Gene ID: 25937, updated on 6-Sep-2021

Summary

Official Symbol
WWTR1provided by HGNC
Official Full Name
WW domain containing transcription regulator 1provided by HGNC
Primary source
HGNC:HGNC:24042
See related
Ensembl:ENSG00000018408 MIM:607392
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Homo sapiens
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as
TAZ
Annotation information
Note: TAZ (GeneID 6901) and WWTR1 (GeneID 25937) loci share the TAZ symbol/alias in common. TAZ is a widely used alternative name for the transcriptional coactivator with PDZ-binding motif (WWTR1) conflicting with the official symbol for tafazzin (TAZ). [19 Jun 2012]
Expression
Ubiquitous expression in gall bladder (RPKM 24.8), endometrium (RPKM 22.7) and 24 other tissues See more
Orthologs
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Genomic context

See WWTR1 in Genome Data Viewer
Location:
3q25.1
Exon count:
13
Annotation release Status Assembly Chr Location
109.20210514 current GRCh38.p13 (GCF_000001405.39) 3 NC_000003.12 (149517235..149724788, complement)
105.20201022 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (149235022..149442575, complement)

Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 13408 Neighboring gene eukaryotic translation elongation factor 1 alpha 2 pseudogene Neighboring gene transmembrane 4 L six family member 4 Neighboring gene RNA, U6 small nuclear 1098, pseudogene Neighboring gene WWTR1 antisense RNA 1 Neighboring gene COMM domain containing 2 Neighboring gene ankyrin repeat and ubiquitin domain containing 1 Neighboring gene RNA, U6 small nuclear 507, pseudogene

Genomic regions, transcripts, and products

Expression

  • Project title: HPA RNA-seq normal tissues
  • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
  • BioProject: PRJEB4337
  • Publication: PMID 24309898
  • Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Phenotypes

Associated conditions

Description Tests
Genome-wide association study of pre-eclampsia detects novel maternal single nucleotide polymorphisms and copy-number variants in subsets of the Hyperglycemia and Adverse Pregnancy Outcome (HAPO) study cohort.
GeneReviews: Not available

HIV-1 interactions

Replication interactions

Interaction Pubs
Knockdown of WW domain containing transcription regulator 1 (WWTR1; TAZ) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

Go to the HIV-1, Human Interaction Database

Pathways from PubChem

Interactions

Products Interactant Other Gene Complex Source Pubs Description

General gene information

Markers

Homology

Clone Names

  • FLJ27004, FLJ45718, DKFZp586I1419

Gene Ontology Provided by GOA

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
PubMed 
enables protein homodimerization activity IEA
Inferred from Electronic Annotation
more info
 
enables transcription coactivator activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
enables transcription coactivator activity IDA
Inferred from Direct Assay
more info
PubMed 
enables transcription coactivator activity NAS
Non-traceable Author Statement
more info
PubMed 
enables transcription corepressor activity IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
Process Evidence Code Pubs
involved_in SCF-dependent proteasomal ubiquitin-dependent protein catabolic process IEA
Inferred from Electronic Annotation
more info
 
involved_in cilium assembly IEA
Inferred from Electronic Annotation
more info
 
involved_in glomerulus development IEA
Inferred from Electronic Annotation
more info
 
involved_in heart process IEA
Inferred from Electronic Annotation
more info
 
involved_in hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in hippo signaling IDA
Inferred from Direct Assay
more info
PubMed 
involved_in kidney morphogenesis IEA
Inferred from Electronic Annotation
more info
 
involved_in mesenchymal cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in multicellular organism growth IEA
Inferred from Electronic Annotation
more info
 
involved_in negative regulation of canonical Wnt signaling pathway IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of fat cell differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in negative regulation of protein kinase activity IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of protein phosphorylation IMP
Inferred from Mutant Phenotype
more info
PubMed 
involved_in negative regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
 
involved_in osteoblast differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in positive regulation of cell population proliferation IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of epithelial to mesenchymal transition IDA
Inferred from Direct Assay
more info
PubMed 
involved_in positive regulation of osteoblast differentiation IGI
Inferred from Genetic Interaction
more info
PubMed 
involved_in positive regulation of protein localization to nucleus ISS
Inferred from Sequence or Structural Similarity
more info
 
involved_in positive regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
involved_in protein ubiquitination IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of SMAD protein signal transduction IDA
Inferred from Direct Assay
more info
PubMed 
involved_in regulation of metanephric nephron tubule epithelial cell differentiation IEA
Inferred from Electronic Annotation
more info
 
involved_in regulation of transcription, DNA-templated NAS
Non-traceable Author Statement
more info
PubMed 
involved_in stem cell division IDA
Inferred from Direct Assay
more info
PubMed 
involved_in tissue homeostasis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in cytoplasm IDA
Inferred from Direct Assay
more info
PubMed 
located_in cytosol IDA
Inferred from Direct Assay
more info
 
located_in cytosol TAS
Traceable Author Statement
more info
 
located_in nuclear body IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 
located_in nucleoplasm TAS
Traceable Author Statement
more info
 
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
PubMed 
located_in nucleus IDA
Inferred from Direct Assay
more info
PubMed 
located_in nucleus NAS
Non-traceable Author Statement
more info
PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
 
part_of transcription regulator complex IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
WW domain-containing transcription regulator protein 1
Names
transcriptional co-activator with PDZ-binding motif

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001168278.3NP_001161750.1  WW domain-containing transcription regulator protein 1

    See identical proteins and their annotated locations for NP_001161750.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 4. Variants 1 through 4 all encode the same protein.
    Source sequence(s)
    AC012014, AK022036, AK130514, AL833852, DA338432
    Consensus CDS
    CCDS3144.1
    UniProtKB/Swiss-Prot
    Q9GZV5
    Related
    ENSP00000419465.1, ENST00000465804.5
    Conserved Domains (1) summary
    smart00456
    Location:125156
    WW; Domain with 2 conserved Trp (W) residues
  2. NM_001168280.3NP_001161752.1  WW domain-containing transcription regulator protein 1

    See identical proteins and their annotated locations for NP_001161752.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 4. Variants 1 through 4 all encode the same protein.
    Source sequence(s)
    AC012014, AL833852, DA854089
    Consensus CDS
    CCDS3144.1
    UniProtKB/Swiss-Prot
    Q9GZV5
    Related
    ENSP00000419234.1, ENST00000467467.5
    Conserved Domains (1) summary
    smart00456
    Location:125156
    WW; Domain with 2 conserved Trp (W) residues
  3. NM_001348362.2NP_001335291.1  WW domain-containing transcription regulator protein 1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) represents the longest transcript. Variants 1 through 4 all encode the same protein.
    Source sequence(s)
    AC012014, AC069216, AC108672, BQ003163
    Consensus CDS
    CCDS3144.1
    UniProtKB/Swiss-Prot
    Q9GZV5
    Conserved Domains (1) summary
    smart00456
    Location:125156
    WW; Domain with 2 conserved Trp (W) residues
  4. NM_015472.6NP_056287.1  WW domain-containing transcription regulator protein 1

    See identical proteins and their annotated locations for NP_056287.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant 12) differs in the 5' UTR compared to variant 4. Variants 1 through 4 all encode the same protein.
    Source sequence(s)
    AC012014, AK130514, AL833852, BC014052, DA760311
    Consensus CDS
    CCDS3144.1
    UniProtKB/Swiss-Prot
    Q9GZV5
    Related
    ENSP00000353847.3, ENST00000360632.8
    Conserved Domains (1) summary
    smart00456
    Location:125156
    WW; Domain with 2 conserved Trp (W) residues

RefSeqs of Annotated Genomes: Homo sapiens Updated Annotation Release 109.20210514

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p13 Primary Assembly

Genomic

  1. NC_000003.12 Reference GRCh38.p13 Primary Assembly

    Range
    149517235..149724788 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_017006122.1XP_016861611.1  WW domain-containing transcription regulator protein 1 isoform X1

    UniProtKB/Swiss-Prot
    Q9GZV5
    Conserved Domains (1) summary
    smart00456
    Location:125156
    WW; Domain with 2 conserved Trp (W) residues
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